Relation Between Abnormalities in Circadian Blood Pressure Rhythm and Target Organ Damage in Normotensives

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dc.contributor.authorSoylu, Ahmet
dc.contributor.authorYazici, Mehmet
dc.contributor.authorDuzenli, Mehmet Akif
dc.contributor.authorTokac, Mehmet
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorGok, Hasan
dc.date.accessioned2020-03-26T17:39:57Z
dc.date.available2020-03-26T17:39:57Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: To determine the individual effect of abnormalities in blood pressure (BP) circadian rhythm (non-dipping status (NDS), increased morning BP (MBP) or increased MBP surge (MBPS)) on target organ damage (TOD) and which of these is more closely related to TOD in normotensives. Methods and Results: The 24-h ambulatory BP monitoring (ABPM) and echocardiography were performed and urinary albumin excretion (UAE) was measured in 47 dipper (28 women, mean age 45.8 +/- 9.3) and 32 non-dipper (25 women, mean age 49.1 +/- 8.3 years) normotensive subjects. The left ventricular mass index (LVMI) was higher in non-dipper group (103.8 +/- 24.1 vs 91.6 +/- 23.5 g/m(2), 12, P=0.03). UAE in non-dipper group was higher, but the difference between the two was not statistically significant (18.9 [10.3, 28.9] vs 14.1 [7.5, 23.8], P=0.11). In multivariate analysis, both LVMI and UAE were affected by NDS and MBP independent of other confounding variables (for LVMI; Coefficient=0.27, P=0.01 and Coeffcient=0.37, P=0.001, respectively, and for UAE; Coefficient=0.27, P=0.02 and Coefficient =0.28, P=0.01, respectively). Conclusions: It may be Postulated that increased night and MBP are the factors that cause TOD, and it seems reasonable to attempt to restore normal diurnal rhythm of the BP even in normotensive Subjects. (Circ J 2009; 73: 899-904)en_US
dc.identifier.doi10.1253/circj.CJ-08-0946en_US
dc.identifier.endpage904en_US
dc.identifier.issn1346-9843en_US
dc.identifier.issn1347-4820en_US
dc.identifier.issue5en_US
dc.identifier.pmid19293531en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage899en_US
dc.identifier.urihttps://dx.doi.org/10.1253/circj.CJ-08-0946
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23819
dc.identifier.volume73en_US
dc.identifier.wosWOS:000265570300019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJAPANESE CIRCULATION SOCen_US
dc.relation.ispartofCIRCULATION JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCircadian blood pressure rhythmen_US
dc.subjectNormotensivesen_US
dc.subjectTarget organ damageen_US
dc.titleRelation Between Abnormalities in Circadian Blood Pressure Rhythm and Target Organ Damage in Normotensivesen_US
dc.typeArticleen_US

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