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Öğe Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Gergerlioglu, H. Serdar; Savas, Haluk A.; Bulbul, Feridun; Selek, Salih; Uz, Efkan; Yumru, MehmetOxidant nitric oxide (NO) and antioxidant superoxide dismutase (SOD) have been implicated to play a role in the pathogenesis of bipolar disorders. This is the first prospective study aimed to evaluate NO levels and SOD activity in bipolar disorder (type I manic episode) (BD-ME). 29 inpatient subjects with BD-ME and 30 healthy controls were included. Serum NO levels and SOD activity have been studied at 1st (NO [1st] and SOD [1st] respectively) and 30th days (NO [30th] and SOD [30th] respectively) after treatment. The clinical outcome was measured by Bech-Rafaelson Mania Scale (BRMS). The mean NO [1st] (p <.001) and NO [30th] levels (p <.00 1) were higher than controls, but SOD [ I st] (p <.001) and SOD [30th] (p <.001) activities in BD-ME were lower than controls. SOD1 activity was higher than SOD [30th] (p <.001), while there was no significance in comparison between NO [1st] and NO [30th] (p <.05). SOD [30th] activity is negatively correlated with the number of previous manic attacks and NO [1st] was negatively correlated with sleep item score of BRMS at first day. Also there was a significant correlation between NO [1st] levels and with the existence of a delusion. NO and SOD appear to play a role in the pathophysiological events occurring in BD, especially in BD-ME. This study for the first time showed the possible role of NO on sleep and the generation of delusions in the pathophysiology of BD. In the light of literature, induced glutamate pathway might be responsible for delusions in BD. The results of this research need further investigation to understand the oxidative vs antioxidative process in BD. (c) 2007 Elsevier Inc. All rights reserved.Öğe Changes in nitric oxide level and superoxide dismutase activity during antimanic treatment (vol 31, pg 697, 2007)(PERGAMON-ELSEVIER SCIENCE LTD, 2007) Gergerlioglu, H. Serdar; Savas, Haluk A.; Bulbul, Feridun; Selek, Salih; Uz, Efkan; Yumru, Mehmet[Abstract not Available]Öğe Correlation Between Metabolic Syndrome and Serum Ghrelin Levels in Bipolar Patients(AVES, 2010) Kalenderoğlu, Aysun; Savaş, Haluk A.; Gergerlioğlu, H. Serdar; Başaralı, Kemal; Yumru, Mehmet; Selek, Salih; Büyükbaş, Sadık; Ergene, NeyhanAmaç: Bu araştırmada ikiuçlu bozukluk hastalarında serum ghrelin düzeyleri ve Metabolik Sendrom (MetS) arasında bir ilişkinin olup olmadığının incelenmesi amaçlanmıştır. Yöntemler: Altmış ikiuçlu bozukluk hastası ve 30 sağlıklı gönüllü çalışmaya da- hil edildi. Hasta grubu atipik antipsikotik (risperidon, ketiapin, olanzapin) ve duy- gudurum düzenleyici (lityum, valproik asit, karbamazepin, lamotrijin) kullanımı- na göre iki ayrı gruba ayrıldı. Serum ghrelin seviyeleri insan ghrelin ELISA kitle- ri aracılığıyla ölçüldü. Hasta grubunda, NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) ölçütlerine göre MetS tanısı aşağıdakilerden 3 ya da daha fazlasının karşılanması ile değerlendirilmiştir. Bulgular: Çalışmaya alınan bipolar hastaların %51.7'si (n=31) sadece atipik an- tipsikotik (AA) tedavisi alırken, %48.8'ü (=29) sadece duygudurum düzenleyeci- si (DD) kullanıyordu. Hasta grubunda %36.7 (n=22) hastaya MetS tanısı konul- muştur. Hasta grubunda MetS olan ve olmayanlar arasında ghrelin düzeyleri açısından anlamlı fark yoktu. İlaveten AA kullanan ve MetS gelişen hastalarda ghrelin düzeyleri açısından anlamlı fark yoktu. DD kullanan ve Mets geliştirmiş olan hastalarda ghrelin düzeyleri açısından anlamlı fark yoktu. Serum ghrelin seviyeleri kontrol grubu ile kıyaslandığında bipolar hastalarda anlamlı oranda düşük bulunmuştur. Sonuç: Çalışmamızda ikiuçlu bozukluk hastalarında genel populasyona oranla daha fazla oranda MetS görülmüştür. Serum ghrelin seviyeleri bipolar hastalar- da anlamlı düzeyde düşük bulundu. Bu sonucun kompansatuar bir mekanizma ile ilişkili olabileceği ya da hastalığı özgü farklı parametrelerin rol alabileceği düşünüldü.Öğe The course of nitric oxide and superoxide dismutase during treatment of bipolar depressive episode(ELSEVIER SCIENCE BV, 2008) Selek, Salih; Savas, Haluk A.; Gergerlioglu, H. Serdar; Bulbul, Feridun; Uz, Efkan; Yumru, MehmetBackground and aims: Studies have already pointed out a possible pathophysiological role of oxidative and antioxidative molecules in bipolar disorder. We aimed to evaluate the activity and levels of antioxidant superoxide dismutase (SOD), and oxidant nitric oxide (NO), in bipolar I depressive episode (BD-DE) patients in a prospective design. Method: 30 BD-DE patients, diagnosed according to DSM IV, and 30 healthy volunteer controls were included. The serum levels of NO and SOD have been studied when admitted to hospital (1st) and on the 30th days. Clinical outcome was measured by Hamilton Depression Scale (HAM-D). The patients were allowed to have their treatments. One patient was dropped out due to insufficient sampling. Results: As in the previous studies, NO 1st day levels were significantly higher in patients and SOD 1st day activity was significantly low (p < 0.0 1). NO levels significantly decreased (p < 0.0 1) and normalized, as SOD activity significantly increased but did not reach to the controls' levels (p < 0.01) on the 30th day. Conclusion: Despite normalized NO levels, persistent low SOD activity might point out an oxidative imbalance in BD-DE. Chronic low SOD activity may be associated with incapacity of coping with oxidative stress. This research connotes the probable oxidative imbalance in BD-DE and discusses that phenomenon within the continuum of the disease state. (C) 2007 Elsevier B.V. All rights reserved.Öğe İkiuçlu bozuklukta metabolik sendrom, serum leptin düzeyleri ve tedavi ilişkisi(2008) Yumru, Mehmet; Savaş, Esen; Gergerlioğlu, H.Serdar; Başaralı, Kemal; Kalenderoğlu, Aysun; Savaş, Haluk A.; Büyükbaş, SadıkAmaç: Bu çalışmada ikiuçlu bozuklukta metabolik sendrom, serum leptin seviyeleri ve tedavi arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Yöntem: En az 3 ay süre ile atipik antipsikotik (AA) (risperidon, ketiapin, olanzapin) almış 31 ve duygudurum düzenleyici (DD) (lityum, valproik asit, karbamazepin, lamotrijin) almış 29 hasta olmak üzere ikiuçlu bozukluk I tanısı konan ötimik dönemdeki toplam 60 hasta çalışmaya alındı. Metabolik Sendrom (MetS) NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Program) ölçütlerine göre tarandı. Bulgular: Hastaların %36.7’sinde MetS görüldü. AA alt grubunda DD alt grubuna oranla daha yüksek oranda MetS görüldü. Abdominal obesite ikiuçlu bozuklukta leptin seviyeleri ile anlamlı düzeyde ilişkili olarak saptandı. İkiuçlu bozuklukta leptin seviyeleri ve MetS arasında anlamlı bir ilişki bulunamadı. Tartışma: AA kullanan ikiuçlu hastalar yüksek MetS oranlarına sahipti. Bununla birlikte AA’ler arasında MetS sıklığı açısından anlamlı farklılık yoktu. Leptin seviyeleri ikiuçlu hastalarda abdominal obesite ile anlamlı düzeyde ilişkili olmasına karşın MetS ile ilişkili görünmemektedirÖğe The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder(KURE ILETISIM GRUBU A S, 2008) Yumru, Mehmet; Savas, Esen; Gergerlioglu, H. Serdar; Basarali, Kemal; Kalenderoglu, Aysun; Savas, Haluk A.; Bueyuekbas, SadikObjective: In this study we aimed to evaluate the relationship between serum leptin. levels, metabolic syndrome and treatment in bipolar patients. Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine) treatment, 31 patients were on atypical antipsychotics (AA) (risperidone, quetiapine, and olanzapine) for at least 3 months. Metabolic syndrome (MetS) was evaluated according to NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education Programme) criteria. Results: 36.7% of the patients were recognized as MetS. The AA subgroup had significantly more MetS than MS. Abdominal obesity was significantly correlated with leptin levels in BD. No significant association was found between MetS and leptin levels in BD. Discussion: AA taking bipolar patients had higher MetS rates. However, there was no significant difference among AAs for inducing MetS. Leptin levels were significantly correlated with abdominal obesity in bipolar patients but seem not to be associated with MetS.
