Frequency of chromosome 17 aneuploidy in primary and recurrent pterygium by interphase-fluorescence in situ hybridization

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dc.contributor.authorKamış, Ümit
dc.contributor.authorKerimoğlu, Hürkan
dc.contributor.authorÖzkağnıcı, Ahmet
dc.contributor.authorAcar, Hasan
dc.date.accessioned2020-03-26T17:03:36Z
dc.date.available2020-03-26T17:03:36Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To investigate chromosome 17 numerical aberrations by using fluorescence in situ hybridization ( FISH) in pterygia and to find out whether there is any association between chromosome 17 aneuploidy and recurrent pterygia. Methods: Pterygium tissue samples were taken from 21 patients by surgical excision. Eighteen of them had primary and 3 had recurrent pterygium. Peripheral whole blood interphase cells obtained from 11 healthy subjects were assigned as control group. The cells from pterygium tissue and peripheral blood were incubated with a hypotonic solution and fixed in order to obtain interphase nuclei. FISH analysis with chromosome-17-specific alpha-satellite DNA probe was performed on both the interphase nuclei of pterygium tissue ( of patients) and peripheral whole blood cells of controls. Results: The mean percentage of chromosome 17 aneuploidy was 4.71% for the pterygia group and 4.41% for the controls. No significant difference of chromosome 17 aneuploidy was observed between the patients and the controls. When the group of patients with recurrences was compared with the group without recurrences, there was a significant difference in the frequency of chromosome 17 aneuploidy ( U = 17, p = 0.029). Conclusions: Chromosome 17 aneuploidy is probably not an important factor in the formation of pterygium, but it may be related to recurrence. Copyright (C) 2006 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000090329en_US
dc.identifier.endpage94en_US
dc.identifier.issn0030-3747en_US
dc.identifier.issue2en_US
dc.identifier.pmid16357492en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000090329
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20505
dc.identifier.volume38en_US
dc.identifier.wosWOS:000235801600007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofOPHTHALMIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectPterygiumen_US
dc.subjectRecurrent pterygiumen_US
dc.subjectChromosome 17en_US
dc.subjectFISHen_US
dc.subjectAneuploidyen_US
dc.titleFrequency of chromosome 17 aneuploidy in primary and recurrent pterygium by interphase-fluorescence in situ hybridizationen_US
dc.typeArticleen_US

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