Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes

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dc.contributor.authorAy, Emre
dc.contributor.authorMarakoglu, Kamile
dc.contributor.authorKizmaz, Muhammet
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T19:24:06Z
dc.date.available2020-03-26T19:24:06Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackgroundNetrin-1 is a diagnostic biomarker that has been identified recently for chronic renal failure (CRF) in animal experiments. Netrin-1 levels in urine have been shown to have increased significantly at the acute kidney damage. Human studies on the relation between the CRF and plasma netrin-1 levels have not been found in the literature. This study aimed to investigate whether plasma netrin-1 levels increased in the early stages of the CRF in diabetic patients. MethodsPlasma samples from healthy volunteers and diabetic patients with and without microalbuminuria were collected after receiving consent. Netrin-1 in plasma was quantified by enzyme-linked immunosorbent assay and the data were analyzed to determine whether plasma netrin-1 correlates significantly with disease progression. ResultPlasma netrin-1 level in microalbuminuric diabetic patients was significantly higher than in normoalbuminuric diabetic patients and the control group. However, no significant difference between normoalbuminuric patients and control group was determined. Plasma netrin-1 level was significantly associated with albuminuria and estimated glomerular filtration rate, independently of age and sex. ConclusionThis study supports that plasma netrin-1 level increases significantly when glomerular damage occurs in diabetic nephropathy.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [14102047]en_US
dc.description.sponsorshipThis study was supported by Selcuk University, Scientific Research Projects (Project Number: 14102047).en_US
dc.identifier.doi10.1002/jcla.21965en_US
dc.identifier.endpage977en_US
dc.identifier.issn0887-8013en_US
dc.identifier.issn1098-2825en_US
dc.identifier.issue6en_US
dc.identifier.pmid27076403en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage972en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jcla.21965
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33577
dc.identifier.volume30en_US
dc.identifier.wosWOS:000386935200027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJOHN WILEY & SONS INCen_US
dc.relation.ispartofJOURNAL OF CLINICAL LABORATORY ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectnetrin-1en_US
dc.subjectalbuminuriaen_US
dc.subjectdiabetic nephropathyen_US
dc.titleEvaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetesen_US
dc.typeArticleen_US

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