Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum

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dc.contributor.authorKarakurt, Serdar
dc.contributor.authorSemiz, Aslı
dc.contributor.authorÇelik, Gurbet
dc.contributor.authorÖzkan, Ayşe Mine Gençler
dc.contributor.authorŞen, Alaattin
dc.contributor.authorAdalı, Orhan
dc.date.accessioned2020-03-26T19:23:27Z
dc.date.available2020-03-26T19:23:27Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the present study, the possible role of ellagic acid (EA) on antioxidant potential of Epilobium hirsutum (EH) in rat liver was investigated. Wistar rats were intraperitoneally treated with 37.5 mg/kg of EH and 10 mg/kg of EA for 9 days. Effects of EH and EA on antioxidant [glutathione peroxidase (GPx) and superoxide dismutases (SOD)] and Phase II [NADPH quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTs)] enzyme activities, as well as protein and mRNA expressions of those, were investigated. Polyphenolic content of EH was determined by LC-MS/MS analysis. EH and EA injection to rats resulted in a significant increase of NQO1 (3.6-fold and 4.7-fold), GPx (1.45-fold), and SOD (1.34-fold and 1.27-fold) enzyme activities, whereas total GST (46% and 57%) and its isoforms, and GST mu (57% and 72%), and GST theta (60% and 68%) activities were significantly decreased. Western-blot and qRT-PCR analysis showed that NQO1 and GPx protein and mRNA expressions were increased significantly (P < 0.0001), whereas GST mu and GST theta were significantly decreased (P < 0.0001).en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109R012]en_US
dc.description.sponsorshipThis work is supported by TUBITAK (Project Number: 109R012).en_US
dc.identifier.doi10.1080/01635581.2016.1115092en_US
dc.identifier.endpage183en_US
dc.identifier.issn0163-5581en_US
dc.identifier.issn1532-7914en_US
dc.identifier.issue1en_US
dc.identifier.pmid26700224en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://dx.doi.org/10.1080/01635581.2016.1115092
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33399
dc.identifier.volume68en_US
dc.identifier.wosWOS:000374779500019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNUTRITION AND CANCER-AN INTERNATIONAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleContribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutumen_US
dc.typeArticleen_US

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