Oxidative imbalance in adult attention deficit/hyperactivity disorder

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dc.contributor.authorSelek, Salih
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorGergerlioglu, H. Serdar
dc.contributor.authorBulut, Mahmut
dc.contributor.authorYilmaz, H. Ramazan
dc.date.accessioned2020-03-26T17:27:24Z
dc.date.available2020-03-26T17:27:24Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: There are few studies evaluating the biochemical basis of adult attention deficit/hyperactivity disorder (A-ADHD). In the present study, we evaluated whether nitric oxide (NO), an oxidant, level and superoxide dismutase (SOD), an antioxidant, activity are associated with A-ADHD or not. Methods: Twenty A-ADHD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinic, diagnosed according to The Turkish version of Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale by two psychiatrists (H.A.S. and S.S.), and twenty-one healthy volunteer controls were included. Blood samples were collected; NO levels and SOD activities were measured. Results: The mean NO levels in patients were significantly higher than those of controls and SOD activity of patients was significantly lower than controls. Conclusions: Remarkable high levels of oxidant NO, and low SOD activities suggest an oxidative imbalance in A-ADHD. This is the first study evaluating the oxidative metabolism in A-ADHD. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.biopsycho.2008.06.005en_US
dc.identifier.endpage259en_US
dc.identifier.issn0301-0511en_US
dc.identifier.issue2en_US
dc.identifier.pmid18644422en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopsycho.2008.06.005
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22553
dc.identifier.volume79en_US
dc.identifier.wosWOS:000260283400017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofBIOLOGICAL PSYCHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdult attention deficit hyperactivity disorderen_US
dc.subjectNitric oxideen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectOxidative stressen_US
dc.titleOxidative imbalance in adult attention deficit/hyperactivity disorderen_US
dc.typeArticleen_US

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