Morning blood pressure surge is associated with serum gamma-glutamyltransferase activity in essential hypertensive patients

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dc.contributor.authorElsürer, Rengin
dc.contributor.authorAfşar, Barış
dc.date.accessioned2020-03-26T19:06:23Z
dc.date.available2020-03-26T19:06:23Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe phenomenon that blood pressure rises sharply in the morning is called 'Morning Blood Pressure Surge' (MBPS). Serum gammaglutamyltransferase (GGT) is a proinflammatory marker involved in the pathogenesis of cardiovascular diseases. Although both are novel cardiovascular risk factors associated with inflammation and atherosclerosis, the specific relationship between MBPS and serum GGT is unknown. This study investigates the relationship between MBPS and serum GGT activity in essential hypertensive patients. Totally, 320 hypertensive patients were recruited. Mean MBPS was 17.0 +/- 12.9 mm Hg. MBPS was positively correlated with age (r = +0.222, P<0.0001), body mass index (r = +0.132, P = 0.018), GGT (r = +0.271, P<0.0001), daytime augmentation index adjusted for heart rate (AIx@75) (r = +0.140, P = 0.014), 24-h pulse wave velocity (PWV) (r = +0.143, P = 0.014) and daytime PWV (r = +0.158, P = 0.007). From the 25th to 75th quartile of serum GGT, MBPS increased significantly (P-trend < 0.0001). In multivariate linear regression analysis, MBPS was independently associated with age (P = 0.002), dipping status (P<0.0001) and logGGT (P<0.0001). In conclusion, MBPS is independently associated serum GGT activity in essential hypertensive patients. This is the first study in the literature to demonstrate an independent and a dose-response relationship between the two novel cardiovascular risk factors, MBPS and serum GGT, in this patient population.en_US
dc.identifier.doi10.1038/jhh.2014.74en_US
dc.identifier.endpage336en_US
dc.identifier.issn0950-9240en_US
dc.identifier.issn1476-5527en_US
dc.identifier.issue5en_US
dc.identifier.pmid25355010en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://dx.doi.org/10.1038/jhh.2014.74
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32339
dc.identifier.volume29en_US
dc.identifier.wosWOS:000352497300009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofJOURNAL OF HUMAN HYPERTENSIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleMorning blood pressure surge is associated with serum gamma-glutamyltransferase activity in essential hypertensive patientsen_US
dc.typeArticleen_US

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