Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent

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dc.contributor.authorCampestre, Cristina
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorGuglielmi, Paolo
dc.contributor.authorDe Luca, Elisa
dc.contributor.authorBellagamba, Giuseppe
dc.contributor.authorMenta, Sergio
dc.contributor.authorZengin, Gökhan
dc.date.accessioned2020-03-26T19:33:50Z
dc.date.available2020-03-26T19:33:50Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThis paper reports the MEPS-HPLC-DAD method for the simultaneous determination of 12 azole drugs (bifonazole, butoconazole, clotrimazole, econazole, itraconazole, ketoconazole, miconazole, posaconazole, ravuconazole, terconazole, tioconazole and voriconazole) administered to treat different systemic and topical fungal infections, in biological samples. Azole drugs separation was performed in 36 min. The analytical method was validated in the ranges as follows: 0.02-5 mu g mL(-1) for ravuconazole; 0.2-5 mu g mL(-1) for terconazole; 0.05-5 mu g mL(-1) for the other compounds. Human plasma and urine were used as biological samples during the analysis, while benzyl-4-hydroxybenzoate was used as an internal standard. The precision (RSD%) and trueness (Bias%) values fulfill with International Guidelines requirements. To the best of our knowledge, this is the first HPLC-DAD procedure coupled to MEPS, which provides the simultaneous analysis of 12 azole drugs, available in the market, in human plasma and urine. Moreover, the method was successfully applied for the quantitative determination of two model drugs (itraconazole and miconazole) after oral administration in real samples.en_US
dc.description.sponsorshipMIUR FAR, University of Chieti - Pescara "G. d'Annunzio", Chieti, Italyen_US
dc.description.sponsorshipThis work was supported by MIUR FAR (ex 60%), University of Chieti - Pescara "G. d'Annunzio", Chieti, Italy.en_US
dc.identifier.doi10.1080/14756366.2017.1354858en_US
dc.identifier.endpage1063en_US
dc.identifier.issn1475-6366en_US
dc.identifier.issn1475-6374en_US
dc.identifier.issue1en_US
dc.identifier.pmid28776447en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1053en_US
dc.identifier.urihttps://dx.doi.org/10.1080/14756366.2017.1354858
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34795
dc.identifier.volume32en_US
dc.identifier.wosWOS:000416951100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMEPS-HPLC-DADen_US
dc.subjectmethod developmenten_US
dc.subjectplasma and urineen_US
dc.subjectsample preparationen_US
dc.subjectazole antifungal drugsen_US
dc.titleAnalysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbenten_US
dc.typeArticleen_US

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