Effects of caffeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model

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dc.contributor.authorAlp, Harun
dc.contributor.authorAytekin, Ismail
dc.contributor.authorEsen, Hasan
dc.contributor.authorBasarali, Kemal
dc.contributor.authorKul, Seval
dc.date.accessioned2020-03-26T18:14:20Z
dc.date.available2020-03-26T18:14:20Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the possible protective effects of caffeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic effects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in gamma-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative effects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic effects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic effects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.en_US
dc.identifier.citationAlp, H., Aytekin, I., Esen, H., Basaralı, K., Kul, S. (2011). Effects of Caffeic Acid Phenethyl Ester, Ellagic Acid, Sulforaphane and Curcumin on Diazinon Induced Damage to the Lungs, Liver and Kidneys in An Acute Toxicity Rat Model. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 17(6), 927-933.
dc.identifier.endpage933en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue6en_US
dc.identifier.startpage927en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26393
dc.identifier.volume17en_US
dc.identifier.wosWOS:000298308700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorEsen, Hasan
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiazinonen_US
dc.subjectEllagic aciden_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectSulforaphanen_US
dc.subjectCurcuminen_US
dc.titleEffects of caffeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat modelen_US
dc.typeArticleen_US

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