Lipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementation
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, we investigated the effect of estradiol and progesterone supplementation on oxidant and antioxidant parameters of renal tissue in ovariectomized and pinealectomized rats. The study was carried out on 36 adult, Spraque-Dawley strain female rats, 6 months of age and weighing 200-250g. The rats were divided into six groups, each group included six rats: Group 1: Sham-ovariectomized (Sham-Ovx) Group 2: Ovariectomized (Ovx) Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) Group 4: Ovariectomized and sham pinealectomy (Ovx+sham Pnx) Group 5: Ovariectomized+Pinealectomized (Ovx+Pnx) Group 6: Ovariectomized+Pinealectomized+Hormone Supplemented group (Ovx+Pnx+E-P) The levels of malondialdehyde (NIDA), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) were analysed in renal tissues of rats. The highest and the lowest levels of MDA were determined in Groups 5 and 1 respectively (p < 0.001). However, GSH and GSH-Px levels demonstrated statistically important decreases in groups 2, 4, 5 (p < 0.001). The findings of this study demonstrate that ovariectomy leads to oxidative damage in renal tissue. Pinealectomy in addition to ovariectomy greatly increases the oxidative damage. However, female sex hormones supplementations to the Ovx and/or Ovx+Pnx rats protected against lipid peroxidation by activating the antioxidant system. Copyright (c) 2006 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
ovariectomy, pinealectomy, estrogen, progesterone supplementation, renal tissue
Kaynak
CELL BIOCHEMISTRY AND FUNCTION
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
25
Sayı
5
