Enhancing Effect of Calix[4]arene Amide Derivatives on Lipase Performance in Enantioselective Hydrolysis of Racemic Arylpropionic Acid Methyl Esters

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dc.contributor.authorUyanık, Arzu
dc.contributor.authorŞen, Nejdet
dc.contributor.authorYılmaz, Mustafa
dc.date.accessioned2020-03-26T19:23:58Z
dc.date.available2020-03-26T19:23:58Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCalix[4]arene amide derivatives were employed as new additives within the sol-gel encapsulation of lipase from Candida rugosa (CRL) to improve its catalytic properties. Evaluation of catalytic activity of the encapsulated lipases was acheived by enantioselective hydrolysis of both racemates, Naproxen methyl ester and 2-phenoxypropionic acid methyl ester, in aqueous buffer solution/isooctane reaction system. Results show that enantioselectivity was improved by using calix[4]arene amide derivatives-based encapsulated lipases. The reaction of naproxen methyl ester resulted in 47.6% conversion (x) in 24h with 88.9% enantiomeric excess of substrate (ee(s)), analogous to an enantioselectivity (E) value of 297 (E = 137 for the encapsulated free enzyme). The conversion of 2-phenoxypropionic acid methyl ester, obtained was 48.4% with E value of 327, enantiomeric excess of substrate (ee(s)) of 92% for the reaction time of 1h (E = 211 for the encapsulated free enzyme).en_US
dc.description.sponsorshipScientific Research Projects Foundation of Selcuk University (SUBAP)Selcuk University [2008-08101022]en_US
dc.description.sponsorshipWe thank the Scientific Research Projects Foundation of Selcuk University (SUBAP-Grant Number 2008-08101022) for financial support of this work produced from a part of A.U.'s Ph.D. Thesis.en_US
dc.identifier.doi10.1080/10406638.2015.1037005en_US
dc.identifier.endpage627en_US
dc.identifier.issn1040-6638en_US
dc.identifier.issn1563-5333en_US
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage613en_US
dc.identifier.urihttps://dx.doi.org/10.1080/10406638.2015.1037005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33546
dc.identifier.volume36en_US
dc.identifier.wosWOS:000387296000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofPOLYCYCLIC AROMATIC COMPOUNDSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subject2-Phenoxypropionic aciden_US
dc.subjectcalix[4]areneen_US
dc.subjectenantioselectivityen_US
dc.subjectlipaseen_US
dc.subjectnaproxenen_US
dc.subjectsol-gel encapsulationen_US
dc.titleEnhancing Effect of Calix[4]arene Amide Derivatives on Lipase Performance in Enantioselective Hydrolysis of Racemic Arylpropionic Acid Methyl Estersen_US
dc.typeArticleen_US

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