Protective effect of aprotinin on ischemia-reperfusion injury in rat ovary

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dc.contributor.authorSahin, Figen Kir
dc.contributor.authorCosar, Emine
dc.contributor.authorKoken, Gulengul
dc.contributor.authorToy, Hatice
dc.contributor.authorBasarali, Kemal
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2020-03-26T17:27:32Z
dc.date.available2020-03-26T17:27:32Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: We investigated the effects of aprotinin on reperfusion injury in a controlled experimental rat torsion-detorsion model. Methods: Thirty-two female Sprague-Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. In group III, torsion-detorsion was performed, plus 3 mL/kg saline was injected i.v. 30 min before detorsion. In group IV, torsion-detorsion was performed, plus aprotinin (30 000 KIU/kg) was injected 30 min before detorsion. Rats in the torsion group were killed after 360 degrees clockwise adnexial torsion for 3 h, and the ovaries were harvested. After 3 h of adnexial detorsion, the rats in the saline and aprotinin groups were killed and the adnexa were surgically removed. Results: Ovarian tissue damage scores were significantly different among groups. Ovarian tissue and serum malondialdehyde levels in group III were significantly higher than those of groups I and IV (P < 0.05). The serum levels of superoxide dismutase in group III were significantly lower than those of groups I and IV (P = 0.01). Tissue and serum xanthine oxidase, nitric oxide, and tissue superoxide dismutase levels were comparable among groups (P > 0.05). Conclusions: Aprotinin attenuates ischemia-reperfusion injury in a rat adnexial torsion-detorsion model.en_US
dc.identifier.doi10.1111/j.1447-0756.2008.00846.xen_US
dc.identifier.endpage800en_US
dc.identifier.issn1341-8076en_US
dc.identifier.issn1447-0756en_US
dc.identifier.issue5en_US
dc.identifier.pmid18834336en_US
dc.identifier.startpage794en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1447-0756.2008.00846.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22588
dc.identifier.volume34en_US
dc.identifier.wosWOS:000259270800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectaprotininen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectovaryen_US
dc.subjecttorsionen_US
dc.titleProtective effect of aprotinin on ischemia-reperfusion injury in rat ovaryen_US
dc.typeArticleen_US

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