Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues

Basit Öğe Kaydı
dc.contributor.authorOzturk, Bahadir
dc.contributor.authorKocaoglu, Ender Hilmi
dc.contributor.authorDurak, Zahide Esra
dc.date.accessioned2020-03-26T19:05:52Z
dc.date.available2020-03-26T19:05:52Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Investigation of possible effects of Silybum marianum extract (SME) on adenosine deaminase (ADA) activity in cancerous and noncancerous human gastric and colon tissues to obtain information about possible mechanism of anticancer action of S. marianum. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues removed from patients by surgical operations were used in the studies. The extract was prepared in distilled water. Before and after treatment with the extract, ADA activities in the samples were measured. Results: ADA activity was found to be lowered significantly in cancerous gastric tissues but not in noncancerous gastric tissues after treatment with the SME. In the colon tissues, ADA activities were however found to increase after the treatment of SME. Conclusion: Our results suggest that the aqueous extract from S. marianum inhibits ADA activity in cancerous gastric tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA might also play a part in the anticancer properties of the S. marianum.en_US
dc.identifier.doi10.4103/0973-1296.149729en_US
dc.identifier.endpage146en_US
dc.identifier.issn0973-1296en_US
dc.identifier.issn0976-4062en_US
dc.identifier.issue41en_US
dc.identifier.pmid25709224en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://dx.doi.org/10.4103/0973-1296.149729
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32062
dc.identifier.volume11en_US
dc.identifier.wosWOS:000348610800022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofPHARMACOGNOSY MAGAZINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdenosine deaminaseen_US
dc.subjectcanceren_US
dc.subjectcolon tissueen_US
dc.subjectgastric tissueen_US
dc.subjectSilybum marianumen_US
dc.titleEffects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissuesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu