A Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitis

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dc.contributor.authorAvunduk, A. M.
dc.contributor.authorAvunduk, M. C.
dc.contributor.authorDayanır, V.
dc.contributor.authorTekelioğlu, Y.
dc.contributor.authorDayıoğlu, Y. S.
dc.date.accessioned2020-03-26T16:26:30Z
dc.date.available2020-03-26T16:26:30Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Vernal keratoconjunctivitis (VKC) is a bilateral seasonal conjunctival inflammation. Exact pathogenesis of the disease is unknown, but some evidences suggest TH lymphocyte-mediated immune reactions. Objective: The aim of this study was to investigate the role of the T lymphocyte and its subsets in the pathogenesis of VKC. Methods: We obtained tear samples from patients with VKC and normal volunteers during active (spring) and quiescent (winter) periods. The patients' records were also obtained for assessment of symptom scores. The percentages of CD4/29+, CD4/45RA+, CD4+, and CD8+ in tear samples were established by using flow cytometry, and the results of all three groups were compared with each other by using the Wilcoxon matched-pair signed-rank test and the Mann-Whitney U test. Results: The percentages of CD4/29+ and CD4+ cells in tears of patients with VKC increased significantly in the active period and decreased to normal levels in the quiescent stage. In contrast, the percentages of CD4/45RA+ and CD8+ cells in tears of patients with VKC did not show any significant change between spring and winter. The patients' symptoms were significantly lower in the quiescent period (winter) compared with the active stage (spring). Conclusion: We propose that increased numbers of CD4+ and CD4/29+ cells in tears may be exacerbating the disease during the spring season.en_US
dc.identifier.citationAvunduk, A. M., Avunduk, M. C., Dayanır, V., Tekelioğlu, Y., Dayıoğlu, Y. S., (1998). A Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitis. Journal of Allergy and Clinical Immunology, 101(6), 821-824.
dc.identifier.endpage824en_US
dc.identifier.issn0091-6749en_US
dc.identifier.issue6en_US
dc.identifier.pmid9648710en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage821en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16830
dc.identifier.volume101en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, M. C.
dc.language.isoenen_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCD4+ Lymphocyteen_US
dc.subjectCD4/ 29+ Lymphocyteen_US
dc.subjectCD4/45RA+ Lymphocyteen_US
dc.subjectImmunopathologyen_US
dc.subjectVernal Keratoconjunctivitisen_US
dc.titleA Flow Cytometric Study About the Immunopathology of Vernal Keratoconjunctivitisen_US
dc.typeArticleen_US

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