A Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitis
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Vernal keratoconjunctivitis (VKC) is a bilateral seasonal conjunctival inflammation. Exact pathogenesis of the disease is unknown, but some evidences suggest TH lymphocyte-mediated immune reactions. Objective: The aim of this study was to investigate the role of the T lymphocyte and its subsets in the pathogenesis of VKC. Methods: We obtained tear samples from patients with VKC and normal volunteers during active (spring) and quiescent (winter) periods. The patients' records were also obtained for assessment of symptom scores. The percentages of CD4/29+, CD4/45RA+, CD4+, and CD8+ in tear samples were established by using flow cytometry, and the results of all three groups were compared with each other by using the Wilcoxon matched-pair signed-rank test and the Mann-Whitney U test. Results: The percentages of CD4/29+ and CD4+ cells in tears of patients with VKC increased significantly in the active period and decreased to normal levels in the quiescent stage. In contrast, the percentages of CD4/45RA+ and CD8+ cells in tears of patients with VKC did not show any significant change between spring and winter. The patients' symptoms were significantly lower in the quiescent period (winter) compared with the active stage (spring). Conclusion: We propose that increased numbers of CD4+ and CD4/29+ cells in tears may be exacerbating the disease during the spring season.
Açıklama
Anahtar Kelimeler
CD4+ Lymphocyte, CD4/ 29+ Lymphocyte, CD4/45RA+ Lymphocyte, Immunopathology, Vernal Keratoconjunctivitis
Kaynak
Journal of Allergy and Clinical Immunology
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
101
Sayı
6
Künye
Avunduk, A. M., Avunduk, M. C., Dayanır, V., Tekelioğlu, Y., Dayıoğlu, Y. S., (1998). A Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitis. Journal of Allergy and Clinical Immunology, 101(6), 821-824.
