Tezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Rats

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dc.contributor.authorGulmen, Senol
dc.contributor.authorKiris, Ilker
dc.contributor.authorNarin, Cuneyt
dc.contributor.authorCeylan, Berit Gokce
dc.contributor.authorMermi, Betul
dc.contributor.authorSutcu, Recep
dc.contributor.authorMeteoglu, Ibrahim
dc.date.accessioned2020-03-26T17:40:27Z
dc.date.available2020-03-26T17:40:27Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground. Renal injury induced by aortic ischemia-reperfusion (IR) is an important factor in the development of postoperative acute renal failure following abdominal aortic surgery. Endothelin (ET) is involved in the development of renal injury induced by aortic IR and tezosentan (R0 61-0612) is a specific ET receptor antagonist. The aim of this study was to examine the effect of tezosentan on renal injury induced by abdominal aortic IR in rats. Material and Methods. Twenty-four Wistar-Albino rats were randomized into three groups (eight per group). Control group underwent laparotomy and dissection of the infrarenal abdominal aorta (IAA) without occlusion. The aortic IR group underwent laparotomy and clamping of the IAA for 120 min followed by 120 min of reperfusion. Aortic IR + tezosentan group underwent same aortic IR periods, and received a bolus intravenous injection of 10 mg/kg tezosentan before ischemia plus continuous intravenous infusion of 1 mg/kg/h tezosentan during 120 min ischemia and 120 min reperfusion. At the end of the experiment, blood and kidney tissue specimens were obtained for biochemical analysis. Histological evaluation of the rat kidney tissues was also done. Results. Biochemical analysis showed that aortic IR significantly increased (P<0.05 versus control) while tezosentan significantly decreased (P<0.05 versus aortic IR) the tissue levels of malondialdehyde, superoxide dismutase, catalase and myeloperoxidase. Histological analyses showed that aortic IR significantly increased (P<0.05 versus control) while tezosentan significantly decreased (P<0.05 versus aortic IR) focal glomerular necrosis, dilatation of Bowman's capsule, degeneration of tubular epithelium, necrosis in tubular epithelium and tubular dilatation in the renal tissue samples. Conclusion. The results of this study indicate that tezosentan reduces renal injury induced by aortic IR in rats. We think that tezosentan exerted this beneficial effect via reducing oxidative stress and lipid peroxidation, inhibition of leukocyte infiltration into renal tissue and acting cytoprotective on renal tubular cells after aortic IR. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2008.08.011en_US
dc.identifier.endpageE13en_US
dc.identifier.issn0022-4804en_US
dc.identifier.issn1095-8673en_US
dc.identifier.issue1en_US
dc.identifier.pmid19329125en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE7en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2008.08.011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23907
dc.identifier.volume157en_US
dc.identifier.wosWOS:000207944900002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttezosentanen_US
dc.subjectrenal injuryen_US
dc.subjectabdominal aortaen_US
dc.subjectischemia-reperfusionen_US
dc.titleTezosentan Reduces the Renal Injury Induced by Abdominal Aortic Ischemia-Reperfusion in Ratsen_US
dc.typeArticleen_US

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