The relaxant effects of alfentanil and remifentanil on noradrenaline-treated rat aorta

Basit Öğe Kaydı
dc.contributor.authorTuncer, S
dc.contributor.authorBariskaner, H
dc.contributor.authorDogan, N
dc.date.accessioned2020-03-26T16:46:15Z
dc.date.available2020-03-26T16:46:15Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and objective: In this in vitro study on rat thoracic aorta, the effects of indomethacin (a prostaglandin synthesis inhibitor), propranolol (a beta adrenergic receptor blocker), tetraethylammonium (TEA) (a calcium-actived potassium channel blocker), glibenclamide (an ATP-dependent potassium channel blocker) and naloxone (an opioid receptor antagonist) on the responses induced by alfentanil and rernifentanil were investigated. Methods: Aortas isolated from rats were cut into spiral strips 12 mm in length, 3 mm wide. Strips were mounted in organ baths at 37degreesC continuously gassed with 95% and 5% CO2. The responses of the drugs were recorded isometrically on polygraph. Results: In both groups, strips were precontracted with 10(-6) M noradrenaline (NA). Then alfentanil or remifentanil (10(-8) to 10(-5) M) was administered cumulatively. Both alfentanil and rernifentanil significantly produced relaxation (p < 0.05). Indomethacin, propranolol, TEA, glibenclamide and naloxone did not significantly modify responses of the opioids. The rank order of potencies of these drugs was alfentanil > remifentanil. Conclusion: Prostaglandins, beta adrenergic receptors, potassium channels and opioid receptors have no role in the responses induced by alfentanil and remifentanil.en_US
dc.identifier.doi10.1163/156856903767650862en_US
dc.identifier.endpage325en_US
dc.identifier.issn0169-1112en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://dx.doi.org/10.1163/156856903767650862
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18605
dc.identifier.volume15en_US
dc.identifier.wosWOS:000185739800017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVSP BVen_US
dc.relation.ispartofPAIN CLINICen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectrat thoracic aortaen_US
dc.subjectalfentanilen_US
dc.subjectremifentanilen_US
dc.titleThe relaxant effects of alfentanil and remifentanil on noradrenaline-treated rat aortaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu