Influence of ketamine on the cardiopulmonary effects of intramuscular administration of dexmedetomidine-buprenorphine with subsequent reversal with atipamezole in dogs

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dc.contributor.authorKo, Jeff C.
dc.contributor.authorBarletta, Michele
dc.contributor.authorSen, Ismail
dc.contributor.authorWeil, Ann B.
dc.contributor.authorKrimins, Rebecca A.
dc.contributor.authorPayton, Mark E.
dc.contributor.authorConstable, Peter
dc.date.accessioned2020-03-26T18:42:11Z
dc.date.available2020-03-26T18:42:11Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective-To compare the cardiorespiratory effects of IM administration of dexmedetomidine-buprenorphine (DB) and dexmedetomidine-buprenorphine-ketamine (DBK) in dogs with subsequent reversal with atipamezole. Design-Prospective, randomized crossover study. Animals-5 healthy dogs. Procedures-Dogs were instrumented for cardiac output (CO) measurement and received DB (15 mu g of dexmedetomidine/kg [6.8 mu g/lb] and 40 mu g of buprenorphine/kg [18.2 mu g/lb]) or DBK (DB plus 3 mg of ketamine/kg [1.36 mg/lb]) in randomized order while breathing room air. Atipamezole (150 mu g/kg [68.2 mu g.lb], IM) was administered 1 hour later. Hemodynamic data were collected in the conscious dogs and then at 5, 10, 15, 20, 30, 45, and 60 minutes after drug administration. Lactate concentration was measured in mixed venous blood samples. Oxygen delivery (Do(2)) and oxygen consumption (center dot Vo(2)) were calculated. Results-Heart rate (HR), CO, and Do(2) decreased after DB and DBK administration. The Vo(2) did not change in the DB group but decreased in the DBK group. The HR was, higher in the DBK group than in the DB group throughout the study, but the CO, Do(2), and Vo(2) values were similar for the 2 groups. Blood lactate concentrations remained low (< 1 mmol/L) throughout the study. Arterial hypoxemia and hypercapnea occurred in both groups. Mean arterial blood pressure and pulmonary artery wedge pressure were markedly increased in both groups, but to a greater extent in the DBK group. After atipamezole administration, HR, CO, and Do(2) returned to the baseline values. Conclusions and Clinical Relevance-Adding ketamine to the DB combination allowed dogs to maintain a higher HR and delayed the onset of sinus arrhythmias but failed to provide a significantly higher CO because of a reduction in stroke volume. (J Am Vet Med Assoc 2013;242:339-345)en_US
dc.identifier.doi10.2460/javma.242.3.339en_US
dc.identifier.endpage345en_US
dc.identifier.issn0003-1488en_US
dc.identifier.issn1943-569Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid23327175en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://dx.doi.org/10.2460/javma.242.3.339
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29573
dc.identifier.volume242en_US
dc.identifier.wosWOS:000314558200009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER VETERINARY MEDICAL ASSOCen_US
dc.relation.ispartofJAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleInfluence of ketamine on the cardiopulmonary effects of intramuscular administration of dexmedetomidine-buprenorphine with subsequent reversal with atipamezole in dogsen_US
dc.typeArticleen_US

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