Correlation of Serum Leptin Level and Waist-to-hip Ratio (WHR) With Overall Survival of Patients With Metastatic Breast Cancer (MBC) Treated With Aromatase Inhibitors (AIs).

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dc.contributor.authorArtac, Mehmet
dc.contributor.authorBozcuk, Hakan
dc.contributor.authorKıyıcı, Aysel
dc.contributor.authorEren, Orhan Önder
dc.contributor.authorBoruban, Melih Cem
dc.contributor.authorÖzdoğan, Mustafa
dc.date.accessioned2020-03-26T17:47:40Z
dc.date.available2020-03-26T17:47:40Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction Our objective was to determine whether serum leptin levels and obesity-related factors could affect outcome for metastatic breast cancer (MBC) patients treated with aromatase inhibitors (AIs). Methods Sixty MBC patients treated with first line hormonal therapy were enrolled in this study. Results Median age was 51 years (range 28–75). Median leptin level was 19400 pg/ml (1970–91900) and estradiol level 29.6 pg/ml (4.0–181.9). Factors associated with overall survival in univariate analysis were age and waist-to-hip ratio (WHR), whereas only WHR retained significance in the multivariate analysis. However, no factor was associated with progression-free survival. However, WHR was found to be a significant prognostic marker only if the leptin level was C19400 pg/ml (HR = 0.38; 95% CI: 0.16–0.91). Conclusions This study suggests that serum leptin levels and WHR together may serve as potential prognostic markers in MBC patients treated with AIs.en_US
dc.identifier.citationArtac, M., Bozcuk, H., Kıyıcı, A., Eren, O. O., Boruban, M. C., Özdoğan, M., (2013). Correlation of Serum Leptin Level and Waist-to-hip Ratio (WHR) With Overall Survival of Patients With Metastatic Breast Cancer (MBC) Treated With Aromatase Inhibitors (AIs). Journal of Clinical Oncology, (20), 174-180. Doi: 10.1007/s12282-011-0322-1
dc.identifier.doi10.1200/jco.2010.28.15_suppl.1106en_US
dc.identifier.endpage180
dc.identifier.issn0732-183Xen_US
dc.identifier.issn1527-7755en_US
dc.identifier.startpage174
dc.identifier.urihttps://dx.doi.org/10.1007/s12282-011-0322-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24742
dc.identifier.volume20en_US
dc.identifier.wosWOS:000208852002621en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorArtac, Mehmet
dc.institutionauthorKıyıcı, Aysel
dc.institutionauthorEren, Orhan Önder
dc.institutionauthorBoruban, Melih Cem
dc.language.isoenen_US
dc.publisherAmer Soc Clinical Oncologyen_US
dc.relation.ispartofJournal of Clinical Oncologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMetastatic breast cancer
dc.subjectLeptin
dc.subjectWaist-to-hip ratio
dc.subjectWeight
dc.subjectAromatase inhibitors
dc.subjectHormonal therapy
dc.titleCorrelation of Serum Leptin Level and Waist-to-hip Ratio (WHR) With Overall Survival of Patients With Metastatic Breast Cancer (MBC) Treated With Aromatase Inhibitors (AIs).en_US
dc.typeConference Objecten_US

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