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Öğe 1985 - 1986 Yılları Arasında S. Ü. Veteri?ner Fakültesi Kliniklerine Getirilen Hayvanların I?ç Hastalıklar Yönünden Genel Analizi(Selçuk Üniversitesi, 1987 Ocak) Aslan, Veysi; Tiftik, Ali MuhtarIn this article an information was given about the types of diseases, the systems where they are located, their distribution based on the seasons and the animal species, the origines and the causes of diseases related to a total of 1060 animals that was brought to the clinics of the Veterinary Faculty Selçuk Üniversity in 1985-1986. The distribution rate of diseases was found to be as 34.8% in horse, 16.2% in cow, 36.9 % in calf, 6.2 % in sheep and 5.7% in cat and dog. In the region, the infections of the respiratory system were significantly higher. In fact, the tuberculosis, enzootic pneumonia, viral pneumonia and influenze were more common among these diseases. Furthermore several zoonotic diseases such as malleus and brucellosis, calf septisemia, parasitic disease and other disorders related to mineral and vitamin deficiency were also observed.Öğe Buzağılarda Eksperi?mental Kolibasilloz'un Esha Calvasid 60, Esha Calvasid ve Cholostral Suplement ile Tedavisi Üzerinde Araştırmalar(Selçuk Üniversitesi, 1987 Ocak) Aslan, Yeysi; Sezen, Yavuz; Erganiş, Osman; Tiftik, Ali Muhtar; Kaya, OsmanTwelve calves about one week old, were used in this study. Milk replacer was given with special bucket. Before inoculating E. coli strains, the calves were examined clinically and pocket cell volume (PCV), total leucocyt number, serum urea, Na, K, inorganic P and total protein were determined in blood samples. All of these blood parameters were found in normal values. Each calves was given orally 40 ml. enterotoxigenic (10-bacterins/ ml.) and 2 ml. invasion (10 bacterins/ml.) E. coli strain for occuring experimental colibasillosis. All calves were examined clinically and their blood samples were taken for determining blood parameters at 1st, 12th, 36th hour of infection. At 12th hour of infection clinical signs were observed. They were fever, lock of appetite, mild diarrhoea and increased pulse and respiratory rate. At 36th hour these clinical findings were became severe. At the same time PCV, total leucocyt, serum urea levels were increased and Na level was decreased significantly. However, the total protein, K and P values were not affected. After the observation of these sing the calves were divided into three groups: The control, Esha Calvasid Superasid and Cholostral Suplement groups. The calves in control group were given 150g/1 water Esha calvasid 60, the calves in other treatment group were given 125g/1 water Esha calvasid superasid and the third group was fed 50 ml. cholostral suplement/1 milk. Only one calf in control group died and other calves in control group were treated with cholostral suplement. The calves in both treatment group were returned to their normal health.Öğe A comparative investigation of anti-Mullerian hormone (AMH) and various biochemical parameters in patients with cryptorchidism, oligospermia, or varicocele(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2012) Akdağ, Turan; Tiftik, Ali Muhtar; Sarıyıldız, LeventAim: To investigate the serum AMH and various biochemical parameter levels in patients with cryptorchidism, oligospermia, or varicocele. Materials and methods: This study included 100 participants, divided into 5 groups: cryptorchidism (n = 20), varicocele (n = 20), oligospermia (n = 20), and 2 control groups [control 1,8-12 years old (n = 20) and control 2, 18-24 years old (n = 20)]. Using the blood samples drawn from both patient and control groups, AMH, testosterone, FSH, LH, and prolactin parameters were investigated. Results: AMH values measured were found to be 73.04 +/- 44.5 ng/mL and 84.81 +/- 59.1 ng/mL in 20 children with cryptorchidism and 20 healthy children (both groups aged between 8 and 12 years), respectively (P = 0.56). In the present study, AMH values were found to be 5.19 +/- 4.9 ng/mL and 7.66 +/- 5.6 ng/mL in 20 patients with oligospermia and 20 healthy individuals (both groups aged between 18 and 24 years), respectively (P = 0.10). AMH values in 20 patients with varicocele and 20 healthy controls aged between 18 and 24 years were determined to be 7.15 +/- 5.8 ng/mL and 7.66 +/- 5.6 ng/mL, respectively (P = 0.82). No significant P values were determined, but the decrease in values was remarkable. Conclusion: New studies with larger number of participants are needed in order to determinate AMH levels in patients with varicocele, cryptorchidism, or varicocele for diagnostic criteria.Öğe Effect of pinealectomy on homocysteine levels in ovariectomized rats(MAGHIRA & MAAS PUBLICATIONS, 2007) Öztekin, Esma; Öztürk, Bahadır; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Tiftik, Ali MuhtarOBJECTIVE: Hyperhomocysteinemia plays a role in obstetric and gynecological diseases and such diseases are seen as a consequence of an impaired methionine cycle. In the present study, it was aimed to determine the effect of estradiol and progesterone on homocysteine levels in pinealectomized and ovariectomized rats. MATERIALS AND METHODS: The study was carried out on 24 adult Spraque-Dawley female rats. Rats were divided into 4 groups as follows: Group 1: Sham ovariectomy group (Sham-Ovx), Group 2: Ovariectomized and sham pinealectomized group (Ovx-Sham-Px), Group 3: Ovariectomized and pinealectomized group (Ovx-Px), Group 4: Group which were supplemented with estradiol and progesterone after ovariectomy and pinealectomy (Ovx-Px-E+P). Serum homocysteine levels were determined after experimental period. RESULTS: Homocysteine levels in Group 3 were higher than those in Groups 1, 2 and 4 (p<0.05). Homocysteine levels in Groups 2 and 4 were higher than those in Group 1 (p<0.05). Homocysteine levels in Groups 2 and 4 were not different. CONCLUSION: The findings of the present study demonstrate that ovariectomy lead to increases homocysteine levels. Pinealectomy in addition to ovariectomy increases homocysteine levels. However, administration of estradiol and progesterone following pinealectomy prevents the increase in homocysteine levels in ovariectomized rats.Öğe The effects of exogenous estradiol and progesterone with melatonin on homocysteine levels in ovariectomized rats(INDIAN VETERINARY JOURNAL, 2007) Öztekin, Esma; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım; Öztürk, Bahadır; Tiftik, Ali MuhtarHomocysteine, a product of methionine cycle, plays a role in obstetric and gynaecological diseases and these diseases are considered as a result of impaired methionine cycle (Obsweger et al., 1994). Estrogen is considered a nongenetic factor influencing homocysteine metabolism (Pines et al., 1997) Homocysteine levels can be a risk factor for arteriosclerosis and osteoporosis (El-Swefy et al., 2002). El-Swefy et al., (loc. cit) found that high homocysteine levels in ovariectomized rats decreased with estradiol and folic acid supplementation. The aim of this study was to investigate effect of replacement of estradiol, progesterone and melatonin on homocysteine levels in ovariectomized rats.Öğe Farklı Düzeylerde Askorbik Asit İhtiva Eden Rasyonların Yumurta Tavuklarında Verim ve İmmünite Üzerine Etkileri(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 1998) Coşkun, Behiç; İnal, Fatma; Erganiş, Osman; Kuyucuoğlu, Yahya; Ok, Ümran; Çelik, İlhami; Tiftik, Ali Muhtar: This research was carried out in two experiments. In first experiment, three different levels of vitamin C (0, 50 and 100 mg/kg feed) were added the diets based on corn, and the effects of the diets on egg yields, blood vitamin levels, T-lymphocyte percentage, plasma cell count in spleen and antibody titers against the vaccine of Newcastle disease were investigated for one year. Total of 648 laying hens were used in this experiment. The group fed the diet added 50 mg/kg vitamin C, produced less egg and fed more feed for one kg egg than other groups. There were no obvious differences among groups at the antibody titers, the ratio of T-lymphocyte and blood vitamin C levels. In the second experiment twentyfour chiks for each group were supplied by hatching eggs from the hens used in experiment I in order to investigate maternal immunity. Antibody titers were determined at day 2, 7 and 10. At same day, for histologic investigation, blood and some lenfoid tissue samples from spleen, bursa Fabricii, tymus and ileum were taken at same days. The effects of different vitamin C levels were not significant on the antibody titers and histologic results.Öğe Farklı Düzeylerde Askorbik Asit İhtiva Eden Rasyonların Yumurta Tavuklarında Verim ve İmmünite Üzerine Etkileri(1998) Coşkun, Behiç; İnal, Fatma; Erganış, Osman; Kuyucuoğlu, Yahya; Ok, Ümran; Çelik, İlhami; Tiftik, Ali Muhtar; Kurtoğlu, FiruzeÇalışma iki deneme halinde yürütülmüştür. Birinci denemede üç farklı düzeyde C vitamini (0, 50 ve 100 mg/kg) ilave edilen ve büyük oranda mısıra dayalı rasyonların yumurta tavuklarında verim ve Newcatle aşısına karşı oluşan antikor titreleri üzerine etkileri incelenmiş ve toplam 648 adet yumurtacı hibrit tavuk kullanılmıştır. 50 mg vitamin C verilen C2 grubunun diğer iki gruba göre daha düşük yumurta verimine sahip olduğu ve bir kg yumurta üretimi için daha fazla yem tükettiği gözlenmiştir. Bir yıl süren denemede 11 farklı zamanda kanda Hemaglutinasyon Inhibisyon (HI) testi ile antikor titreleri belirlenmiştir. Farklı zamanlarda alınan örneklerde ise kanda T-lenfosit yüzdesi ile dalakta plazma hücre sayısı ve serum vitamin C düzeyleri tayin edilmiştir. İncelenen bu kriterler bakımından gruplar arasında belirgin farklılıklar tespit edilmemiştir. İkinci denemede farklı düzeylerde C vitamini ihtiva eden rasyonlarla beslenen ve I. denemede yer alan her gruptan 24 civciv elde edilerek maternal bağışıklık incelenmiştir. Civcivlerden 2., 7. ve 10. gün alınan kan örneklerinde antikor titreleri belirlenmiş ve dalak, bursa Fabricii, timus ve ileum gibi lenfoid organlardan alınan doku örneklerinde histolojik incelemeler yapılmıştır. Bu denemede örnek alım yaşına bağlı olarak değişimler gözlenmesine karşılık farklı vitamin düzeylerinin gruplar arasında farklılık oluşturmadığı gözlenmiştir.Öğe I?nvi?tro Soğan Yağı Uygulamasının Plazma Kolesterol ve Gli?koz Düzeyleri? ile Bazı Hematoloji?k Parametreler Üzeri?ne(Selçuk Üniversitesi, 1995 Nisan) Durgun, Zafer; Keskin, Ercan; Tiftik, Ali Muhtar; Keçeci, Tufan; Haliloğlu, SeyfullahIn this study, ten dogs, 6-8 months aged, were used. All dogs were fed normal diet plus cholesterol powder for ten days. At the end of the period, the means plasma cholesterol levels increased from 64. 60 to 230. 20 mg/ dl. Hypercholesterolemia didn't cause deformation in erytrocytes shapes. Then, ten blood samples taken from all the dogs were divided equally into two groups as control and experimental. Two hours after as in vitro 0. 2 ?l of onion oil addition to each 10 ml of blood sample in experimental group, plasma cholesterol levels in experimental and control groups decreased from 238. 20, 180. 40 and 171. 60 mg/dl respectively. Plasma glucose levels in experimental group decreased significatly as compared to control group after onion oil administration (P<0.05). After in vitro onion oil administration to experimental group, erytrocytes shapes showed deformation and crenation due to Heinz body formation resulting obviously falling in erytrocytes count, haemoglobine amount and haematocrit values in comparison with control group. Consequently, in this investigation, it was determined that onion oil had no effect on plasma cholesterol levels whereas reduced plasma glucose levels and had haemolytic effect on erytrocytes.Öğe I?zmi?r Bölgesi? Koyunlarında Kan Serumu Bakır (Cu), Demi?r (Fe) Total Demi?r Bağlama Kapasi?tesi? (TDBK) ve Çi?nko (Zn) Düzeyleri?ni?n Araştırılması(Selçuk Üniversitesi, 1997 Ocak) Tiftik, Ali Muhtar; Doğanay, Selma ÇınarIn this research designed for determining Cu, Fe, Total iron binding capacity (TIBC) and Zn levels of blood serum of the healthy ewes grazed in the meadows in Izmir Region, a total of 250 units of blood-samples, being from at least 10 ewes in each herd, were collected from different 15 herds belonging to various villages of some different counties of Izmir (Karşıyaka, Seferihisar, Torbalı, Kemalpaşa, Uria) After eliminated sera that shows haemolyses, cop per (Cu), Iron (Fe), Total Iron Binding Capacity (TIBC) and Zinc levels were analyzed by atomic absorption spectrophotometer in 210 sera.In the assessments respect to serum Cu, Fe, TIBC and Zn leves, considerable diversitiesbeing at p< 0.01 levels-from the statistical point of view were observed between the average values of the counties and herds Although there were considerable differences from county to county, the average values of these counties and herds that indicated the lowest values in respects of iron and zinc contents, were found to be either similar to or just over the normal values. Therefore, it can be stated that the meadows of the counties in questions are rich enough in the elements investigated, and so, there is no need for adding those elements in to ewes rations. In the result of the assessment considering only the copper content, the average serum copper-level of the ewes from Torbalı County of Izmir was found to be remarkably lower, with a rate of p<0.01, than those from other counties. This level is actually lower than the limits of normal values. The average values of only one among the herds in Torbals and 54.54% rate of the entire ewes when considered the individual values, have been found to be lower than the deficiency limit. Under the light of all these findings, taking apart the fact that no soil and plant analyses were executed during the research, we can claim that the meadow soil and plant levels in this county lack in copper and the rations of those animals grazing at meadows are required to be reinforced with copper content.Öğe The Investigation of Biocompatibility and Apical Microleakage of Tricalcium Phosphate Based Root Canal Sealers(WILLIAMS & WILKINS, 1997) Bilginer, Suzan; Esener, Timur; Söylemezoğlu, Figen; Tiftik, Ali MuhtarThe biocompatibility and apical microleakage of tricalcium phosphate based Sankin Apatite (SA) Type I, II, and III root canal sealers were investigated, Teflon tubes containing freshly mixed test materials were implanted in the subcutaneous tissue of mice, The observation periods were 24 h, 7, and 30 days, after which the areas of tissue reaction to the implanted materials were histopathologically analyzed, A dye-recovery, spectrophotometric method was used to evaluate apical microleakage. Results showed that the severity of tissue reaction among the tested materials decreased with time and at the end of the observation period both SA Type II and Type III were found more biocompatible than either Type I or Grossman's cement (GC), On the other hand, a fibrous tissue capsule was seen around the implants, There was no significant difference in spectrophotometrically measured leakage among teeth obturated with the test materials.Öğe Is there any association between serum iron and copper levels in hemadialysis patients?(2009) Sivrikaya, Abdullah; Menevşe, Esma; Tiftik, Ali Muhtar; Tonbul, ZekiÇalışmanın amacı, hemodiyaliz hastalarında serum demir (Fe), bakır (Cu) ve ferritin düzeylerindeki değişiklikleri tespit etmek ve ferritin düzeyleri ile elementler arasında bir ilişkinin olup olmadığını belirtmekti. Çalışmaya 2-16 yıldır diyalize giren (yaş ortalaması 50.2616.36) 47 hemodiyaliz hastası (hemodiyaliz grubu) ve 23 sağlıklı kişi (yaş ortalaması 39.52ill.54) (kontrol grubu) dâhil edildi. Hemodiyaliz grubunda kan numuneleri diyaliz öncesi ve sonrası alındı. Veriler, gruplar arasında serum Fe düzeyleri bakımından önemli bir fark bulunmadığını gösterdi. Ancak, diyaliz öncesi Cu düzeyleri ve de diyaliz öncesi ve sonrası ferritin düzeyleri kontrol grubuna göre daha yüksekti (sırasıyla p0.05, p0.001). Diyaliz öncesi ferritin-Fe (r 0.373, p0.05) ve Fe-Cu (r 0.410, p0.01) düzeyleri arasında önemli pozitif korelasyon bulundu. Bu çalışmadan elde edilen bulgular, serum Cu düzeylerindeki değişikliklerin hemodiyaliz hastalarında önemli olabileceğini düşündürmektedir. Bununla birlikte, Cu ve Fe arasındaki korelasyon bu elementler arasında bir ilişkinin olduğunu göstermektedir. Fe ile Cu arasındaki ilişkinin aydınlanması için daha ileri çalışmalara ihtiyaç vardır.Öğe Karoti?nleri?n Vi?tami?n A'ya Dönüşümleri? ve Vi?tami?n A Metaboli?zması I. B-Karoti?ni?n Vi?tami?n A'ya Dönüşüm Mekani?zması (Derleme)(Selçuk Üniversitesi, 1992 Mart) Tiftik, Ali MuhtarAfter vitamin A well recognized and relationships between carotenes and vitamin A were established, two theories have been put regarding the mechanism of conversion of B-carotene invo vitamin A. The purpose of this review is to reflect some short knowlodge arising from the results of these studies.Öğe Klor Anali?zi? I?çi?n Yeni? Bi?r Spektrofotometrik Metot Çalışması(Selçuk Üniversitesi, 1995 Nisan) Tiftik, Ali Muhtar; Kalaycıoğlu, Leyla; Kurtoğlu, FiruzeThe concentrations of the solutions, used in Mohr method (titrimetric method for chloride), were changed and evaluated in the different pathway to obtain new spectrophotometric method for chlorid analyses. The principle of the method is based on two reactions. First, all chlorid precipitate with the silver, and second, the rest of the silver react with chromate ions. After centrifugation, the restness of the chromate in the supernatant of the solution is related to the chloride concentration in the test tubes and chloride concentration is calculated via optic density of the rest of the chromate. Since no chloride added in the reagent blank tube, the differences of the optic density of the chromate in reagent blank and test tubes are related to the chloride concentration directly. In a number observations for analyses of the K?CrO4, it is found that the ideal vawelength is 380 nm.Öğe Köpeklerde Alloksan ile Oluşturulan Eksperi?mental Di?abetes Üzeri?nde Araştırmalar(Selçuk Üniversitesi, 1992 Mart) Tiftik, Ali Muhtar; Turgut, Kürşat; Gürbilek, Mehmet; Sevinç, MutluIn this investigation, nine healthy dogs weighing from 9 to 20 kg were used. The dogs were made diabetic by a single intravenous injection of 0.60-0.70 mmol/kg bw of alloxan. Intravenous glucose tolerance tests (IVGTT) were done at the beginning of the study and in the second weeks of alloxan injections. At the beginning of the study, the mean values of fasted plasma glucose and insulin were found to be 4.56 ± 0.32 mmol/1 and 9.73 ± 2.69 mU/ml respectively. After the alloxan injections, clear hyperglycemia and decreasing insulin levels were determined and plasma insulin levels waried between 0-5.33 mU/ml during the study. In the urinalyses, glucosuria, ketonuria, proteinuria and decreased urinary pH levels were observed in the alloxan diabetic dogs. After diabetes occured, experimental diets (low high fibre diets) periode was started. Increasig plasma glucose levels were determined During the low fibre diet periode whereas decreasing glucose levels determined in the high diet periode. It is concluded that, it is necessary to apply the IVGTT for the certain diagnosis of diabetes and it is appropriate the recommend of rye bread for the regulation of hyperglycemia.Öğe Köpeklerde Alloksanın Bazı Kan Parametreleri? Üzeri?ne Etki?si?(Selçuk Üniversitesi, 1992 Mart) Tiftik, Ali Muhtar; Turgut, Kürşat; Özeren, FiruzeThe effect of alloxan on some blood parameters of six alloxan diabetic dogs was investigated. Alloxan was given to the each dog at the rate of 0.60 mmol/kg and plasma glucose, aspartat amino transferase (AST), total protein (TP), Na and K values were determined in the collected blood samples in the different days before and after alloxan injection. At the begining of the study these values were found to be 4.18 ± 0.22 mmol/l, 13.89 ± 3.19 U?, 43.7 ± 3.09 g/l, 153,40±4.74 mEq/land 4.64±0.6 mEq/l respectively whereas they found as 15.31 ± 1.22 mmol/l, 20.20+ 2.21 U/l, 51.3 ±3.01 g/l, 151.46 ± 11.2 mEq/l and 4.08 ± 0.43 mEq/l at the end of the study respectively. Only the differences of glucose values were statistically significant (P < 0.01) in the analysed parameters.Öğe Köpeklerde Bazı Trankilizanların Kan ve Serebrospinal Sıvıdaki Çeşitli Biyokimyasal Değerler Üzerine Etkilerinin Araştırılması(Selçuk Üniversitesi, 1990 Ocak) İzci, Celal; Yavru, Nuri; Tiftik, Ali Muhtar; Koç, YılmazThis study was carried out in three groups, that each group consists of 5 dogs. In the first group xylazine, in the second group propionylprozmazine and third group promazine was used intravenously, as a doses of mg per kg body weight 3.5, 0.3 and 3 mg respectively. In all the animals blood an cerebrospinal fluid samples were taken first before and then after the application of drug on 30th, 60th and 120th minutes. In the samples changes in glucose, sodium, potassium, calcium and phosphor parameters were investigated.Öğe Koyunlarda Experimental Olarak Meydana Geti?ri?len Ketosi?zte Kan Metaboli?tleri?, Rumen Protozoonları I?nsuli?n Düzeyi? ve Karaci?ger Yağlanması ile Ni?asi?n in Bu Parametrelere Etki?si?(Selçuk Üniversitesi, 1988 Ocak) Aslan, Veysi; Aştı, Reşat; Tiftik, Ali Muhtar; Eksen, MürsayettinIn this investigation, phlorizin was used to induce ketosis in Akkaraman ewes. Before the experiment, all ewes were examined clinically. After the blood was obtained from jugular vein and SGOT, serum insulin levels, blood sugar and total protein concentrations, Na, K levels, Hb and PCV, total leucocyte and differential leucocyte separations were counted. These parameters were accepted as a normal values. phlorizin was injected twice daily to each animal for a period of 12 days. Clinical and blood examinations ofewes were controlled on the 1st, 3th, 6th, 9th days after injection of phlorizin. At the end of phlorizin injection to sheep, rumen content and liver biopsi materials were obtained. Normal SGOT, serum insulin, blood sugar, total protein concentrations, Na, K levels, Hb and PCV, total leucocyte count were found to be as 48.2 U/L, 22.53 mIU/ml, 65.1 mg/dl, 5.86 gr/ dl, 138.4 mEq/L, 16 mEq/L, 6.08 % mg, 28 %, 10.6 x 101 respectively. These parameters have been changed at the end of phlorizin injection (on the 12 day) as 105.72 U/L, 4.52 mIU/ml, 32.3 mg/dl, 6.6 gr/ dl, 315.8 mEq/L, 17 mEq/L, 5.24 % mg, 28 %, 13.9 × 103 respectively and total rumen protozoa count decreased to 20.2004852/ ml and diffuse lipit infiltrastion was seen in epithelial cells of liver. On the 12 the day of the experiment, niacin was given orally to the animals for five days. At the end of the treatment, blood sugar incerased to 60.6 mg/dl, serum insulin levels increased to 20.46 mIU/ml, SGOT decreased to 55.4 U/L, rumen protozoa count increased to 111400 + 15883/ ml and lipid drops in liver samples were disappeared. The other blood parameters have also been changed and all animals were recovered by this treatment.Öğe Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation(WILEY, 2007) Öztekin, Esma; Tiftik, Ali Muhtar; Baltacı, Abdülkerim Kasım; Moğulkoç, RasimThe present study aimed to determine the effect of estradiol-progesterone supplementation and pinealectomy on lipid peroxidation of liver tissue in ovariectomized rats. The study was carried out on 36 adult Sprague-Dawley female rats, which weighed 200-250 g. The rats were divided into 6 groups: Group 1: Sham Ovariectomy (Sham-Ovx), Group 2: Ovariectomy (Ovx), Group 3: Ovx + Estradiol-Progesterone supplementation (Ovx + H), Group 4: Sham Pinealectomy and Ovx (Sham Pnx -Ovx), Group 5: Ovx -Pnx, Group 6: Ovx -Pnx + H. Malondialdehyde (MDA), reduced form of glutathione (GSH) and glutathione peroxidase (GSH-Px) levels were determined in liver tissue of rats. The highest MDA levels and the lowest GSH-Px levels were determined in the ovariectomized-pinealectomized group, whereas the lowest MDA was in the Sham-Ovx group, and the highest GSH-Px levels were found in the Sham-Ovx and Ovx + Hormone supplemented group. Furthermore, the highest GSH levels were in group 1 and lowest levels were in group 5. The findings of this study demonstrate that ovariectomy led to lipid peroxidation in liver tissues of rats. Pinealectomy in addition to ovariectomy, increases lipid peroxidation, but, estradiol and progesterone supplementations to the ovariectomized-pinealectomized rats protect against lipid peroxidation to a significant extent. Copyright (C) 2006 John Wiley & Sons, Ltd.Öğe Lipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementation(WILEY, 2007) Öztekin, Esma; Baltacı, Abdülkerim Kasım; Tiftik, Ali Muhtar; Moğulkoç, RasimIn the present study, we investigated the effect of estradiol and progesterone supplementation on oxidant and antioxidant parameters of renal tissue in ovariectomized and pinealectomized rats. The study was carried out on 36 adult, Spraque-Dawley strain female rats, 6 months of age and weighing 200-250g. The rats were divided into six groups, each group included six rats: Group 1: Sham-ovariectomized (Sham-Ovx) Group 2: Ovariectomized (Ovx) Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) Group 4: Ovariectomized and sham pinealectomy (Ovx+sham Pnx) Group 5: Ovariectomized+Pinealectomized (Ovx+Pnx) Group 6: Ovariectomized+Pinealectomized+Hormone Supplemented group (Ovx+Pnx+E-P) The levels of malondialdehyde (NIDA), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) were analysed in renal tissues of rats. The highest and the lowest levels of MDA were determined in Groups 5 and 1 respectively (p < 0.001). However, GSH and GSH-Px levels demonstrated statistically important decreases in groups 2, 4, 5 (p < 0.001). The findings of this study demonstrate that ovariectomy leads to oxidative damage in renal tissue. Pinealectomy in addition to ovariectomy greatly increases the oxidative damage. However, female sex hormones supplementations to the Ovx and/or Ovx+Pnx rats protected against lipid peroxidation by activating the antioxidant system. Copyright (c) 2006 John Wiley & Sons, Ltd.Öğe Observed changes in some biochemical parameters after magnetic field exposure to 1,5 tesla(2012) Akdağ, Turan; Tiftik, Ali Muhtar; Sarıyıldız, LeventAmaç: Günlük yaşamda bireyler farklı kaynaklardan değişik düzeylerde elektromanyetik kirlenmeye maruz kalmaktadırlar. Manyetik Rezonans Görüntüleme (MRG), radyofrekans dalgalarını kullanan radyodiagnostik görüntüleme yöntemi olup bireyler uygulama boyunca manyetik alana maruz kalmaktadırlar. Olası olumsuz etkilerin ancak uzun vadede ortaya çıkabileceği düşünüldüğünde komplikasyonların önceden belirlenmesi oldukça önem-lidir. Bu nedenle MRG’nin bazı biyokimyasal değerlere etkisi çalışmada or-taya konulmaya çalışılmıştır. Gereç ve Yöntem: Çalışmaya MRG çekimi için başvuran ve herhangi bir sistemik hastalığı olmayan, 25- 45 yaşları arasında gönüllü toplam 40 birey alındı. Kan örnekleri MRG uygulama öncesi ve sonrası olmak üzere 2 kez çalışıldı. MRG uygulamasına alınan bireyler istenen tet-kik gereği 1,5 T’lık manyetik alana 30 dakika süresince maruz kaldılar. Kan örnekleri bekletilmeden santrifüj edilerek otoanalizörde; glukoz, Ca, koles-terol, trigliserid, HDL, LDL, Fe, Fe bağlama, lipaz, TT3, TT4, free T3, free T4, TSH, insülin ve ferritin değerleri incelendi. Bulgular: Çalışmada MRG uygula-ma sonrası ölçülen Ca, kolesterol, trigliserid, HDL, TT3, Fe, Fe bağlama, lipaz, TSH, insülin değerlerinin uygulama öncesine göre düştüğü ve değişimin ista-tiksel olarak anlamlı olduğu ortaya konulmuştur (P0.05). LDL, glukoz, fer-ritin, free T3, free T4 ve Total T4’te ortaya çıkan değişikliklerin ise istatiksel olarak anlamlı olmadığı görülmektedir. Sonuç: Meydana gelen değişikliklerin geçici olup olmadığının saptanması ve biyolojik etkisinin boyutuna ilişkin çıkarımlar için ileri çalışmalara gereksinim vardır.
