Vapocoolant Spray vs Lidocaine/Prilocaine Cream for Reducing the Pain of Venipuncture in Hemodialysis Patients: A Randomized, Placebo-Controlled, Crossover Study

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dc.contributor.authorCelik, Gulperi
dc.contributor.authorOzbek, Orhan
dc.contributor.authorYilmaz, Mumtaz
dc.contributor.authorDuman, Ipek
dc.contributor.authorOzbek, Seda
dc.contributor.authorApiliogullari, Seza
dc.date.accessioned2020-03-26T18:17:30Z
dc.date.available2020-03-26T18:17:30Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Patients undergoing hemodialysis are repeatedly exposed to stress and pain from approximately 300 punctures per year to their arteriovenous fistula. This study was designed to measure pain associated with venepuncture during AVF cannulation and to compare the effectiveness of ethyl chloride vapocoolant spray, topical eutectic mixture of local anesthetics (EMLA) cream and placebo in controlling pain caused by venepuncture of arteriovenous fistula patients undergoing chronic hemodialysis. Methods: This randomized, placebo-controlled, crossover study, included 41 patients undergoing conventional hemodialysis three times a week. First intervention was conducted as baseline pain assessment (control). In the three consecutive dialysis sessions, every patient randomly received 1) ethyl chloride vapocoolant spray, 2) EMLA, or 3) placebo cream before venepuncture. Pain perception was recorded by patients immediately after cannulation on a 0-100 mm visual analogue scale (VAS). p<0.05 was considered as significant. Results: VAS scores presented a marked inter-individual variation during venepuncture. EMLA application resulted in significantly lower total pain scores compared to control and all other interventions (p<0.05). No patient experienced severe pain with EMLA or vapocoolant. The patients reported less moderate and severe pain with EMLA, and vapocoolant spray compared to control and placebo interventions. Moderate and severe pain scores were similar between EMLA and vapocoolant spray (p>0.05). Conclusion: Venipuncture for AVF cannulation causes mild to moderate pain in hemodialysis patients. Although local application of EMLA is more effective than in preventing venepuncture pain, ethyl chloride vapocoolant is as effective as EMLA for preventing mild to moderate puncture pain in patients undergoing hemodialysis.en_US
dc.identifier.doi10.7150/ijms.8.623en_US
dc.identifier.endpage627en_US
dc.identifier.issn1449-1907en_US
dc.identifier.issue7en_US
dc.identifier.pmid22022215en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://dx.doi.org/10.7150/ijms.8.623
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27040
dc.identifier.volume8en_US
dc.identifier.wosWOS:000298011800016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIVYSPRING INT PUBLen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHemodialysisen_US
dc.subjectarteriovenous fistulaen_US
dc.subjectvenepuncture painen_US
dc.subjectvapocoolant sprayen_US
dc.subjectvisual analogue scaleen_US
dc.titleVapocoolant Spray vs Lidocaine/Prilocaine Cream for Reducing the Pain of Venipuncture in Hemodialysis Patients: A Randomized, Placebo-Controlled, Crossover Studyen_US
dc.typeArticleen_US

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