Lycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Rats

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dc.contributor.authorHekimoglu, Askin
dc.contributor.authorKurcer, Zehra
dc.contributor.authorAral, Faruk
dc.contributor.authorBaba, Fuesun
dc.contributor.authorSahna, Engin
dc.contributor.authorAtessahin, Ahmet
dc.date.accessioned2020-03-26T17:39:09Z
dc.date.available2020-03-26T17:39:09Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractTesticular torsion is a common syndrome that could lead to infertility. We investigated the therapeutic effects of lycopene, an antioxidant caretenoid, on testicular ischemia/reperfusion (IR) injury that resembles testicular torsion. Male Wistar albino rats were divided into three groups: sham (n = 6), IR (n = 18), and ischemia/reperfusion with lycopene (IRL, n = 18). Left testicular artery and vein was occluded for 1 h, followed by reperfusion of 3 h, 24 h or 30 days in IR and IRL animals. Either corn oil (vehicle) or lycopene (4 mg/kg) was administrated once daily by gavage to IR or IRL animals, respectively, 5 min after ischemia. Sham-operated animals were treated with vehicle by gavage 5 min after the operation. IR decreased sperm motility and concentration in both ipsilateral and contralateral testes and increased abnormal sperm rate in ipsilateral testis after 30 days of reperfusion. Treatment with lycopene increased the motility in bilateral testes and decreased the rate of abnormal sperm in ipsilateral testis to the sham level, but did not increase sperm concentration in bilateral testes. IR increased the activities of catalase and glutathione peroxidase and the level of reduced glutathione by 24 h of reperfusion, but malondialdehyde remained unchanged. Lycopene treatment restored the enzyme activities but not the reduced glutathione level. Lycopene treatment also ameliorated the IR-induced tissue damage in bilateral testes. In conclusion, the therapeutic antioxidant effect of lycopene on germ cells could serve as a promising intervention to oxidative stress-associated infertility problems, such as testicular torsion.en_US
dc.identifier.doi10.1620/tjem.218.141en_US
dc.identifier.endpage147en_US
dc.identifier.issn0040-8727en_US
dc.identifier.issn1349-3329en_US
dc.identifier.issue2en_US
dc.identifier.pmid19478470en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://dx.doi.org/10.1620/tjem.218.141
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23659
dc.identifier.volume218en_US
dc.identifier.wosWOS:000266836800008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTOHOKU UNIV MEDICAL PRESSen_US
dc.relation.ispartofTOHOKU JOURNAL OF EXPERIMENTAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectLycopeneen_US
dc.subjectTestisen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectCatalaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.titleLycopene, an Antioxidant Carotenoid, Attenuates Testicular Injury Caused by Ischemia/Reperfusion in Ratsen_US
dc.typeArticleen_US

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