The effect of N-acetyl cysteine on serum glutathione, TNF-alpha and tissue malondialdehyde levels in the treatment of sepsis

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dc.contributor.authorGul, Mehmet
dc.contributor.authorAyan, Murat
dc.contributor.authorSeydanoglu, Abdusselam
dc.contributor.authorCander, Basar
dc.contributor.authorGirisgin, Sadik
dc.contributor.authorErayman, Ibrahim
dc.contributor.authorErdem, Sami
dc.date.accessioned2020-03-26T18:16:40Z
dc.date.available2020-03-26T18:16:40Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBACKGROUND The aim of this study was to investigate the effects of N-acetyl cysteine (NAC) on the levels of reactive oxygen species in sepsis. METHODS In this study, 30 Sprague-Dawley female rats weighing 180-200 g were used. Rats were randomized into three groups, each containing 10 rats, as follows: Group I: Sham, Group II: Sepsis and Group III: Sepsis+NAC. Group I underwent only laparotomy. In Groups II and III, sepsis was induced by cecal ligation and perforation (CLP) technique. NAC (20 mg/kg/day) was administered orally to Group III at 0, 8 and 16 hours. At the 24th hour, tissue and blood samples were taken for erythrocyte glutathione (GSH) and serum tumor necrosis factor (TNF)-alpha levels, histopathological determination, and lung, liver and kidney tissue malondialdehyde (MDA) analyses. RESULTS Group III was significantly different from the other groups with respect to erythrocyte glutathione, serum TNF-alpha and kidney MDA levels (p<0.05). There was no significant difference between the groups regarding liver MDA levels and histopathological parameters for lung, liver and kidney (p>0.05). CONCLUSION NAC treatment had beneficial effects on erythrocyte GSH, serum TNF-alpha, lung function, and kidney MDA levels in sepsis-induced rats. However, this beneficial effect was not confirmed as histopathological improvement. Further research is needed to prove the effect of NAC in sepsis treatment.en_US
dc.identifier.doi10.5505/tjtes.2011.66743en_US
dc.identifier.endpage297en_US
dc.identifier.issn1306-696Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid21935824en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage293en_US
dc.identifier.urihttps://dx.doi.org/10.5505/tjtes.2011.66743
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26908
dc.identifier.volume17en_US
dc.identifier.wosWOS:000294350400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH ASSOC TRAUMA EMERGENCY SURGERYen_US
dc.relation.ispartofULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlutathioneen_US
dc.subjectN-acetyl cysteineen_US
dc.subjectsepsisen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.subjectmalondialdehydeen_US
dc.titleThe effect of N-acetyl cysteine on serum glutathione, TNF-alpha and tissue malondialdehyde levels in the treatment of sepsisen_US
dc.typeArticleen_US

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