Lipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementation

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dc.contributor.authorÖztekin, Esma
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorTiftik, Ali Muhtar
dc.contributor.authorMoğulkoç, Rasim
dc.date.accessioned2020-03-26T17:17:38Z
dc.date.available2020-03-26T17:17:38Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, we investigated the effect of estradiol and progesterone supplementation on oxidant and antioxidant parameters of renal tissue in ovariectomized and pinealectomized rats. The study was carried out on 36 adult, Spraque-Dawley strain female rats, 6 months of age and weighing 200-250g. The rats were divided into six groups, each group included six rats: Group 1: Sham-ovariectomized (Sham-Ovx) Group 2: Ovariectomized (Ovx) Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) Group 4: Ovariectomized and sham pinealectomy (Ovx+sham Pnx) Group 5: Ovariectomized+Pinealectomized (Ovx+Pnx) Group 6: Ovariectomized+Pinealectomized+Hormone Supplemented group (Ovx+Pnx+E-P) The levels of malondialdehyde (NIDA), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) were analysed in renal tissues of rats. The highest and the lowest levels of MDA were determined in Groups 5 and 1 respectively (p < 0.001). However, GSH and GSH-Px levels demonstrated statistically important decreases in groups 2, 4, 5 (p < 0.001). The findings of this study demonstrate that ovariectomy leads to oxidative damage in renal tissue. Pinealectomy in addition to ovariectomy greatly increases the oxidative damage. However, female sex hormones supplementations to the Ovx and/or Ovx+Pnx rats protected against lipid peroxidation by activating the antioxidant system. Copyright (c) 2006 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1360en_US
dc.identifier.endpage554en_US
dc.identifier.issn0263-6484en_US
dc.identifier.issn1099-0844en_US
dc.identifier.issue5en_US
dc.identifier.pmid16892453en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage551en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.1360
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21460
dc.identifier.volume25en_US
dc.identifier.wosWOS:000249634900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofCELL BIOCHEMISTRY AND FUNCTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariectomyen_US
dc.subjectpinealectomyen_US
dc.subjectestrogenen_US
dc.subjectprogesterone supplementationen_US
dc.subjectrenal tissueen_US
dc.titleLipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementationen_US
dc.typeArticleen_US

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