Effects of fish oil on cell proliferation and liver injury in an experimental model of acute hepatic injury induced by carbon tetrachloride

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dc.contributor.authorKorkmaz, H.
dc.contributor.authorTemel, T.
dc.contributor.authorBugdaci, M. S.
dc.contributor.authorTekelioglu, Y.
dc.contributor.authorOzoran, Y.
dc.contributor.authorKapicioglu, S.
dc.date.accessioned2020-03-26T18:50:21Z
dc.date.available2020-03-26T18:50:21Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate the effect of fish oil on the hepatic injury and cell cycle phases as well as cellular proliferation-regeneration in a rat model of acute hepatic injury induced by carbon tetrachloride. Background: Compensatory cell proliferation and tissue regeneration occurs as an endogenous response following chemical damage to the liver and enable animals to over come the injury. Data related to effect of fish oil on liver injury induced by chemical hepatotoxicants are controversial. Method: 60 male Wistar-albino rats were fed either with a diet supplemented with 20% fish oil or standard rat feed for 2 weeks. After an overnight fast, rats in each group were administered either 1 ml/kg carbon tetrachloride or saline intraperitoneally. Results: Fish oil enriched diet significantly enhanced the carbon tetrachloride - associated necroinflammatory damage, ballooning degeneration and the elevation of serum transaminases induced by carbon tetrachloride. Furthermore fish oil diet prevented cell proliferation, increased the proportion of cells in the G0/G1phase concomitant with a decrease in the proportion of cells in the S phase cells. Conclusion: Fish oil diet exacerbates the hepatic injury and prevents cell proliferation-regeneration in normal and injured liver cells. Suppression of tissue regeneration by fish oil may lead to progression of the hepatic injury (Tab. 3, Fig. 4, Ref. 31). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2014_039en_US
dc.identifier.endpage189en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issn1336-0345en_US
dc.identifier.issue4en_US
dc.identifier.pmid24797591en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://dx.doi.org/10.4149/BLL_2014_039
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30794
dc.identifier.volume115en_US
dc.identifier.wosWOS:000335542500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecthepatic injuryen_US
dc.subjectfish oilen_US
dc.subjectn-3 PUFAsen_US
dc.subjectcell-cycleen_US
dc.subjectcarbon tetrachlorideen_US
dc.titleEffects of fish oil on cell proliferation and liver injury in an experimental model of acute hepatic injury induced by carbon tetrachlorideen_US
dc.typeArticleen_US

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