Essential oils from tropical medicinal herbs and food plants inhibit biofilm formation in vitro and are non-cytotoxic to human cells

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dc.contributor.authorAumeeruddy-Elalfi, Zaahira
dc.contributor.authorIsmael, Ismael Said
dc.contributor.authorHosenally, Muzzammil
dc.contributor.authorZengin, Gökhan
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T19:53:47Z
dc.date.available2020-03-26T19:53:47Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe biofilm inhibition and eradication potential of essential oils (EOs) extracted from six tropical medicinal herbs and food plants [Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), Citrus reticulata (CR), and Cinnamomum zeylanicum (CZ)] were assessed. The mechanism of inhibition was studied via quenching of efflux pump. Cytotoxicity was evaluated using Artemia sauna assay and cell lines [human cervix carcinoma (HeLa), human lung fibroblast (MRC-5), and murine melanoma (B16F10)]. EOs of CH, CR, PA, and PT were found to be prospective antibiofilm agents (IC50 of 0.29, 0.59, 0.22, and 0.11 mg/mL against Staphylococcus epidermidis; 0.39, 0.54, 0.09, and 0.13 mg/mL against Escherichia coli; and 0.54, 0.90, 0.44 and 0.51 mg/mL against Candida albicans for CH, CR, PA, and PT, respectively). The simultaneous actions of the EOs and efflux pump inhibitor impacted on the resistance of the biofilms. LC50 of the EOs ranged from 223 to 583 mg/mL against A. salina. The non-cytotoxic concentration of the EOs varied from 200 to 300 mu g/mL (HeLa and MRC-5), and 150-200 mu g/mL (B16F10). EOs from these tropical medicinal herbs and food plants are useful sources of new antimicrobials with low cytotoxicity which could open new horizons in the drug development process.en_US
dc.identifier.doi10.1007/s13205-018-1413-xen_US
dc.identifier.issn2190-572Xen_US
dc.identifier.issn2190-5738en_US
dc.identifier.issue9en_US
dc.identifier.pmid30221108en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s13205-018-1413-x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36591
dc.identifier.volume8en_US
dc.identifier.wosWOS:000443529500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartof3 BIOTECHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntibacterial activityen_US
dc.subjectCytotoxicityen_US
dc.subjectHerbal medicineen_US
dc.subjectEssential oilsen_US
dc.subjectMedicinal plantsen_US
dc.subjectTraditional medicineen_US
dc.subjectEfflux pump inhibitoren_US
dc.titleEssential oils from tropical medicinal herbs and food plants inhibit biofilm formation in vitro and are non-cytotoxic to human cellsen_US
dc.typeArticleen_US

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