Volatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approach

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorMollica, Adriano
dc.contributor.authorStefanucci, Azzura
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorPoorneeka, Ramjuttun
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T20:11:39Z
dc.date.available2020-03-26T20:11:39Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe increasing therapeutic use of plant essential oil (EO) in aromatherapy has urged scientists to investigate into its biological potency. We report the phytochemical composition of the EO of Aegle marmelos (L.) Correa using GC-MS analysis, together with its pharmacological properties (antibacterial, antioxidant, and enzyme inhibitory properties). Molecular docking of the major identified compounds against tyrosinase and a-glucosidase was also performed. The EO displayed the highest total antioxidant potential in the phosphomolybdenum assay (24.70 mmol TE/g sample), but showed mild scavenging (DPPH = 0.03 mmol TE/g sample), and reducing effect (CUPRAC = 0.54 mmol TE/g sample, FRAP = 0.21 mmol TE/g sample). Moreover, the EO of A. marmelos showed the greatest inhibitory property against tyrosinase 53.68 (mg KAE/g sample) and good inhibitory effect on alpha-glucosidase (39.08 mmol ACAE/g sample) compared with alpha-amylase (0.19 mmol ACAE/g sample). In addition, the EO exhibited moderate AChE inhibition (2.75 mg GALAE/g sample) and BChE inhibition (4.93 mg GALAE/g sample). Disc diffusion assay revealed that S. aureus (Zone of inhibition (ZOI) = 21.4 mm) was most susceptible to the EO followed by C. diphtheriae (ZOI = 17.2 mm) while the lowest MIC value was observed against B. cereus and C. diphtheriae (MIC = 125 mu g/ml). The EO of A. marmelos was abundant in limonene (74.9%) followed by beta-phellandrene (4.4%), p-cyrnene (4.2%), and beta-caryophyllene (2.0%). Humulene and cryptone exhibited higher docking score after docking to tyrosinase while the best docking scores observed against alpha-glucosidase was found for humulene and carveol. The EO of A. marmelos showed promising inhibitory activities against vital enzymes related to diabetes, neurological, and skin disorders, and mild antioxidant ability, thus highlighting the quenching abilities of surplus reactive oxygen species related to these disorders. It is predicted that the results obtained will stimulate further research to probe into the therapeutic properties of A. marmelos.en_US
dc.identifier.doi10.1016/j.indcrop.2018.09.054en_US
dc.identifier.endpage21en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2018.09.054
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37127
dc.identifier.volume126en_US
dc.identifier.wosWOS:000452346400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAegle marmelosen_US
dc.subjectBaelen_US
dc.subjectAntibacterial, antidiabeticen_US
dc.subjectAntioxidantsen_US
dc.subjectCholinesteraseen_US
dc.subjectGC-MSen_US
dc.titleVolatile components, pharmacological profile, and computational studies of essential oil from Aegle marmelos (Bael) leaves: A functional approachen_US
dc.typeArticleen_US

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