Does Prenatal Exposure to Diclofenac Sodium Affect the Total Number of Cerebellar Granule Cells in Male Juvenile and Adult Rats?

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dc.contributor.authorEkici, Fatih
dc.contributor.authorKeskin, İlknur
dc.contributor.authorAslan, Hüseyin
dc.contributor.authorErişgin, Züleyha
dc.contributor.authorAltunkaynak, Berrin Zühal
dc.contributor.authorGökçimen, Alpaslan
dc.contributor.authorOdacı, Ersan
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2020-03-26T18:32:42Z
dc.date.available2020-03-26T18:32:42Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA developing embryo is exposed to side effects of diclofenac sodium (DS), a commonly used non-steroidal anti-infl ammatory drug, since women may incidentally become pregnant while receiving DS therapy. Several adverse effects of DS have been clearly established. However, the effects of prenatal exposure to DS on the developing cerebellum especially are unclear for granular cells. In this study, we investigated the total number of granule cells in the cerebellum in control and DS-treated groups of male rats using the optical fractionator technique. DS (Voltaren, 75 mg/3 ml) in a dose of 1 mg/kg daily was intraperitoneally injected in the drug-treated group of pregnant rats beginning from the 5th day after mating during pregnancy for 15 days. Serum physiological at 1 ml/kg dose was injected in the control group of pregnant rats during the same period and the same way. Male offspring were obtained after delivery, and each group was divided two subgroups that were 4-weeks-old (4W-old) and 20-weeks-old (20W-old). Our results showed that there was no signifi cant difference not only between the 4W-old DS-treated rats and the 4W-old control group but also between 20W-old DS-treated rats and the 20W-old control group. These results suggest that the development of the granule cells in the male cerebellum may not be affected during either in the early or late life of an animal following administration of DS during the prenatal period. © 2012 OMU All rights reserved.en_US
dc.identifier.citationEkici, F., Keskin, İ., Aslan, H., Erişgin, Z., Altunkaynak, B. Z., Gökçimen, A., Odacı, E., Kaplan, S., (2012). Does Prenatal Exposure to Diclofenac Sodium Affect the Total Number of Cerebellar Granule Cells in Male Juvenile and Adult Rats?. Journal of Experimental and Clinical Medicine (Turkey), 29(1), 52-57.
dc.identifier.doi10.5835/jecm.omu.29.01.013en_US
dc.identifier.endpage57en_US
dc.identifier.issn1300-2996en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://dx.doi.org/10.5835/jecm.omu.29.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28756
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKeskin, İlknur
dc.language.isoenen_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCerebellumen_US
dc.subjectDiclofenac sodiumen_US
dc.subjectGranule Cellen_US
dc.subjectMaleen_US
dc.subjectOptical Fractionatoren_US
dc.subjectRaten_US
dc.titleDoes Prenatal Exposure to Diclofenac Sodium Affect the Total Number of Cerebellar Granule Cells in Male Juvenile and Adult Rats?en_US
dc.typeArticleen_US

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