Screening of in vitro antioxidant and enzyme inhibitory activities of different extracts from two uninvestigated wild plants: Centranthus longiflorus subsp longiflorus and Cerinthe minor subsp auriculata

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorNithiyanantham, Srinivasan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCeylan, Ramazan
dc.contributor.authorUysal, Şengül
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorSelvi, Palanisamy Kalai
dc.date.accessioned2020-03-26T19:26:13Z
dc.date.available2020-03-26T19:26:13Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: The importance of plants products in traditional medicine has been recognized for some time. Two plants of Turkish origin, Centranthus longiflorus subsp. longiflorus and Cerinthe minor subsp. auriculata used as traditional Turkish medicine have remained uninvestigated for Alzheimer diseases and diabetes mellitus for their in vitro biological activity despite their use for sleep disorders. The antioxidant and enzyme inhibitory properties of these plants have not been reported. The aim of this study was to determine the total phenolics, flavonoids, and antioxidant as well as their enzyme inhibitory activity (in aqueous and solvent extracts). Methods: Antioxidant assays used standard methods to assess phosphomolybdenum, free radical scavenging activity, reducing power, and metal chelating activity on ferrous ions. Additionally, the extracts were tested also for enzyme inhibitory activity (Cholinesterase, Tyrosinase, a-amylase, and a-glucosidase). Results: Organic extracts showed the highest anti-cholinesterase (AChE, and BChE) activity, while aqueous extracts showed valuable Tyrosinase inhibitory activity. Total phenolics (expressed as gallic acid equivalents) in C. longiflorus subsp. longiflorus and C. minor subsp. auriculata were 46.2 and 25.4 mg in methanolic extracts, 27.5 and 26.2 mg in ethyl acetate extracts, and 37.9 and 46.6 mg in aqueous extracts, respectively. Similarly, total flavonoids (expressed as rutin equivalents) in C. longiflorus subsp. longiflorus and C. minor subsp. auriculata were 39.9 and 27.8 mg in methanolic extracts, 17.6 and 52.4 mg in ethyl acetate extracts, and 24.35 and 24.6 mg in aqueous extracts, respectively. Conclusion: The reported results may be valuable for preparing new food supplements and can represent a good model for the development of new drug formulations. (C) 2015 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.eujim.2015.12.004en_US
dc.identifier.endpage292en_US
dc.identifier.issn1876-3820en_US
dc.identifier.issn1876-3839en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage286en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.eujim.2015.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33971
dc.identifier.volume8en_US
dc.identifier.wosWOS:000381735900023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofEUROPEAN JOURNAL OF INTEGRATIVE MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectDiabetes mellitusen_US
dc.subjectPhenolicsen_US
dc.subjectTurkeyen_US
dc.subjectTraditional herbal medicineen_US
dc.titleScreening of in vitro antioxidant and enzyme inhibitory activities of different extracts from two uninvestigated wild plants: Centranthus longiflorus subsp longiflorus and Cerinthe minor subsp auriculataen_US
dc.typeArticleen_US

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