Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorPaksoy, Mehmet Yavuz
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorGlamocilja, Jasmina
dc.contributor.authorSokovic, Marina
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorCustodio, Luisa
dc.date.accessioned2020-03-26T20:19:09Z
dc.date.available2020-03-26T20:19:09Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractSeveral species of the Apiaceae family have been employed in traditional cultures for their curative virtues. The present study focused on five Apiaceae species, (Falcaria vulgaris (FV), Smyrniopsis aucher( (SA), Smyrniopsis mtutzurdagensis (SM), Smyrnium cordifolium (SC), and Actinolema macrolema (AM)). The antioxidant, enzyme inhibitory (alpha-amylase, alpha-glucosidase, acetyl- and butyrylcholinesterase, lipase, and tyrosinase), antimicrobial, phytochemical, and cytotoxicity profiles of the methanol extracts of the selected Apiaceae species were determined. SC extract (35.68 mg gallic acid equivalent/g extract) possessed the highest phenolic content while the AM extract (56.79 mg rutin equivalent/g extract) had the highest flavonoid content. HPLC-ESI-MS (High performance liquid chromatography-electrospray tandem mass spectrometry) analyses showed presence of ferulic acid in all the five species. SC extract exhibited high radical scavenging (59.28 and 94.31 mg Trolox equivalent [TE]/g extract, DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid), respectively) and reducing activity (161.44 and 113.62 mg TE/g extract, for CUPRAC (cupric reducing antioxidant capacity) and FRAP (ferric reducing antioxidant power), respectively). SM extract exhibited the highest cholinesterase's inhibitory action (3.82 and 4.76 mg galantamine equivalent/g extract, for acetyland butyrylcholinesterase, respectively). The extracts showed higher inhibition against alpha-glucosidase (7.32-11.99 mmol acarbose equivalent [ACAE]/g extract) compared to alpha-amylase (0.51-0.55 mmol ACAE/g extract). SC extract was the most active (137.54 mg kojic acid equivalent/g extract) tyrosinase inhibitor and FV extract (113.75 mg Orlistat equivalent/g) the best lipase inhibitor. SM extract showed potent antibacterial effect against B. cereus (MIC (minimum inhibitory concentration) 0.180 mg/mL), P. mirabilis (MIC 0.180 mg/mL), M. flavus (MIC 0.560 mg/mL), P. aeruginosa (MIC 0.275 mg/mL), and S. typhimurium (MIC 1.500 mg/mL). FV extract (MIC 0.140 mg/mL) suppressed A. fumigates growth. Cytotoxicity was assessed on murine macrophage (RAW 264.7), human embryonic kidney (HEK 293), and human hepatocellular carcinoma (HepG2) cell lines. FV (60.3%) and SM (57.4%) showed the highest reduction on RAW 264.7 cellular viability, whereas SM (74.1%) showed toxicity against HepG2. This study supports that the Apiaceae species could be considered as promising candidates for the development of novel pharmacophores for the management of several human ailments.en_US
dc.identifier.citationZengin, G., Mahomoodally, M. F., Paksoy, M. Y., Picot-Allain, C., Glamocilja, J., Sokovic, M., Diuzheva, A., Jeko, J., Cziaky, Z., Rodrigues, M. J., Sinan, K. I., Custodio, L. (2019). Phytochemical Characterization and Bioactivities of Five Apiaceae Species: Natural Sources for Novel Ingredients. Industrial Crops and Products, 135, 107-121.
dc.identifier.doi10.1016/j.indcrop.2019.04.033en_US
dc.identifier.endpage121en_US
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2019.04.033
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38107
dc.identifier.volume135en_US
dc.identifier.wosWOS:000471086000013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorSinan, Kouadio Ibrahime
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofINDUSTRIAL CROPS AND PRODUCTSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectApiaceaeen_US
dc.subjectLipaseen_US
dc.subjectAntibacterialen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectEnzymesen_US
dc.titlePhytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredientsen_US
dc.typeArticleen_US

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