Yazar "Avunduk, M. C." seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Effect of Pinealectomy and Melatonin Supplementation on Metallothionein, Zinc Transport Protein Levels in the Small Intestine Sections of the Rat(WILEY, 2017) Unal, O.; Baltaci, A. K.; Mogulkoc, R.; Avunduk, M. C.[Abstract not Available]Öğe Effect of Resveratrol Application on Lipid Peroxidation in Experimental Renal Ischemia-Reperfusion Injury in Rats(WILEY, 2017) Baltaci, A. K.; Gokbudak, H.; Mogulkoc, R.; Avunduk, M. C.; Menevse, E.[Abstract not Available]Öğe The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study(WILEY-BLACKWELL PUBLISHING, INC, 2009) Genc, E.; Avunduk, M. C.; Genc, B. Oguz; Sahin, A. Saide; Oz, M.Objective - To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods - Male Sprague-Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results - A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion - Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.Öğe The effects of prophylactic zinc and melatonin application on experimental spinal cord ischemia-reperfusion injury in rabbits: experimental study(NATURE PUBLISHING GROUP, 2007) Kalkan, E.; Çiçek, O.; Ünlü, Ali; Abuşoğlu, Sedat; Kalkan, S. S.; Avunduk, M. C.; Baysefer, A.Study design: Experimental study. Objectives: To determine the neuroprotective effects of zinc and melatonin on spinal cord ischemia-reperfusion (I/R) injuries of rabbits. Setting: The Experimental Research Centre of Selcuk University, Konya, Turkey. Methods: Twenty-four male rabbits underwent spinal cord ischemia by clamping the thoraco-abdominal aorta for 20 min. Twenty-minutes before the aortic clamping, animals received zinc, melatonin or a combination of both. Neurological examination of the animals was performed three times during reperfusion period. The animals were killed 24 h after reperfusion. Spinal cord samples were taken for biochemical and histopathological evaluation. Results: Pre-treated animals with zinc, melatonin or combination displayed better neurological outcomes than the I/R group (P < 0.05). Zinc, melatonin and combined treatment prevented spinal cord injury by reducing apoptosis rate (P < 0.05) and preserving intact ganglion cell numbers (P < 0.05). Zinc pre-treatment protected spinal cord by preventing malondialdehyde (MDA) formation (P = 0.002), increasing glutathione peroxidase (GPx) activity(P = 0.002) and decreasing xanthine oxidase enzyme activity (P = 0.026) at molecular level. Melatonin treatment also resulted with MDA formation (P = 0.002), increased GPx activity (P = 0.002) and decreased xanthine oxidase activity(P = 0.026). Conclusion: The results of the study showed that prophylactic zinc and melatonin use in spinal cord I/R not only suppressed lipid peroxidation by activating antioxidant systems but also had significant neuroprotective effects by specifically improving the neurological and histopathological situation.Öğe The effects of resveratrol administration on lipid oxidation in experimental renal ischemia-reperfusion injury in rats(TAYLOR & FRANCIS LTD, 2019) Baltaci, A. K.; Gokbudak, H.; Baltaci, S. B.; Mogulkoc, R.; Avunduk, M. C.We investigated how resveratrol affects lipid oxidation during experimental renal ischemia-reperfusion injury in rats. We used 48 adult male rats assigned to five groups: group 1, control; group 2, renal ischemia; group 3, renal ischemia + reperfusion; group 4, resveratrol + renal ischemia; group 5, resveratrol + renal ischemia + reperfusion. Plasma and renal tissue malondialdehyde (MDA), and erythrocyte and renal tissue glutathione (GSH) levels were measured and histologic changes in the renal tissue were examined. Ischemia-reperfusion affected the MDA-GSH balance adversely and caused histopathological changes in the renal tissue of the ischemia and ischemia + reperfusion groups. Resveratrol treatment normalized MDA and GSH levels as well as the histopathology that occurred in the renal tissue of the ischemia and ischemia + reperfusion groups.Öğe A Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitis(1998) Avunduk, A. M.; Avunduk, M. C.; Dayanır, V.; Tekelioğlu, Y.; Dayıoğlu, Y. S.Background: Vernal keratoconjunctivitis (VKC) is a bilateral seasonal conjunctival inflammation. Exact pathogenesis of the disease is unknown, but some evidences suggest TH lymphocyte-mediated immune reactions. Objective: The aim of this study was to investigate the role of the T lymphocyte and its subsets in the pathogenesis of VKC. Methods: We obtained tear samples from patients with VKC and normal volunteers during active (spring) and quiescent (winter) periods. The patients' records were also obtained for assessment of symptom scores. The percentages of CD4/29+, CD4/45RA+, CD4+, and CD8+ in tear samples were established by using flow cytometry, and the results of all three groups were compared with each other by using the Wilcoxon matched-pair signed-rank test and the Mann-Whitney U test. Results: The percentages of CD4/29+ and CD4+ cells in tears of patients with VKC increased significantly in the active period and decreased to normal levels in the quiescent stage. In contrast, the percentages of CD4/45RA+ and CD8+ cells in tears of patients with VKC did not show any significant change between spring and winter. The patients' symptoms were significantly lower in the quiescent period (winter) compared with the active stage (spring). Conclusion: We propose that increased numbers of CD4+ and CD4/29+ cells in tears may be exacerbating the disease during the spring season.Öğe Tissue reaction of various denture base resins on the rabbit palatal mucosa: An immunobistochemical study.(INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R, 2003) Avunduk, M. C.; Aykent, F.; Durmus, E.; Usumez, A.; Baltaci, A. K.[Abstract not Available]
