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Öğe Anaplasma Marginale Infections in Dairy Cattle: Clinical Disease With High Seroprevalence(Natl Veterinary Research Inst, 2006) Birdane, Fatih Mehmet; Sevinç, FerdaThe fatal Anaplosma marginale infections were reported in a dairy cattle herd located in the Interior Aegean Region of Turkey fifteen Holstein dairy cows which had the symptoms of fever, weakness, depression, lack of appetite and decreasing of milk yields had died during January and March 2004. Inclusion bodies, characteristic of A. marginale, in erythrocytes of the sick cows were found. File presence of this agent was subsequently verified by serology. Then, the blood samples were collected from randomly selected 645 cattle which were grouped according to their age as follows: < 9 months, 9-12 months, and 1-2, 2-3, 3-4, > 4 years. The presence of A. marginale was determined by light microscopic examination of Giemsa-staincd blood smears. Serum samples were tested for the presence of antibodies against A. marginale by cELISA. Of 645 animals, 357 (55.35%) and 220 (34.11%)) were positive serologically and microscopically, respectively. The rates of the infection were different in the age groups. The specific antibodies against A. marginale were detected in 24.0%, 0.0%, 4.0%, 34.69%, 58.21%, and 82.07% of the cattle in the above age groups, respectively. The present report describes the first case of severe A marginale infection in a cattle herd.Öğe Blood and Colostrum/Milk Serum Gamma-Glutamyltransferase Activity as a Predictor of Passive Transfer Status in Lambs(Blackwell Verlag Gmbh, 2003) Maden, Mehmet; Altunok, Vahdettin; Birdane, Fatih Mehmet; Aslan, V.; Nizamlıoğlu, MustafaThe importance of blood and colostrum/milk serum gamma-glutamyl transferase (gamma-GT) enzyme activity was evaluated to assess passive transfer status in healthy lambs. Thirty Akkaraman sheep (3-6 years old) were used which had normal pregnancy period and the same conditions, and the age of the lambs ranged between 0 and 15 days. Blood and colostrum/milk samples were collected from sheep and lambs after birth, before suckling (0) and after on 1st, 3rd, 7th and 15th days. Serum immunoglobulin G (IgG) concentration was determined by the use of Single Radial Immunodiffusion method. Serum gamma-GT activity was measured, using a commercially available kit in blood and colostrum/milk samples. Correlations were carried out between immunoglobulin and gamma-GT levels. Regression models (simple and multiple) were calculated with significant data. Linear correlation was determined between colostrum/milk gamma-GT activity and IgG concentrations and between serum gamma-GT activity and IgG concentrations in lambs on the 0 day. (r: 0.607, P: 0.001), 1st (r: 0.768, P: 0.001) and the 3rd (r: 0.603, P: 0.001) days and on the 1st (r: 0.637, P: 0.001) and 3rd (r: 0.478, P: 0.012) days in the experiment, respectively. Multivariate regression models were developed to estimate sample IgG concentration. Serum and colostrum/milk IgG concentration could be predicted using the formula: lamb serum IgG = 825 + 0.688 (lamb gamma-GT) + 52 (days); colostrum/milk IgG = 832 + 0.505 (colostrum/milk gamma-GT) - 167 (days). The regression models were moderately accurate in predicting serum IgG concentration (R-2 = 0.51) and colostrum/milk IgG concentration (R-2 = 0.55). Test sensitivity and positive predictive values for serum gamma -GT enzyme activity were found to be 96 and 100% and for colostrum/milk gamma-GT enzyme activity were found to be 100 and 68% to prediction IgG concentration. Serum and colostrum/milk gamma-GT activity can be used to assess passive transfer status of lambs. Along with this, regression models used to calculate serum and colostrum/milk gamma-GT activities found to be useful to estimate sample IgG concentration. The use of serum and colostrum/milk gamma-GT enzyme activity was found useful especially after birth on the 0, 1st and 3rd days.Öğe Buzağılarda Solunum Yolu Enfeksiyonlarının Tanısında Bronkoalveolar Lavaj Sıvısı Muayenelerinin Önem(Selçuk Üniversitesi, 2002) Birdane, Fatih Mehmet; Aslan, VeysiYapılan çalışmada buzağılanın solunum sistemi enfeksiyonlarının tanısında BAL sıvısındaki biyokimyasal ve sitolojik değişikliklerin belirlenmesinin yaranı araştırıldı.Bu amaçla, 18 akut, 17 kronik solunum sistemi enfeksiyonlu ve 11 sağlıklı buzağı kullanıldı. Tüm buzağıların klinik muayenesi, tam kan analizi ve BAL sivisi analizleri yapıldı. Bron- koalveolar lavaj sıvısı sitolojik, biyokimyasal ve bakteriyolojik yönden incelendi. Bronkoalveolar lavaj sıvisi laktat de- hidrogenaz (LDH), alkalen fosfataz (ALP), aktiviteleri ve total protein konsantrasyonları, akut ve kronik solunum enfeksiyonu bulunan buzağılarda, sağlıklı gruba göre önemli ölçüde (p<0.01) yüksek olarak belirlendi. Sağlıklı grup ile karşılaştırıldığında akut ve kronik solunum enfeksiyonu bulunan buzağılanın BAL sıvısı nötrofil oranları önemli (p<0.01) ölçüde yüksek bulundu. Bronkoalveolar lavaj sıvisi makrofaj oranı akut ve kronik solunum sistemi enfeksiyonu bulunan buzağılarda normal buzağılara göre düşüktü. Kronik solunum sistemi enfeksiyonu bulunan buzağıların BAL sıvısı makrofaj oranlan akut enfeksiyonlu gruba göre daha yüksekti. Bu çalışmanın sonuçlanı BAL SIVISI analizlerinin pnömonik buzağıların spesifik tanısında hızlı, basit ve güvenli bir yöntem olduğuna karar verildi. Diagnostik amaçla BAL Svisi LDH, ALP aktiviteleri ve makrofaj, nötrofil yüzdelerinin belirlenmesi değerli bulunmuştur. Solunum sisteminin sitolojisi, daha kompleks diagnostik işlemler yapılana kadar hastaya uygulanacak işlemlerin seçilmesinde yönelik bilgi ve etiyopatolojik bir tanı sağlayabilir.Öğe Buzağılarda solunum yolu enfeksiyonlarının tanısında bronkoalveolar lavaj sıvısı muayenelerinin önemi(2002) Birdane, Fatih Mehmet; Aslan, VeysiYapılan çalışmada buzağıların solunum sistemi enfeksiyonlarının tanısında BAL sıvısındaki biyokimyasal ve si-tolojik değişikliklerin belirlenmesinin yararı araştırıldı.Bu amaçla, 18 akut, 17 kronik solunum sistemi enfeksiyonlu ve 11 sağlıklı buzağı kullanıldı. Tüm buzağıların klinik muayenesi, tam kan analizi ve BAL sıvısı analizleri yapıldı. Bron-koalveolar lavaj sıvısı sitolojik, biyokimyasal ve bakteriyolojik yönden incelendi. Bronkoalveolar lavaj sıvısı laktat dehidrogenaz (LDH), alkalen fosfataz (ALP), aktiviteleri ve total protein konsantrasyonları, akut ve kronik solunum enfeksiyonu bulunan buzağılarda, sağlıklı gruba göre önemli ölçüde (p0.01) yüksek olarak belirlendi. Sağlıklı grup ile karşılaştırıldığında akut ve kronik solunum enfeksiyonu bulunan buzağıların BAL sıvısı nötrofil oranları önemli (p0.01) ölçüde yüksek bulundu. Bronkoalveolar lavaj sıvısı makrofaj oranı akut ve kronik solunum sistemi enfeksiyonu bulunan buzağılarda normal buzağılara göre düşüktü. Kronik solunum sistemi enfeksiyonu bulunan buzağıların BAL sıvısı makrofaj oranları akut enfeksiyonlu gruba göre daha yüksekti. Bu çalışmanın sonuçları BAL sıvısı analizlerinin pnömonik buzağıların spesifik tanısında hızlı, basit ve güvenli bir yöntem olduğuna karar verildi. Diagnostik amaçla BAL sıvısı LDH, ALP aktiviteleri ve makrofaj, nötrofil yüzdelerinin belirlenmesi değerli bulunmuştur. Solunum sis-teminin sitolojisi; daha kompleks diagnostik işlemler yapılana kadar hastaya uygulanacak işlemlerin seçilmesinde yönelik bilgi ve etiyopatolojik bir tanı sağlayabilir.Öğe Clinical Efficacy of Florfenicol in the Treatment of Calf Respiratory Tract Infections(Royal Netherlands Veterinary Assoc, 2002) Aslan, V.; Maden, Mehmet; Erganis, Osman; Birdane, Fatih Mehmet; Çorlu, M.This paper reports on a study of the aetiology of calf pneumonia and the clinical efficacy of florfenicol, a new antibiotic in Turkey. Twenty-seven weaned and unweaned calves (13 males and 14 females) between I and 16 months of age brought to the clinics of Selcuk University, Faculty of Veterinary Science. Broncho-alveolar lavage (BAL) fluid samples were taken from the animals diagnosed to have upper respiratory tract infection associated with bronchitis (N=2), bronchitis (N=5), bronchopneumonia (N=4), pneumonia (N=3), pleuropneumonia (N=11), bronchopneumonia plus pulmonary oedema (N=2) based on the results of the clinical and laboratory examinations. Then microbiological isolation and antibiotic culturing were performed. The animals were treated with I ml/15 kg (20 mg/kg) florfenicol (Nuflor(R), DIF) twice within 48 hours via intramuscular injection. At the end of the treatment, 23 of the weaned and unweaned calves were completely healed, I calf had died and 3 calves showed no healing. The results of BAL samples and microbiological examinations of the 3 calves that did not respond to the treatment indicated that these cases were affected by mixed infections of yeasts, fungi, and bacteria. Widespread pleuropneumonia was observed. According to the results of the microbiological examination of the BAL samples, Mannheimia (Pasteurella) haemolytica had the highest isolation rate (25%) compared with the other isolated bacteria, namely, Klebsiella pneumonia (20%), Actinomyces pyogenes (15%), beta-hemolytic streptococci. (10%), Staphylococcus spp. (5%), and E. coli (5%). The study also revealed fungi [Penicillum spp. (5%) and Aspergillus spp. (5%)] and two calves (10%) had a yeast infection.. We conclude that florfenicol has a high bacteriological and clinical efficacy (100% and 96% respectively) in the treatment of calf respiratory tract diseases.Öğe Concentration of Insulin and Glucose in Dairy Cows With Abomasal Displacement(Indian Veterinary Journal, 2000) Ok, Mahmut; Şen, İsmail; Birdane, Fatih Mehmet; Sevinç, Mutlu; Aslan, Veysi; Alkan, Feyzanur[Abstract not Available]Öğe Concentrations of total serum immunoglobulin e, a, g and m in stray dogs with healthy and dermatological problems(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013) Maden, Mehmet; Birdane, Fatih Mehmet; Ucan, Uckun Sait; Altunok, VahdettinIn this study, clinical and laboratory findings along with serum IgE, IgA, IgM and IgG concentrations were determined in stray dogs (healthy and with dermatological problems). It was determined that skin lesions were localized in the rate of 69.8% (n=44) and generalized in the rate of 30.2% (n=19) of sick animals. Serum IgE concentration in stray dogs with dermatologic problems was significantly higher (P<0.001) than that of healthy dogs whereas serum IgM and G concentrations were significantly lower (P<0.05). It was evaluated that, serum total immunoglobulin concentrations could be useful in making contribution to differential diagnosis of skin diseases in stray dogs.Öğe Efficacy of Sodium Borate in the Prevention of Fatty Liver in Dairy Cows(Amer Coll Veterinary Internal Medicine, 2002) Başoğlu, Abdullah; Sevinç, Mutlu; Birdane, Fatih Mehmet; Boydak, MuratThe effects of sodium borate (100 mg/kg body weight, PO, 15 days) from a month before expected calving until a month after calving were evaluated in dairy cows susceptible to fatty liver. Cows received either sodium borate (n = 13) or no treatment (n = 10). All cows had mild fatty livers and increased plasma triglycerides and very low density lipoprotein (VLDL) concentrations at the beginning of the experiment. The control group of cows developed significant fatty liver after calving, and 2 of them had severe fatty liver associated with clinical and biochemical abnormalities. There were no clinicopathological signs related to sodium borate administration. Serum triglycerides and VLDL concentrations before calving decreased significantly at calving and after calving in controls, and they were within the normal range only after calving. There were significant alterations during the experiment in some hematological and chemical variables between groups, within period, but they were within the normal range. Unlike treated cows, serum triglycerides and VLDL concentrations correlated with liver fat content after calving in untreated cows. Our results document that sodium berate decreases the degree of fatty liver in dairy cows during early lactation.Öğe Farklı Yaş Gruplarındaki? Anadolu Mandalarında Bazı Serum Bi?yoki?myasal Parametrelerdeki? Deği?şi?mler(Selçuk Üniversitesi, 2005) Civelek, Turan; Birdane, Fatih Mehmet; Küçükkebabçı, MustafaÇalışmada farklı yaş gruplarındaki Anadolu mandalarının serumlarında bazı biyokimyasal parametrelerdeki değişimler araştırılmıştır. Klinik olarak sağlıklı, heriki toplam 93 Anadolu mandası üzerinde yürütülen çalışma sonuçları, BUN, TG, VLDL ve GLU konsantrasyonlarının yenidoğanlarda ve 6-24 ay yaş grubunda; CHOL, HDL ve CREA serum konsantrasyonlarının ise 6-24 ay ve 236 ay yaş gruplarında benzer seviyelerde olduğunu ortaya koymuştur. LDH ve TP serum konsantrasyonlarının ise her üç grup için farklilik arz ettiği belirlenmiştir.Öğe Investigation of Biochemical and Haematological Side-Effects of Cefquinome in Healthy Dogs(Royal Netherlands Veterinary Assoc, 2001) Maden, Mehmet; Traş, Bünyamin; Baş, Ahmet Levent; Elmas, Muammer; Yazar, Enver; Birdane, Fatih Mehmetin the present study, the effects of cefquinome, a 4(th) generation cephalosporin, on clinical, biochemical, haematological, and blood gas variables were investigated. Five healthy dogs were injected with cefquinome (1 mg/kg body weight, IM, daily) for 14 days. Negative effects of cefquinome on clinical, biochemical, and haematological variables were not observed, but it did change some blood gas variables.Öğe Oksi?tetrasi?kli?ni?n Köpeklerde Bi?yoki?myasal Toksi?k Etki?leri?ni?n Araştırılması(Selçuk Üniversitesi, 1999) Traş, Bünyamin; Elmas, Muammer; Maden, Mehmet; Baş, Ahmet Levent; Yazar, Enver; Birdane, Fatih MehmetIn the present study, biochemical toxic effects of oxytetracycline, widely using in veterinary medicine, on metabolisms of Ca, IP. Mg and vitamin D were investigated. Clinical and laboratory parameters were observed at recommended dose and time period. In this study, healthy 5 dogs (different age and sex) were used as materials. Oxytetracycline (Primamycine-Pfizer) was injected ( 20mg / k * g IM, one a day) to all dogs during 14 days. In 14th day of experiment, it was observed that statistically significant (p < 0.01) decrease at concentrations of ICa and adjusted Ca no significant increase (p > 0.05) at serum levels of PTH, IP and Mg, and no significant decrease (p > 0.05) at serum level of vitamin D. As a result, oxytetracycline may change metabolisms of Ca, Mq P and vitamin D, therefore it must be considered that metabolisms of Ca, Mg, P and vitamin D during long term oxytetracycline treatment.Öğe Role of Gastrin in the Aetiology of Abomasal Displacement in Dairy Cows(BRITISH VETERINARY ASSOC, 2002) Şen, I.; Ok, M.; Turgut, K.; Birdane, Fatih Mehmet; Güzelbektaş, H.It was considered that this incident posed no risk to the human food chain because the animals were already prohibited from sale for human consumption by the long withdrawal period of this anthlemintic. In addition, the worst-affected lambs had been culled for postmortem examination. However, a routine report was completed under the Suspected Adverse Reaction Surveillanice Scheme for the Veteriniary Medicines Directorate.Öğe Serum and colostrum/milk alkaline phosphatase activities in the determination of passive transfer status in healthy lambs(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2004) Maden, Mehmet; Birdane, Fatih Mehmet; Altunok, Vahdettin; Dere, S.The aim of this study was to evaluate the importance of serum and colostrum/milk alkaline phosphatase (ALP) enzyme activity in the determination of passive transfer status in healthy lambs. Thirty Akkaraman Sheep (3-6 years old) which had normal pregnancy period and their 0 to 15 days old lambs (n=30) were used. Blood and colostrum/dmilk samples were collected from sheep and lambs after birth, before suckling (0 Day) and at the 1(st), 3(rd), 7(th) and 15(th) day. Serum IgG concentration was determined by the use of Single Radial Immunodiffusion (SRID) method. Serum ALP activity was measured, using a colorimetric kit. Correlations were carried out between immunoglobulin concentrations and ALP activities. Regression models (simple and multiple) were calculated. In lambs, although positive correlations were obtained between ALP activities and 1, G concentrations in serum at Days 1, 3 and 7 (r = 0.689, p < 0.01, r = 0.464, p < 0.05 and r = 0.413, p < 0.05 respectively), the variations of the 2 parameters showed marked discrepancies during the experiment : the ALP activity was maximum at day 0 whereas IgG concentrations were very low and from day 7 to day 15, ALP activity rose tip when IgG concentrations continued to decrease. From day 0 to day 7, ALP activities decreased in colostrum/milk whereas IgG concentrations were stable. Positive correlations between these 2 variables were only found on days 1 and 3 (r 0.404, p < 0.05 and r = 0.580, p < 0.01 respectively). Consequently, ALP activities were not strictly correlated with IgG concentrations nor in colostrum/milk either in lamb serum, and multiple regression models were not really suitable to calculate IgG concentrations. ALP activity is not Suitable for accurately predicting lamb IgG status and eventual failure for immune passive transfer.Öğe Specific Enzyme Activities in Bronchoalveolar Lavage Fluid as an Aid to Diagnosis of Tracheobronchitis and Bronchopneumonia in Dogs(W B SAUNDERS CO LTD, 2001) Maden, Mehmet; Altunok, Vahdettin; Birdane, Fatih Mehmet; Aslan, V; Nizamlioglu, MLactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase and gamma-glutamyl transferase enzyme activities, and total protein (TP), calcium, inorganic phosphate. urea nitrogen (UN) and creatinine concentrations in bronchoalveolar lavage fluid were investigated for their relative importance in the diagnosis of respiratory diseases in dogs. Bronchoalveolar lavage (BAL) fluid was obtained from 26 dogs (20 with respiratory diseases and six controls) following anaesthesia with sodium pentothal. Enzyme activities and biochemical parameters were measured in BAL fluid. LDH and ALP levels were significantly increased in 12 dogs with bronchopneumonia, but not in eight dogs with tracheobronchitis. Insignificant and variable levels of TP and UN concentrations were found in both groups. It was concluded that LDH and ALP enzyme activities could be considered as pointers to pulmonary inflammation and/or damage while TP and UN measurements in BAL fluid may have a place in the identification of changes in respiratory and vascular permeability. (C) 2001 Harcourt Publishers Ltd.Öğe Study on Some Blood Biochemical Parameters in Premature Calves(Indian Veterinary Journal, 2000) Ok, Mahmut; Birdane, Fatih Mehmet; Sen, İsmail; Güzelbektaş, HasanDecreased gestational age, low birth weight, and the presence of short silky haircoat, general weakness or floppiness have been limited criteria of premature calves (Paradis, 1984; Koterba and Madigan, 1990). Fetuses discharged from day 42 until approximately 260 days are generally called abortions, and from day 260 until term as premature deliveries (Miller, 1986, Robert, 1986). The objective of this study was to determine alteration of some blood biochemical parameters in premature calves.Öğe Thyroxine and triiodothyronine levels in premature calves(2004) Irmak, Kemal; Şen, İsmail; Birdane, Fatih MehmetÇalışmada prematür buzağılarda serum total T_4 and total T_3 konsantrasyonlarım tespit etmek amaçlandı. Bu çalışmada, 20 adet prematür ve 10 adet yeni doğmuş sağlıklı buzağı materyal olarak kullanıldı. Prematür buzağılarda serum T_4 düzeyi yeni doğmuş sağlıklı buzağılara göre yüksek (10.40.6 \mu g/dl) (p0.001), T_3 düzeyi ise düşüktü (1.20.02 ng/ml) (p0.001). Prematür buzağılarda serum trigliserit, kolesterol ve glikoz konsantrasyonları yeni doğmuş sağlıklı buzağılara göre düşük (p0.001) olarak tespit edildi. Prematür buzağılarda, troid hormonlarının önemini ortaya koyan ilave çalışmaların yapılması gereklidir.
