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Öğe Acrylamide-treatment and responses to phenylephrine and potassium in rat aorta(AKADEMIAI KIADO RT, 2012) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Esen, H.; Yener, Y.; Oznurlu, Y.Acrylamide (ACR) is a chemical used in many industries around the world and was found to form naturally in foods cooked at high temperatures. The aim of the present study is to evaluate the influence of ACR treatment on vascular responses to phenylephrine (PHE; 10(-9)-3x10(-4) M) and potassium chloride (KCl; 5-100 mM). We also examined the role of gender in these responses. The animals in both genders were divided into three groups as follows. (1) Control animals, (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days), (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Male rat aortas were more sensitive to PHE and KCl than female aortas. ACR-treatment increased the sensitivity to PHE and KCl, in both genders. Compared to the control group, ACR treatment significantly reduced the luminal area of both male and female rat aortas. Furthermore, the responses to PHE and KCl were similar in both 2 mg/kg-d ACR-treated rat aortas with 5 mg/kg-d ACR-treated rat aortas, in both genders. The results of this study suggest that ACR treatment affects vascular contractility and morphology in both gender of rat aorta.Öğe Aerobic and anaerobic exercise performance in female patients with fibromyalgia: Effects of antidepressants(FEDERATION AMER SOC EXP BIOL, 2005) Okudan, Nilsel; Özerbil, O. M.; Gökbel, Hakkı; Levendoğlu, F[Abstract not Available]Öğe Alpha Lipoic Acid Treatment Improved Endothelium-dependent Relaxation in Diabetic Rat Aorta(PHARMACEUTICAL SOC JAPAN, 2011) Okudan, Nilsel; Atalık, Kısmet Esra Nurullahoğlu; Gökbel, Hakkı; Canbilen, A.; Kara, I.The aim of this study was to ascertain the effects of alpha-lipoic acid (ALA) treatment on relaxant responses of acetylcholine (ACh) and isoprenaline (ISO) in aortic rings precontracted with serotonin (5-HT, 10(-6) M) obtained from streptozotocin (STZ) -induced diabetic rats. Diabetes was induced in the rats by 50 mg/kg streptozotocin (STZ) via an intraperitoneal injection. Rat body and aorta weights were measured. The isometric tension to ACh (10(-9)-3 X 10(-6) M) and ISO (10(-9)-10(-4) M) of 5-HT-precontracted diabetic and non-diabetic rat (control), diabetic-ALA-treated, and ALA-treated aortas, in organ baths were recorded. Six weeks after STZ treatment blood glucose was elevated compared to control rats. In aortic rings from diabetic rats ACh and ISO-induced relaxations were impaired whereas endotheliumin-dependent relaxation to sodium nitroprusside (SNP) was unaffected. ALA (100 mg/kg/day) treatment for 5 weeks enhanced ACh and ISO-induced relaxation in diabetic aortas. This recovering effect was via NO because prevented by incubating the vessels with N-G-nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor). It may be assumed that ALA treatment in vivo, can protect against impaired vascular responsiveness in STZ-induced diabetic rats.Öğe Amino asitli diyalizatların malnütrisyonlu SAPD hastalarında nütrisyonel ve diğer laboratuar parametreleri üzerine 1 yıllık dönemdeki etkileri(2009) Güney, İbrahim; Altıntepe, Lütfullah; Okudan, Nilsel; Tonbul, H. Zeki; Türk, Süleyman; Yeksan, MehdiAmaç: Malnütrisyon periton diyaliz hastalarında ciddi bir problemdir ve morbitide-mortalitenin önemli nedenlerindendir. Amino asit içeren peritoneal diyaliz solüsyonları (nutrineal) ile diyaliz yapılan malnütrisyonlu hastalarda nutrisyonel durum ve diğer laboratuar parametrelerindeki değişiklikleri incelemeyi amaçladık. Yöntem: Serum albumin düzeyi 3.5 g/dl olan 19 SAPD hastası çalışmaya alındı. Hastaların bir yıllık takiplerinde; 5 hastanın exitus, 2 hastanın hemodiyalize ve bir hastanın ise APD’ye transfer olması, 2 hastada karın ağrısı, 1 hastada ise bulantı-kusma gelişmesi nedeni ile çalışmadan çıkarıldı. Çalışmayı tamamlayan 8 hastanın (6E/2K), yaş ortalaması 49.511.1 yıl idi. Başlangıç ve 1. yılda serum üre, kreatinin, total protein, albumin, ürik asid, fosfor, total kolesterol, trigliserid, hemoglobin düzeyleri, triseps deri kıvrım kalınlığı (TST), vücut yağ oranı ve vücut kitle indeksi (VKİ) belirlendi. Bulgular: Bir yıllık takip sonrasında ise başlangıç değerlerine göre serum albumin (p0.035), üre (p0.002) değerlerinde ve VKİ’de (p0.011) anlamlı artış saptanırken, ürik asit (p0.009) ve trigliserid (p0.004) değerlerinde anlamlı bir düşüş saptandı; diğer parametrelerde ise anlamlı bir fark saptanmadı. Sonuç: Amino asitli diyaliz solüsyonlarının malnütrisyonu bulunan SAPD hastalarında malnütrisyonu düzeltmek için kullanılabileceği kanaatindeyiz.Öğe The application of the critical power test in two different ways(FEDERATION AMER SOC EXP BIOL, 2005) Gökbel, Hakkı; Okudan, Nilsel[Abstract not Available]Öğe The association between irisin levels, element distribution and oxidative stress markers in adolescent swimmers(WALTER DE GRUYTER GMBH, 2018) Belviranli, Muaz; Okudan, Nilsel; Karakuyu, NuranThe objective of this investigation was to compare irisin concentration and its relation with oxidative stress markers, antioxidant enzymes and element levels in both male adolescent swimmers and sedentary controls. Twelve male swimmers aged between 11 and 18 years, who performed regular swimming training for at least 2 years and 12 age- and gender-matched sedentary controls participated in this study. After anthropometric measurements were performed, fasting venous blood samples were taken at rest. Irisin, malondialdehyde (MDA) as a marker of oxidative stress, superoxide dismutase (SOD) as a marker of antioxidant enzyme and elements (Zn, Cu, Se, Cr, Ni, Al, Fe) were analyzed in these samples. MDA levels were lower but Zn levels and Zn/Cu ratio were higher in the swimmers than in sedentary controls (p < 0.05). There was no statistically significant difference in the irisin levels and SOD activities between the groups (p > 0.05). The results of the current study suggested that exercise training has antioxidant effects and may reduce oxidative damage. Exercise training has also limited effects on irisin levels in the adolescents.Öğe Association between pentraxin-3 and growth differentiation factor-15 in adolescent male swimmers(WILEY-BLACKWELL, 2015) Karakuyu, Nuran; Belviranli, Muaz; Okudan, Nilsel[Abstract not Available]Öğe The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis(ELSEVIER IRELAND LTD, 2008) Akpınar, Zehra; Tokgöz, Serhat; Gökbel, Hakkı; Okudan, Nilsel; Uğuz, Faruk; Yılmaz, GülsümThe association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD). The sample comprised 13 patients with MD and 12 with no psychiatric disorders admitted to our clinic due to acute MS attacks. Psychiatric evaluation was performed with the Structured Clinical interview for DSM-IV (SCD-I). The level of depressive symptoms was assessed with the Beck Depression Scale (BDS). Blood samples were taken from the patients to determine melatonin level at 03.30h and 10.00h before steroid treatment started. Melatonin levels were determined using the ELISA test. Nocturnal serum melatonin levels (21.2 +/- 17.1 pg/ml) of the patients with MD were significantly lower than those (51.5 +/- 18.3 pg/ml) of the patients without MD. A significant negative correlation was found between BDS scores and nocturnal serum melatonin levels. These findings suggest that a melatonin deficiency may be among the factors involved in the occurence of depression in MS patients. (c) 2007 Elsevier Ireland Ltd. All rights reserved.Öğe Astrand-Rhyming nomogramının ve Fox eşitliğinin değerlendirilmesi: Anaerobik eşikle ilişkiler(2005) Gökbel, Hakkı; Okudan, Nilsel; Gül, İbrahim; Üçok, KağanAmaç: Astrand-Rhyming nomogramı ve Fox eşitliğinin geçerliliğini değerlendirmek ve bu yöntemlerin anaerobik eşik tahmini için kullanılıp kullanılamayacağını belirlemek. Yöntem: 15 sedanter, 7 antrenmanlı genç erkeğe bisiklet ergometresinde maksimal egzersiz testi uygulandı. Başlangıç yükü 60-100 W idi ve yük, tükenmeye kadar dakikada bir 10 W artırıldı. VO2max, üç farklı ventilatuvar eşik ve kan birikiminin başlangıç noktası hesaplandı. VO2max, 6 dakika süreyle uygulanan önceden belirlenmiş bir yükten ve testin sonundaki kalp hızından (Astrand-Rhyming nomogramı) ve 150 W yükteki bir bisiklet egzersizinin 5. dakikasında kaydedilen yükten (Fox eşitliği) tahmin edildi. Bulgular: Sedanterlerde doğrudan ölçülen VO2max, Astrand-Rhyming nomogramı ile ve Fox eşitliğiyle tahmin edilen VO2max ile ilişkiliydi. Anaerobik eşikler Fox eşitliğiyle tahmin edilen VO2max’la doğrudan ölçülen VO2max’a göre genellikle daha fazla ilişkiliydi. Sonuç: Ölçülen VO2max, Astrand-Rhyming nomogramıyla ve Fox eşitliğiyle tahmin edilen VO2max ile ilişkili olmadığı için VO2max’ın sporcularda indirekt yolla ölçülmemesi gerektiği sonucuna varıldı. Anaerobik eşik parametreleri ile daha fazla ilişkili olduğundan, anaerobik eşik tahmininde Fox eşitliğini kullanmanın daha uygun olacağını düşünüyoruz.Öğe Behçet Hastası Kadınlarda Solunum Fonksiyon Testleri(2001) Uysal, Hüseyin; Balevi, Şükrü; Okudan, NilselAmaç: Bu çalışmada, Behçet hastalığı bulunan kadın hastaların solunum fonksiyonlarında önemli bir değişikliğin olup olmadığının incelenmesi amaçlandı. Yöntem: Çalışmaya yaşları 19 - 50 arasında (ort. 36.4 9.0) olan 14 kadın hasta ile yaşları 19 - 49 arasında (ört. 37.4 10.1) olan 14 sağlıklı kadın alındı. Hasta ve kontrol grubunun fiziki muayeneleri yapıldı, Yüksek Rezonanslı Bilgisayarlı Tomografileri (YRBT) çekildi ve Sensormedics Sistem 2400 sulu spirometre ile solunum fonksiyon testleri (SFT) yapıldı. Bulgular: Hasta ve kontrol grubuna ait çoğu SFT değerlerinde (FVC, FEF%25-75, FEF%75-85, FEF%50, PEF, VC, RV ve FRC) gerek elde edilen en iyi değerler ve gerekse beklenen değerlere yüzde oranlar açısından anlamlı bir fark bulunmadı. Ancak, FEVı, TLC ve DLCO değerlerinin beklenen değerlere göre yüzde oranı hasta grubunda daha düşük bulundu. Hastaların solunum sistemleri hakkında bilgi edinmek amacıyla çekilen YRBT'lerinde 4 hastada bazı patolojik değişiklikler tespit edilirken diğer hastalarda önemli bir patolojik bulguya rastlanmadı. Sonuç: Behçet hastalığında akciğer tutulumu seyrek görülmesine rağmen bazı SFT (FEVı, TLC ve DLCO) değerlerinde kontrol grubuna göre anlamlı şekilde düşüktür. Bu nedenle, YRBT değerlendirmelerinde patolojik akciğer bulguları bulunan kadın Behçet hastalarının yanı sıra patolojik akciğer bulguları bulunmayan hastalarda da solunum fonksiyon testlerinin belirli periyotlarla yapılmasının hastalığın takibinde faydalı olacağı kanaatindeyiz.Öğe Changes in Lipid Peroxidation and Antioxidant Capacity During Walking and Running of the Same and Different Intensities(Lippincott Williams & Wilkins, 2010) Balcı, Şükrü Serdar; Okudan, Nilsel; Pepe, Hamdi; Gökbel, Hakkı; Revan, Serkan; Kurtoğlu, Firuze; Akkuş, HasanBalci, SS, Okudan, N, Pepe, H, Gokbel, H, Revan, S, Kurtoglu, F, and Akkusx, H. Changes in lipid peroxidation and antioxidant capacity during walking and running of the same and different intensities. J Strength Cond Res 24(9): 2545-2550, 2010-The aim was to investigate the changes in lipid peroxidation, antioxidant enzyme activities, and muscle damage in the same and different exercise intensities during walking and running. Fourteen healthy males participated in this study. The subjects' individual preferred walk-to-run transition speeds (WRTS) were determined. Each subject covered a 1.5-mile distance for 4 exercise tests; walking (WRTS-W) and running (WRTS-R) tests at WRTS, 2 km.h(-1) slower walking than WRTS (WRTS-2) and 2 km.h(-1) faster running than WRTS (WRTS+2). Blood samples were taken pre, immediately, and 30 minutes post each test. The changes in (MDA) and glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), and creatine kinase activities were measured. Oxygen uptake, carbon dioxide output, oxygen uptake per kilogram of body weight, and heart rate during exercises were significantly higher in both the WRTS-W and the WRTS+2 exercises compared with the WRTS-2 and WRTS-R. Oxygen consumption and energy expenditure were higher in walking than in the running exercise at the preferred WRTS and only WRTS-W exercise significantly increased MDA levels. Catalase activities were increased by WRTS-W, WRTS-R, and WRTS+2 exercises. Changes in SOD and CAT activities were not different between walking and running exercises at the preferred WRTS. Total plasma GSH increased in response to WRTS-W exercise, which could be associated with an increase in MDA. Also, total GSH levels 30 minutes postexercise were significantly lower than postexercise in WRTS-2, WRTS-W, and WRTS+2 exercises. Our results indicate that walking and running exercises at the preferred WRTS have different oxidative stress and antioxidant responses.Öğe Changes in serum leptin levels in strenuous exercise and its relation to zinc deficiency in rats(HUMANA PRESS INC, 2005) Gökbel, Hakkı; Baltacı, A. K.; Uçok, K; Okudan, Nilsel; Moğulkoç, RasimThis study aimed to investigate the possible changes in serum leptin concentration caused by acute exercise and the effects of zinc deficiency on these changes. Forty male rats were divided into control-control, control exercise, zinc-deficient-control, and zinc-deficient-exercise groups (10 rats in each). Control-exercise and zinc-deficient-exercise groups performed exercise at 6 m/min speed on a rodent treadmill for 60 min or until exhaustion. All rats were decapitated 48 h after the exercise, and blood samples were collected to determine serum leptin and zinc levels. Serum leptin levels in the exercise groups were lower than in the control groups. Leptin levels in the zinc-deficient-control group were lower than in the control control group. The mean exercise time of control-exercise group was significantly longer than the zinc-deficient-exercise group. We conclude that serum leptin levels significantly decrease both 48 h after strenuous exercise and in the zinc-deficient rats, and there is a further decrease in leptin levels when rats fed on a zinc-deficient diet performed exercise.Öğe Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women(TAYLOR & FRANCIS LTD, 2016) Celik, Feyza; Belviranli, Muaz; Okudan, NilselThe roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obese and non-obese women. The study included 83 women who were divided into four groups based on menopausal status and body mass index. The leptin level was significantly higher in the obese women than in the non-obese women (p<0.05), but did not differ significantly between pre- and postmenopausal women (p>0.05). The nesfatin-1 and kisspeptin-1 levels did not differ significantly between any of the study groups (p>0.05). The present findings show that nesfatin-1 and kisspeptin levels are not affected by obesity or menopausal status.Öğe Coenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: Conduction velocity distributions(PROUS SCIENCE, SAU-THOMSON REUTERS, 2008) Ayaz, Murat; Tuncer, Seckin; Okudan, Nilsel; Gokbel, HakkiDiabetic neuropathies are a family of nerve disorders caused by diabetes. Patients with diabetes can develop nerve problems at any tune, but the longer a person has diabetes the greater the risk. This study aims to investigate diabetes- and coenzyme Q(10) (CoQ(10)) or alpha-lipoic acid (ALA) supplementation-induced changes in the conduction velocity (CV) distributions of rat sciatic nerve fibers. Sciatic nerve compound action potentials (CAPs) were recorded by suction electrode and CV distributions by the collision technique. Diabetes resulted in a significant increase in time to peak, rheobase and chronaxie values of these CAP waveforms, whereas the maximum depolarization, area, kinetics and CVs of both fast and slow nerve fiber groups were found to be decreased, Coenzyme Q(10) (CoQ(10)) supplementation was found to have some positive effect on the diabetes-induced alterations. CoQ(10) supplementation induced positive changes mainly, in the area and fall-down phase of the kinetics of CAP waveforms, as well as rheobase. chronaxie and speed of the intermediately conducting groups (congruent to 40 m/s). alpha-Lipoic acid (ALA) supplementation did not produce statistically significant effects. This stud), has shown for the first tune that diabetes induces a shift of actively contributing nerve fibers toward slower CVs(10) and supplementation with CoQ(10) not only stopped this shift but also tended to restore velocities toward those of the age-matched control group. In addition to its effects on mitochondrial alterations, these positive effects of CoQ(10) on diabetic neuropathy) can be attributed to its antioxidant activity Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.Öğe Coenzyme Q(10) and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Disease(INFORMA HEALTHCARE, 2011) Gokbel, Hakki; Atalay, Huseyin; Okudan, Nilsel; Solak, Yalcin; Belviranli, Muaz; Turk, SuleymanRationale and objectives: Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease. Material and methods: Forty patients with CKD (stages 3--5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined. Main findings: There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. Principal conclusion(s): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.Öğe Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men(EDIZIONI MINERVA MEDICA, 2018) Okudan, Nilsel; Belviranli, Muaz; Torlak, SavasBACKGROUND: The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of 21 sedentary and healthy young men participated. METHODS: Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo. After the 4-week period, the same measurements and blood sampling were taken. At this point, eccentric exercise protocols (90 degrees flexion and 180 degrees extension, velocity 60 degrees/s) were instigated for all subjects in isokinetic exercise dynamometry. After exercise, blood samples were taken immediately, 24, and 48 hours later. Blood samples were analyzed for plasma CoQ10 levels, serum creatine kinase (CK) activities, myoglobin (Mb) levels, plasma total superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels. RESULTS: Plasma CoQ10 levels were higher in the CoQ10 supplemented group than in the placebo group (P<0.05). CK activities and levels of Mb increased in both groups 24 and 48 hours after exercise (P<0.05), but no significant difference between the groups was observed (P>0.05). Plasma total SOD activity and MDA levels were not significantly different in both groups 24 and 48 hours after exercise (P>0.05). CONCLUSIONS: CoQ10 supplementation does not prevent exercise induced muscle damage and oxidative stress in sedentary young men.Öğe Coenzyme Q10 supplementation and regular physical exercise affect the level of glutathione and superoxide dismutase in the brain(2013) Revan, Serkan; Okudan, Nilsel; Balcı, Şükrü Serdar; Belviranlı, Muaz; Pepe, Hamdi; Gökbel, HakkıObjective: The aim of the study was to evaluate the effects of coenzyme Q10 supplementation (CoQ10) and regular exercise on exhaustive-exercise induced oxidative stress and antioxidant response in rat brain. Materials and Methods: The experiments were carried out with young adult male Wistar rats. The rats were randomly assigned to one of the following eight groups: Untrained, trained, untrained exhausted, trained exhausted, untrained+CoQ10, trained+CoQ10, untrained exhausted+CoQ10 and trained exhausted+CoQ10. The rats in the trained groups swam for 60 min/day, five days per week for six weeks. The CoQ10 supplements were administered at a daily dose of 10 mg.kg-1 of body weight five days/week. Results: The levels of malondialdehyde and 8-hydroxydeoxyguanosine in the brain were not affected by exhaustive exercise, training and CoQ10 supplementation. The exhaustive exercise decreased GSH levels in the control group, while it increased in untrained and trained exhausted+CoQ10 groups. Swimming training increased SOD activity in the brain, but exhaustive exercise did not change its activity. CoQ10 supplementation increased SOD activity in control group, while it decreased in the trained group. Conclusion: The results suggested that exhaustive exercise does not cause lipid peroxidation and DNA damage in the brain. It can be said that regular exercise alone may be adequate for the positive effects on antioxidant enzymes in brain. © 2013 by Erciyes University School of Medicine.Öğe The comparison of anaerobic components of critical power and wingate tests applied with two different loads(FEDERATION AMER SOC EXP BIOL, 2005) Gökbel, Hakkı; Okudan, Nilsel[Abstract not Available]Öğe The comparison of preemptive analgesic effects of curcumin and diclofenac(COMENIUS UNIV, 2014) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Öz, MehmetObjective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg(-1), p.o.) and diclofenac (10 mg kg(-1), i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcunnin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.Öğe Comparison of the Effects of Two Antidepressants on Exercise Performance of the Female Patients With Fibromyalgia(Springer, 2006) Özerbil, Önder; Okudan, Nilsel; Gökbel, Hakkı; Levendoğlu, FundaObjective: To compare the effects of two antidepressants on exercise performance of the female patients with fibromyalgia. Methods: Fifteen patients with fibromyalgia participated in this randomized, double-blind crossover study composed of two trials separated by a 2-week washout phase. The pharmacy randomly assigned patients to two groups: (a) placebo (glucose) in the morning and 25 mg amitriptyline at bedtime or (b) 20 mg fluoxetine in the morning and placebo at bedtime. The VO2max and Wingate anaerobic test were evaluated. Within 24 h after 15-day medication, the tests were repeated. Results: Peak power and fatigue index increased, and VO2max and VT did not change with both fluoxetine and amitriptyline. Mean power significantly increased after fluoxetine but not after amitriptyline. Conclusion: Both amitriptyline administration and fluoxetine administration in patients with fibromyalgia have beneficial effects on anaerobic performance. These effects may be important in life quality of the female patients with fibromyalgia.
