The relaxant effects of alfentanil and remifentanil on noradrenaline-treated rat aorta
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
VSP BV
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and objective: In this in vitro study on rat thoracic aorta, the effects of indomethacin (a prostaglandin synthesis inhibitor), propranolol (a beta adrenergic receptor blocker), tetraethylammonium (TEA) (a calcium-actived potassium channel blocker), glibenclamide (an ATP-dependent potassium channel blocker) and naloxone (an opioid receptor antagonist) on the responses induced by alfentanil and rernifentanil were investigated. Methods: Aortas isolated from rats were cut into spiral strips 12 mm in length, 3 mm wide. Strips were mounted in organ baths at 37degreesC continuously gassed with 95% and 5% CO2. The responses of the drugs were recorded isometrically on polygraph. Results: In both groups, strips were precontracted with 10(-6) M noradrenaline (NA). Then alfentanil or remifentanil (10(-8) to 10(-5) M) was administered cumulatively. Both alfentanil and rernifentanil significantly produced relaxation (p < 0.05). Indomethacin, propranolol, TEA, glibenclamide and naloxone did not significantly modify responses of the opioids. The rank order of potencies of these drugs was alfentanil > remifentanil. Conclusion: Prostaglandins, beta adrenergic receptors, potassium channels and opioid receptors have no role in the responses induced by alfentanil and remifentanil.
Açıklama
Anahtar Kelimeler
rat thoracic aorta, alfentanil, remifentanil
Kaynak
PAIN CLINIC
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
15
Sayı
3
