If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products

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dc.contributor.authorCastaneda-Loaiza, Viana
dc.contributor.authorPlacines, Chloe
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorPereira, Catarina
dc.contributor.authorZengin, Gökhan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorJeko, Jozsef
dc.date.accessioned2020-03-26T20:20:18Z
dc.date.available2020-03-26T20:20:18Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe halophyte species Carpobrotus edulis (L.) N.E. Br, also known as Hottentot-fig, is one of the 20 most aggressive invasive species of coastal areas worldwide. It is native to South Africa, where it is used in traditional medicine for the treatment of several diseases, including tuberculosis and acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV). Aiming at a sustainable use of its biomass as a value-added product, this work reports for the first time the in vitro antioxidant, anti-microbial, enzymatic inhibitory properties and toxicity of peel and flesh extracts of Hottentot-fig mature fruits. The extracts' chemical composition was also determined by spectrophotometric methods (total contents of phenolics: TPC; flavonoids: TFC and tannins: TTC), and by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS). The peels' extracts had generally the highest TPC, TFC and TTC, especially the ethanol ones (TPC: 272.82 mg gallic acid equivalents (GAE)/g dry weight (DW), TFC: 1.58 mg quercetin equivalents (QE)/g DW and TTC: 20.3 mg catechin equivalents (CE)/g DW). The peels' extracts also had the highest diversity of compounds, mostly phenolic acids, flavonoids, and coumarins, as identified by HPLC-ESI-MS/MS. Some molecules were specific to a particular fruit part, for example, coumaric acid and uvaol in the peel, and vanillin and kaempferol-O-(rhamnosyl)hexosylhexoside in the flesh. Some compounds are here described for the first time in Hottentot-fig, such as azelaic acid and emodin. The peel's extracts had the highest anti radical activity, especially the ethanol and acetone towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) (half maximal inhibitory concentration (IC50) values of 0.59 and 0.88 mg/mL, respectively), and the acetone extract against 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) (IC50 = 0.56 mg/mL). Samples had nil capacity to chelate iron, a low copper chelation potential, but a significant capacity to reduce iron, especially the ethanol (IC50 = 0.09 mg/mL) and the acetone extracts of peels (IC50 = 0.10 mg/mL) and flesh (IC50 = 0.11 mg/mL) and also the water peel's extracts (IC50 = 0.18 mg/mL). Samples had nil to low activity towards the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), alpha-amylase and alpha-glucosidase, but displayed a strong inhibition of tyrosinase, especially the ethanol peel's extracts (29.55 mg kojic acid equivalents (KAE)/g). Samples had nil to low in vitro toxicity towards human keratinocytes. All together our results suggests possible novel biotechnological applications of Hottentot-fig fruits as sources of innovative bioactive ingredients for the food, cosmetic, agriculture and/or pharmaceutical industries.en_US
dc.description.sponsorshipFoundation for Science and Technology (FCT)Portuguese Foundation for Science and Technology; Portuguese National Budget [CCMAR/Multi/04326/2019, UID/DTP/04138/2019]; GreenVet project [ALG-01-0145-FEDER-028876]; FCTPortuguese Foundation for Science and Technology [SFRH/BD/116604/2016, CEECIND/00425/2017]en_US
dc.description.sponsorshipWork supported by the Foundation for Science and Technology (FCT) and the Portuguese National Budget (CCMAR/Multi/04326/2019 project), UID/DTP/04138/2019 and GreenVet project (ALG-01-0145-FEDER-028876). Joao Rodrigues acknowledge FCT for the PhD grant SFRH/BD/116604/2016. Luisa Cust6dio was supported by the FCT Scientific Employment Stimulus (CEECIND/00425/2017).en_US
dc.identifier.citationCastaneda-Loaiza, V., Placines, C., Rodrigues, M. J., Pereira, C., Zengin, G., Uysal, A., Jeko, J., Cziaky, Z., Reis, C. P., Gaspar, M. M., Custodio, L. (2020). If You Cannot Beat Them, Join Them: Exploring the Fruits of the invasive Species Carpobrotus edulis (L.) N.E. Br as a Source of Bioactive Products. Industrial Crops & Products, 144, 1-11.
dc.identifier.doi10.1016/j.indcrop.2019.112005en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.112005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38555
dc.identifier.volume144en_US
dc.identifier.wosWOS:000510521700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEnzyme inhibitorsen_US
dc.subjectSalt tolerant plantsen_US
dc.subjectHottentot-figen_US
dc.subjectHyperpigmentationen_US
dc.subjectInvasive speciesen_US
dc.subjectOxidative stressen_US
dc.titleIf you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive productsen_US
dc.typeArticleen_US

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