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Bir aylık köpekte gastrik dilatasyon ve kronik gastritis
(2010) Maden, Mehmet; Öztürk, Aliye Sağkan; Güzelbekteş, Hasan
Bu olgunun materyalini S.Ü. Veteriner Fakültesi İç Hastalıkları Kliniğine getirilen, yetişkin köpek maması ile beslendiği ve fazla miktarda mama tükettiği bildirilen bir aylık İngiliz Bulldog ırkı yavru köpek oluşturdu. Klinik, laboratuar, radyografik ve endoskopik bulgular ışığında gastrik dilatasyon ve kronik gastritis teşhis edilen olguda, teşhis ve tedavi yaklaşımları değerlendirildi. İştahsızlık, halsizlik, karında şişkinlik, kusma çabaları, sancı, kabızlık, gergin duruş ve sinirsel nöbet şikâyetleri olduğu öğrenilen köpeğin fiziksel muayenesinde bilateral abdominal gerginlik, kolik ve gastrik ağrı tespit edildi. Direkt ve kontrast radyografik incelemede, gastrik dilatasyon dışında anormallik izlenmedi. Yavru köpeğin endoskopik muayenesinde kurvature majör rugal kıvrımlarında belirgin ödem ve kalınlaşma, mukus artışı, hiperemi, mukozal granülarite ve hassasiyet, peteşiyel kanamalar, safra kalıntıları gibi bulguların yanı sıra mukozal bütünlüğün bozulduğu gözlendi. Klinik, hematolojik, endoskopik ve radyolojik muayeneler ışığında, gastrik dilatasyon ve kronik gastritis teşhis edilen yavru köpeğin tedavisi yapıldı. Sonuç olarak, hatalı besleme sonucu gelişen gastrik dilatasyon ve kronik gastritis teşhis edilen yavru köpeğin tedavisinde, gastrik dekompresyon ve lavaj uygulaması yanında sedatif kullanımı ve parenteral beslemenin tedavi sürecine olumlu katkı sağladığı ve yavru köğeğin tamamen iyileştiği değerlendirildi.
Bladder Eversion Caused by Chronic Cystitis in an Arabian Racehorse: A Case Report
(ELSEVIER SCIENCE INC, 2014) Kumas, Cihan; Maden, Mehmet
Bladder eversion is a rare condition and may occur in mares as a result of excessive straining during pregnancy or in the postpartum period. In the present case, bladder eversion was caused by chronic cystitis in a nonpregnant mare. An Arabian racehorse (mare, 3 years old) was admitted to The Racehorse Hospital of the Turkish Jockey Club with a history of lumbar pain, excessive straining, and frequently assuming the urination position. Physical examination revealed the presence of tenesmus, stranguria, passing of small amounts of urine, and a visible mucosal structure at the ventral vulvar commissure during tenesmus. Laboratory findings revealed leucocytosis, increased urine pH, proteinuria, pyuria, and hematuria. Streptococcus equi subsp. zooepidemicus and Escherichia colt were isolated and identified in urine culture. Transrectal ultrasonography revealed thickening of the bladder wall and prolapse of the bladder corpus into the bladder. In the cystoscopic examination, performed following bladder reduction, severe hyperemia, erosion, and ulcers were determined in the bladder mucosa. Chronic cystitis was treated using antibiotics, based on urine culture test results, together with steroids and nonsteroidal anti-inflammatory drugs. Twenty-four hours after the start of treatment, the severity of straining was observed to have decreased, ceasing completely on Day 4, and the bladder returned to its normal position. In this case presentation, bladder eversion caused by chronic bacterial cystitis, diagnosed by clinical, laboratory, ultrasonography, and cystoscopy findings, was evaluated. It was observed that severe inflammation, pain, and straining caused by chronic bacterial cystitis resulted in bladder eversion and that the eversion was corrected with effective medical treatment of the chronic bacterial cystitis. Crown Copyright (C) 2014 Published by Elsevier Inc. All rights reserved.
Blood and Colostrum/Milk Serum Gamma-Glutamyltransferase Activity as a Predictor of Passive Transfer Status in Lambs
(Blackwell Verlag Gmbh, 2003) Maden, Mehmet; Altunok, Vahdettin; Birdane, Fatih Mehmet; Aslan, V.; Nizamlıoğlu, Mustafa
The importance of blood and colostrum/milk serum gamma-glutamyl transferase (gamma-GT) enzyme activity was evaluated to assess passive transfer status in healthy lambs. Thirty Akkaraman sheep (3-6 years old) were used which had normal pregnancy period and the same conditions, and the age of the lambs ranged between 0 and 15 days. Blood and colostrum/milk samples were collected from sheep and lambs after birth, before suckling (0) and after on 1st, 3rd, 7th and 15th days. Serum immunoglobulin G (IgG) concentration was determined by the use of Single Radial Immunodiffusion method. Serum gamma-GT activity was measured, using a commercially available kit in blood and colostrum/milk samples. Correlations were carried out between immunoglobulin and gamma-GT levels. Regression models (simple and multiple) were calculated with significant data. Linear correlation was determined between colostrum/milk gamma-GT activity and IgG concentrations and between serum gamma-GT activity and IgG concentrations in lambs on the 0 day. (r: 0.607, P: 0.001), 1st (r: 0.768, P: 0.001) and the 3rd (r: 0.603, P: 0.001) days and on the 1st (r: 0.637, P: 0.001) and 3rd (r: 0.478, P: 0.012) days in the experiment, respectively. Multivariate regression models were developed to estimate sample IgG concentration. Serum and colostrum/milk IgG concentration could be predicted using the formula: lamb serum IgG = 825 + 0.688 (lamb gamma-GT) + 52 (days); colostrum/milk IgG = 832 + 0.505 (colostrum/milk gamma-GT) - 167 (days). The regression models were moderately accurate in predicting serum IgG concentration (R-2 = 0.51) and colostrum/milk IgG concentration (R-2 = 0.55). Test sensitivity and positive predictive values for serum gamma -GT enzyme activity were found to be 96 and 100% and for colostrum/milk gamma-GT enzyme activity were found to be 100 and 68% to prediction IgG concentration. Serum and colostrum/milk gamma-GT activity can be used to assess passive transfer status of lambs. Along with this, regression models used to calculate serum and colostrum/milk gamma-GT activities found to be useful to estimate sample IgG concentration. The use of serum and colostrum/milk gamma-GT enzyme activity was found useful especially after birth on the 0, 1st and 3rd days.
Clinical Efficacy of Florfenicol in the Treatment of Calf Respiratory Tract Infections
(Royal Netherlands Veterinary Assoc, 2002) Aslan, V.; Maden, Mehmet; Erganis, Osman; Birdane, Fatih Mehmet; Çorlu, M.
This paper reports on a study of the aetiology of calf pneumonia and the clinical efficacy of florfenicol, a new antibiotic in Turkey. Twenty-seven weaned and unweaned calves (13 males and 14 females) between I and 16 months of age brought to the clinics of Selcuk University, Faculty of Veterinary Science. Broncho-alveolar lavage (BAL) fluid samples were taken from the animals diagnosed to have upper respiratory tract infection associated with bronchitis (N=2), bronchitis (N=5), bronchopneumonia (N=4), pneumonia (N=3), pleuropneumonia (N=11), bronchopneumonia plus pulmonary oedema (N=2) based on the results of the clinical and laboratory examinations. Then microbiological isolation and antibiotic culturing were performed. The animals were treated with I ml/15 kg (20 mg/kg) florfenicol (Nuflor(R), DIF) twice within 48 hours via intramuscular injection. At the end of the treatment, 23 of the weaned and unweaned calves were completely healed, I calf had died and 3 calves showed no healing. The results of BAL samples and microbiological examinations of the 3 calves that did not respond to the treatment indicated that these cases were affected by mixed infections of yeasts, fungi, and bacteria. Widespread pleuropneumonia was observed. According to the results of the microbiological examination of the BAL samples, Mannheimia (Pasteurella) haemolytica had the highest isolation rate (25%) compared with the other isolated bacteria, namely, Klebsiella pneumonia (20%), Actinomyces pyogenes (15%), beta-hemolytic streptococci. (10%), Staphylococcus spp. (5%), and E. coli (5%). The study also revealed fungi [Penicillum spp. (5%) and Aspergillus spp. (5%)] and two calves (10%) had a yeast infection.. We conclude that florfenicol has a high bacteriological and clinical efficacy (100% and 96% respectively) in the treatment of calf respiratory tract diseases.
A comparative study on the prevalence of Theileria equi and Babesia caballi infections in horse sub-populations in Turkey
(ELSEVIER SCIENCE BV, 2008) Sevinc, Ferda; Maden, Mehmet; Kumas, Cihan; Sevinc, Muflu; Ekici, Ozlem Derinbay
Blood and serum samples were taken from 481 horses, from a stud farm or a racecourse, and tested by microscopic examination of blood smears and cELISA for Theileria equi (T equi) and Babesia caballi (B. caballi) infections. At the time of sampling, animals were also examined for tick infestations and clinical disease, which were not observed in any of the sampled horses. During the microscopic examination of thin blood smears, parasites were detected in the three horses from the racecourse. Overall seroprevalence of infection was detected as 18.50% (89 of 481 horses) by cELISA, with T equi being significantly more prevalent than B. caballi. Of the 481 blood samples, 78 (16.21%) were serologically positive for T equi and 4 (0.83%) were serologically positive for B. caballi. In addition, 7 (1.46%) samples were positive for both T equi and B. caballi antibodies. Seropositivity rates in the racecourse horses were higher than those determined in the stud farm horses. The rates for T equi, B. caballi and both species were 13.39, 0.52 and 0% in the horses from the stud farm and 27, 2 and 7% in the racecourse horses, respectively. These results indicate that equine piroplasmosis is more common in racehorses than studhorses and therefore it might be a serious concern in horses that participate to international races. (c) 2008 Elsevier B.V. All rights reserved.
Comparison of two different primer sets for detection of Pasteurella caballi in bronchoalveolar lavage fluids samples from thoroughbred Arabian foals, using PCR
(UNIV ZAGREB VET FACULTY, 2016) Sayin, Zafer; Erganis, Osman; Sakmanoglu, Asli; Hadimli, Hasan H.; Pinarkara, Yasemin; Maden, Mehmet; Al Shattrawi, Huda J. G.
In the present study, Pasteurella caballi (P. caballi) was isolated and identified in bronchoalveolar lavage fluid and lung samples from thoroughbred Arabian foals using conventional microbiological methods. Subsequently, the ability of two different PCR primer sets was evaluated for detection and confirmation of P. caballi. Primer sets 1 and 2, targeting the 16S rRNA gene of P. caballi, were designed using the Primer 3 and Primer-BLAST programs, respectively. PCR was performed to confirm P. caballi strains and to detect it directly in the bronchoalveolar lavage fluid and lung samples. In total, 35 Pasteurella spp. were isolated from 25 (38.4 %) of 65 bronchoalveolar lavage fluid samples, and 10 (58.8 %) of 17 lung samples. These strains were identified as P. caballi based on conventional microbiological and biochemical characteristics. The sensitivities of primers 1 and 2 were determined lobe 100 % to confirm cultured P. caballi strains. However, the specificity of P. caballi detection was lower with primer set-1 than primer set-2 in bronchoalveolar lavage fluid and lung samples. The sensitivity and specificity of primer set-2 were confirmed by gene sequence analysis. This study indicates that the 16S rRNA-PCR method, using primer set-2, provides a rapid and accurate tool for the detection and confirmation of P. caballi isolates in bronchoalveolar lavage fluid and lung samples from foals.
Concentrations of total serum immunoglobulin e, a, g and m in stray dogs with healthy and dermatological problems
(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013) Maden, Mehmet; Birdane, Fatih Mehmet; Ucan, Uckun Sait; Altunok, Vahdettin
In this study, clinical and laboratory findings along with serum IgE, IgA, IgM and IgG concentrations were determined in stray dogs (healthy and with dermatological problems). It was determined that skin lesions were localized in the rate of 69.8% (n=44) and generalized in the rate of 30.2% (n=19) of sick animals. Serum IgE concentration in stray dogs with dermatologic problems was significantly higher (P<0.001) than that of healthy dogs whereas serum IgM and G concentrations were significantly lower (P<0.05). It was evaluated that, serum total immunoglobulin concentrations could be useful in making contribution to differential diagnosis of skin diseases in stray dogs.
Cytologic-enzymologic diagnosis of experimental pneumonia induced by klebsiella pneumoniae serotype II in rats and its treatment with free and liposomal enrofloxacin
(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013) Baş, Ahmet Levent; Üney, Kamil; Hadimli, Hasan Hüseyin; Sezer, Ali Demir; Hatipoğlu, Fatih; Maden, Mehmet; Akbuğa, Julide
Enrofloxacin (ENR) rapidly localizes in eukaryotic cells in vitro but does not remain for prolonged periods, thereby reducing the ENR efficacy of defense against intracellular pathogens. Delivery of ENR in a liposome-encapsulated form may enhance its intracellular residence time. In this study, experimental pneumonia was induced in healthy and dexamethasone-treated rats using Klebsiella pneumoniae serotype II. Free and liposome-encapsulated ENR were injected intravenously into the infected animals at a dose of 7.5 mg/kg/day for 5 days. Samples of tissue, plasma and bronchoalveolar lavage (BAL) fluid were obtained at 1, 2, 3 and 4 days and 1, 2, 3 and 4 weeks after the first antibiotic treatment. All of the samples were evaluated cytologically, enzymologically, microbiologically and pathologically. It was determined that cytologic and enzymologic diagnoses of BAL fluid are not meaningful for evaluating the treatment of the experimental pneumonia in rats. However, it was established that the use of ENR in liposomal form at a dose of 7.5 mg/kg for 5 days is more effective than the free form both in the treatment of K. pneumoniae infections and in the prevention of recurrent infections. Liposome-encapsulated antimicrobial agents should provide another choice for antimicrobial therapy in the future, but further investigation must be completed before clinical use.
Deneysel Gentamisin Nefrotoksisitesinde Üriner Enzim Aktivitelerinin Önemi
(1999) Maden, Mehmet; Aslan, Veysi
Totally nine healthy and mature dogs were used in the study. Two of which were served as controls and remaining seven dogs were assigned to experimental group. Gentamicin sulphate was given to induce nephrotoxicity at the dose of 10 mg/kg body weight every 8 hours for 10 consecutive days. The samples of blood and urine were taken twice before the experiment and every other day during gentamicin infection and for 5 days after gentamicin injection was ceased. N-acetyl-?-D-glocosaminidase (NAG). ?-glutamyl transterase (GGT) and Alkaline phosphatase (ALP) and creatinine (CR), total protein (TP), glucose (GLU) and electrolyte (Ca, P, Na, K) concentrations in the urine samples and blood urea nitrogen (BUN), total protein (TP), albumin (ALB), cretainine (SCR), glucose and electrolytes (Ca, P, Na, K) concentrations in the blood samples were measured. Urine dip stick and microscopic examination of urine sediment were performed. Urine protein/creatinine rate and daily protein loss in urine were calculated. The fractionel clearances of electrolytes (Ca, P, Na, K) and glucose were determined. Sodium sulphanilate clearance was measured twice before the experiment and three times during the experiment. Daily clinical examination of all dogs were performed during the experiment. Autopsy and histopatologic examinations were performed in three dogs (1 control, 2 experimental group) on the 11th day of the experiment, two dogs were euthenasied due to uremic coma on the 12th day of the experiment and remaining dogs were necropsied at the end of the experiment. In this study, acute tubular necrosis induced with nephrotoxic doses of gentamicin was found to be occured between 7th and 10th days of the experiment on the basis of clinical and laboratory findings. Urine GGT activities were found to be increased (P<0.01) on the 7th day of the experiment, urine NAG and ALP activities did not significantly increase. Significant increaments in the GGT/CR (P<0.01) and NAG/CR (P<0.01). ALP/CR (P<0.05) rates were observed respectively on the 7th and 13th days of the experiment. In conclusion, GGT/CR rate was found to be the most sensitive and reliable indicator in the determination of renal tubular damage associated with gentamicin nephrotoxicity.
Disseminated metastatic transmissible venereal tumour in a bitch
(Selçuk Üniversitesi Veterinerlik Fakültesi, 2013) Kose, Ayse Merve; Cizmeci, Sakine Ulkum; Aydin, Ibrahim; Dinc, Dursun Ali; Maden, Mehmet; Kanat, Ozgur
Bu vakanın materyalini doğum sonrası üç aydır devam eden kanlı vaginal akıntısı olan 4 yaşlı Sibiryan Husky ırkı dişi bir köpek oluşturdu. Yapılan fiziksel muayenede deri altında birçok noktada çeşitli büyüklükte kitlelerin olduğu, kanlı vajinal akıntının bulunduğu, vulvanın ödemli olduğu ve üzerinde dokunulduğunda kolayca kanayan karnabahar görünümlü frajil tümoral kitlelerin bulunduğu belirlendi. Vaginadaki tümoral kitlelerden hazırlanan smear preperatlarının sitolojik incelemesinde yuvarlak hiperkromik çekirdek ve çekirdekçiği bulunan ince stoplazmalı, eozinofilik vakuollü yuvarlak, oval ya da polihidral görünümlü tipik transmissible venereal tümör hücrelerine rastlandı. Ultrasonografik muayenede ise karaciğer, dalak ve sol böbreğin ekojenitelerinde değişiklik olduğu, karaciğer ve dalağın büyüdüğü ayrıca karaciğer üzerinde çok sayıda dalakta ise bir adet kitle olduğu belirlendi. Yapılan klinik, labaratuar, radyografik ve ultrasonografik muayeneler sonucunda vakada yaygın metastazlı transmissible venereal tümör (TVT) teşhis edildi. Vakanın prognozunun kötü olması nedeniyle hasta uyutuldu. Nekropsi sırasında deri, derialtı, memelerin etrafı, son kosta üzerie, abdomen, akciğer, karaciğer ve dalakta matastazik kitleler belirlendi. Genellikle benign karakterde olan ve metastazlara nadir rastlanılan TVT olgusu, bu vakada deri, derialtı dokular, meme, karaciğer, dalak ve akciğerde metastazlara yol açıp malign karaktere döndüğü belirlendi. Sonuç olarak TVT’li köpeklerde metastaz varlığının araştırılması için dikkatli bir sistematik muayene yapılmalıdır.
Disseminated metastatic transmissible venereal tumour in a bitch
(2013) Kose, Ayse Merve; Cizmeci, Sakine Ulkum; Aydın, Ibrahim; Dınc, Dursun Ali; Maden, Mehmet; Kanat, Ozgur
Bu vakanın materyalini doğum sonrası üç aydır devam eden kanlı vaginal akıntısı olan 4 yaşlı Sibiryan Husky ırkı dişi bir köpek oluşturdu. Yapılan fiziksel muayenede deri altında birçok noktada çeşitli büyüklükte kitlelerin olduğu, kanlı vajinal akıntının bulunduğu, vulvanın ödemli olduğu ve üzerinde dokunulduğunda kolayca kanayan karnabahar görünümlü frajil tümoral kitlelerin bulunduğu belirlendi. Vaginadaki tümoral kitlelerden hazırlanan smear preperatlarının sitolojik incelemesinde yuvarlak hiperkromik çekirdek ve çekirdekçiği bulunan ince stoplazmalı, eozinofilik vakuollü yuvarlak, oval ya da polihidral görünümlü tipik transmissible venereal tümör hücrelerine rastlandı. Ultrasonografik muayenede ise karaciğer, dalak ve sol böbreğin ekojenitelerinde değişiklik olduğu, karaciğer ve dalağın büyüdüğü ayrıca karaciğer üzerinde çok sayıda dalakta ise bir adet kitle olduğu belirlendi. Yapılan klinik, labaratuar, radyografik ve ultrasonografik muayeneler sonucunda vakada yaygın metastazlı transmissible venereal tümör (TVT) teşhis edildi. Vakanın prognozunun kötü olması nedeniyle hasta uyutuldu. Nekropsi sırasında deri, derialtı, memelerin etrafı, son kosta üzerie, abdomen, akciğer, karaciğer ve dalakta matastazik kitleler belirlendi. Genellikle benign karakterde olan ve metastazlara nadir rastlanılan TVT olgusu, bu vakada deri, derialtı dokular, meme, karaciğer, dalak ve akciğerde metastazlara yol açıp malign karaktere döndüğü belirlendi. Sonuç olarak TVTli köpeklerde metastaz varlığının araştırılması için dikkatli bir sistematik muayene yapılmalıdır.
Effect Of Acute Ruminal Acidosis On Riboflavin and Niacin Concentrations In Sheep
(Selçuk Üniversitesi, 1993) Başoğlu, Abdullah; Turgut, Kürşat; Eksen, Mursayettin; Traş, Bünyamin; Maden, Mehmet; Ok, Mahmut; Baş, A. Levent; Keçeci, Tufan
Six nonlactating, nonpregnant adult ewes divided into two groups of 3 animals each as a control and experimental groups were used to evaluate the effect of experimentally induced acute ruminal acidosis on plasma and rumen fluid riboflavin and niacin concentrations. Decreasements in ruminal fluid pH, the count of protozoa and increase in the count of bacteria were related to gradual decreases in plasma riboflavin and niacin concentration. Plasma riboflavin and niacin concentrations decreased respectively from 9.51 mcg/ ml and 7 01 mcg/ml to 0.42 mcg/ml and 0.09mcg / m * l at the first day of the experiment (p < 0.05) and than inclined towards normal values. Similar drastical decrease in the niacin concentration of rumen fluid was determined at the first day of the experiment.
Effect of Phlorhizin-Induced Ketosis on Riboflavin and Niacin Levels in Sheep
(Selçuk Üniversitesi, 1993 Ocak) Başoğlu, Abdullah; Turgut, Kürşat; Eksen, Mursayettin; Traş, Bünyamin; Maden, Mehmet; Ok, Mahmut; Baş, A. Levent; Keskin, Ercan
Six non-lactating, non-pregnant adult ewes divided into two groups of 3 animal each as a control and experimental groups were used to evaluate the effect of phlorhizin-induced ketosis on plasma and rumen fluid riboflavin and niacin concentrations. The mean pH values and the counts of protozoa and bacteria of the rumen fluid in experimental group did not change significantly (p > 0.05) Alteration of plasma riboflavin concentration in experimental group was not significant (p > 0.05) . Whereas both plasma and rumen fluid niacin concentrations decreased from 5.03mcg / m * l and 9.53 mcg / m * l to 2.39mcg / m * l and 2.41 mcg/ml respectively and decraements in both plasma and rumen fluid niacin concentrations were significant (p<0.05).
The Effectiveness of Anti-R. equi Hyperimmune Plasma against R. equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R-equi Vaccine
(HINDAWI LTD, 2014) Erganis, Osman; Sayin, Zafer; Hadimli, Hasan Huseyin; Sakmanoglu, Asli; Pinarkara, Yasemin; Ozdemir, Ozgur; Maden, Mehmet
This study aimed to determine the effectiveness of a pregnant mare immunization of a Rhodococcus equi (R. equi) vaccine candidate containing a water-based nanoparticle mineral oil adjuvanted (Montanide IMS 3012) inactive bacterin and virulence-associated protein A (VapA), as well as the administration of anti-R. equi hyperimmune (HI) plasma against R. equi challenge in the mares' foals. The efficacy of passive immunizations (colostral passive immunity by mare vaccination and artificial passive immunity by HI plasma administration) was evaluated based on clinical signs, complete blood count, blood gas analysis, serological response (ELISA), interleukin-4 (IL-4) and interferon gamma (IFN-gamma), total cell count of the bronchoalveolar lavage fluids (BALF) samples, reisolation rate of R. equi from BALF samples (CFU/mL), lung samples (CFU/gr), and lesion scores of the organs and tissue according to pathological findings after necropsy in the foals. The vaccination of pregnant mares and HI plasma administration in the foals reduced the severity of R. equi pneumonia and lesion scores of the organs and tissue by 3.54-fold compared to the control foals. This study thus indicates that immunization of pregnant mares with R. equi vaccine candidate and administration of HI plasma in mares' foals effectively protect foals against R. equi challenge.
Evaluation of the dynamic (overground) endoscopy procedure in the diagnosis of upper respiratory tract diseases affecting performance of racehorses
(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2013) Kumas, Cihan; Maden, Mehmet
In this study, efficiencies of dynamic (overground) and resting endoscopic examinations were compared in dynamic upper respiratory tract problems which are a cause of poor performance in race horses. Thirty actively-racing horses which were brought to Turkey Jokey Club Racehorses Hospital with poor performance and abnormal respiratory tract sounds were examined while running and rest. The diagnostic effectiveness of dynamic endoscopy and resting endoscopy procedures were compared for the diagnosis of dynamic obstructions of the upper respiratory tract. Dynamic pharyngeal collapse (DPC) in 5 race horses, third or fourth degree of left laryngeal hemiplegia (LLH) in 3 race horses, second degree of axial deviation of aryepiglottic folds (ADAF) in 3 racehorses, rostral displacement of the palatopharyngeal arch (RDPA) in 1 racehorse, and dorsal displacement of the soft palate (DDSP) along with first degree of ADAF in 1 racehorse were detected in the mobile endoscopic exams. Dynamic upper respiratory tract problem was detected totally in 13 horses. As a result, it was observed that dynamic upper respiratory tract problems could be safely detected by dynamic endoscopy and it was superior than routine endoscopic examination in racehorses.
Gezi?ci? Kli?ni?k Uygulamalarının Eği?ti?m ve Öğreti?m Faali?yetleri?ne Katkısının Değerlendi?ri?lmesi? ve Veteri?ner Heki?mli?k Hi?zmetleri?ni?n Geli?şti?ri?lmesi?ndeki? Etki?si?
(Selçuk Üniversitesi, 2004) Maden, Mehmet; Birdane, F. Mehmet; Güzelbekteş, Hasan; Coşkun, Alparslan
Bu araştırmada, ambulans hizmetlerinin Veteriner Hekimlik mesleği ve eğitim-öğretim faaliyetlerine katkısı de ğerlendirildi. Türkiye'de ilk kez uygulamaya konulan bu sistemin değerlendirilmesinde, ambulans hizmetlerinden yararlanan hasta sahipleri, öğrenciler ve klinik öğretim üyelerinin ambulans hizmeti konusundaki gözlemlen ve görüşlerinden yararlanıldı. Araştırma için 1 çekici ve 2 servis ünitesinden (vantreyler) oluşan bir ambulans sistemi dizayn edildi. Maksimum 2 inek taşıyan veteriner ambulans, telefon veya şahsi müracaatlarla mahallinden hastanın getirilmesi, tedavi sonrasında tekrar nakledilmesi işlemlerini gerçekleştirdi. Ambulans ile gelen hastalann kabul, muayene, teşhis, hospitalizasyon ve tedavi uygulamalan klinik öğretim üyeleri ve öğrencilerle birlikte gerçekleştirildi. Araştırma materyalini, bir yıl boyunca Konya ili ve çevresinden telefon veya şahsi müracaatlaria Selçuk Üniversitesi, Veteriner Fakültesi Hayvan Hastanesine başvuran hasta sahipleri (n=71), kliniklerde eğitim gören 4-5. sınıf öğrencileri (n=153) ve klinik öğretim üyeleri (n=28) olmak üzere toplam 252 denek oluşturdu. Ambulans hizmeti, 3 grup halinde düzenlenen deneklerin anket sorulanna verdikleri cevaplara göre değerlendirildi. Ambulans hizmetlerinin kapsami, gözlenen ve beklenen yararlar ile eğitim-öğretim ve bilimsel araştırmalar üzerindeki etkiler incelendi. Sonuç olarak, Veteriner Ambulansın kliniklere gelen hasta sayısını olumlu etkilediği, hasta hayvanların hastaneye ulaş tinimasında çabukluk ve güvenlik sağladığı, hasta sahiplerinin hayvan hastanesine ilgisini artırdığı belirlendi. Kliniklerde eğitim alan öğrencilerin mesleği sevmeler ve tanımalanında yararlı olduğu, klinik öğretim üyelerinin klinik uygulamalardakı materyal eksikliğini azalttığı, klinik eğitimine giyi artırdığı tespit edildi. Ayrıca bilimsel araştırmaların yürütülmesi ve bölgedeki hayvan hastalıklanının değerlendirilmesine katkı sağlayabileceği değerlendirildi. Ambulans hizmetinin geliştirilerek devam etmesi, hizmetin süresinin uzatılması, ambulansta gerekli ekipmanlanın bulunması, ambulans ile birlikte bir Veteriner Hekim gitmesi konulanının yeniden değerlendirilmesi gerektiği sonucuna varıldı.
I?ngiliz Pointer Irkı Bir Köpekte Demodex Canis Kökenli Atipik Dermatitis Olgusunun Başarılı Sağaltımı
(Veteriner Fakultesi Dergisi, 2012) Maden, Mehmet; Er, Cenk; Kav, Kürşat; Özdemir, Özgür
In this case, the diagnosis and treatment of atypical dermatitis caused by Demodex canis was evaluated in a-5 year old English pointer. The disease defined as atypical dermatitis due to clinical, laboratory, bacteriological, parasitological and histopatological results. Demodex canis, ?-hemolytic Staphylococcus aureus and Microsporum canis were isolated and identified on the skin scrapings, biopsy specimens and swab. The dog was treated for 4 months, given bath of ketoconazole and benzoyl peroxide shampoo, twice in a week, ivermectin 0.6 mg/ kg, SC, three days interval, cefaperazone-sulbactam (22 mg/kg, IM) daily for only 10 days and followed by cefquinom (2 mg/kg IM) daily for the rest of the treatment period of 3.5 months, and ketaconazole (10 mg/kg, PO, 4 months) daily. As a result, atypical dermatitis caused by Demodex canis should be treated for longer duration with no complications and with successful outcome at 3 days interval.
İki Köpekte Metastazik Pulmoner Neoplazi Olgusu
(Selçuk Üniversitesi, 1996) Maden, Mehmet; Çiftçi, M. Kemal; Koç, Yılmaz; Hatipoğlu, Fatih
A 12-year old German Shepherd, and 3-year old Tenier showed a metastatic pulmoner neoplasia. German Shepherd and Terrier dogs had a mastectomy, 6 and 13 months prior to death, respectively. Pathological investigation revealed malignant mix neoplasm in German Shepherd, and papillar adenocarcinoma in Terrier. Hematologic and biochemistry profiles were within normal limits except the serum calcium level with a slight increase. Dissemination of neoplasm in mediastinal and inguinal lymph nodes showed the possibility of lenphogenic metastasis in German Shephard. On the other hand no dissemination of neoplastic cells in lymph nodes of Terrier suggested the possibility of metastasis to be via venous circulation.
İneklerde Kalsiyum Enfüzyonlarına Bağlı Kalp Aritmilerinin Önlenmesinde Atropin ve Verapamil'in Etkileri Üzerine Araştırmlar
(Selçuk Üniversitesi, 1990 Ocak) Başoğlu, Abdullah; Turgut, Kürşat; Dinç, D. Ali; Ok, Mahmut; Maden, Mehmet
Cette étude a été effectuée sur 6 vaches sains. Dans le premier etape, la solution de calcium nommé Surcalce a été injectée à chaque animal. Cinq minutes avant la même injection, Verapamil aussi, dans le troissième etape, ont été utilisés. Avant d'administrer et 1 et 30 minutes après avoir administré la solution de calcium, on mesuré le niveau de calcium du serum. Au cours de ces applications, dans le premier etape, on a fixé sinus arret chez 4 vaches, SA et AV bloc chez une vache, paroxysmale tachicardie ventriculaiere chez une vache. En conséquence, en utilisant Atropin et Verapamil ces arythmies de coeur ont été empechées.
İngiliz pointer ırkı bir köpekte Demodex canis kökenli atipik dermatitis olgusunun başarılı sağaltımı
(2012) Maden, Mehmet; Er, Cenk; Kav, Kürşat; Özdemir, Özgür
Bu olgu sunumunda, 5 yaşlı İngiliz Pointer ırkı bir köpekte Demodex canis kökenli atipik dermatitisin teşhisi ve tedavisi değerlendirildi. Klinik, laboratuvar, bakteriyolojik, parazitolojik ve histopatolojik muayeneler ışığında, deri kazıntısı ve deri biyopsisi örneklerinden Demodex canis, ?-hemolitik Staphylococcus aureus ve Microsporum canis izole ve identifiye edilen bu olgu, atipik dermatitis olarak tanımlandı. Banyo uygulaması (ketokonazol ve benzoxyl peroxide şampuan, haftada 2 kez), ivermektin (0.6 mg/kg, SC, 3 gün ara ile, 4 ay), sefaperazon-sulbaktam kombinasyonu (22 mg/kg, 10 gün), cefquinom (2 mg/kg, İM, 3.5 ay) ve ketokonazol (10 mg/kg, oral, 4 ay) ile dört ay boyunca tedavi edildi. Sonuç olarak, Demodex canis kökenli atipik dermatitis olgularında tedavi süresinin uzun tutulması gerektiği ve 3 günlük aralıklarla yapılan ivermektin tedavisinin başarılı olduğu ve herhangi bir komplikasyona neden olmadığı değerlendirildi.

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