Pre- and post-estrogen administration in global cerebral ischemia reduces blood-brain barrier breakdown in ovariectomized rats

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dc.contributor.authorUzum, G.
dc.contributor.authorBahcekapili, N.
dc.contributor.authorBaltacı, A. K.
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorZiylan, Yusuf Ziya
dc.date.accessioned2020-03-26T19:06:42Z
dc.date.available2020-03-26T19:06:42Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of present study was to determine the effect of estrogen treatment on blood-brain barrier permeability in rats with induced global cerebral ischemia. The study included six-month-old female Sprague-Dawley rats which were divided into the following groups: Control-Ischemia-Reperfusion (C + I-R); Ovariectomy-Ischemia-Reperfusion (Ovx + I-R); Ovariectomy + Estrogen + Ischemia-Reperfusion (Ovx + E + I-R); Ovariectomy + Ischemia-Reperfusion + Estrogen (Ovx + I-R + E). Ischemia-reperfusion was induced by clamping two carotid arteries, then opening the clamp. Blood-brain barrier permeability was visualized by Evans Blue extravasation and quantified by spectrophotometry. Our results indicate that following ischemia-reperfusion the BBB permeability is increased in ovariectomized rats (Evans Blue extravasation) compared to the control group in the cortex, thalamus, hippocampus, cerebellum and brain stem, while in the midbrain no significant increase was detected. In contrast, BBB permeability in the groups treated with estrogen, administered either before or after ischemia-reperfusion, was significantly lower than in ovariectomized animals. In conclusion, the increase in BBB permeability resulting from experimentally induced cerebral ischemia was prevented by exogenous estrogen treatment. The study results indicate that estrogen may be used for therapeutic purposes in ischemia-reperfusion.en_US
dc.identifier.doi10.1556/APhysiol.102.2015.1.6en_US
dc.identifier.endpage66en_US
dc.identifier.issn0231-424Xen_US
dc.identifier.issn1588-2683en_US
dc.identifier.issue1en_US
dc.identifier.pmid25804390en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage60en_US
dc.identifier.urihttps://dx.doi.org/10.1556/APhysiol.102.2015.1.6
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32444
dc.identifier.volume102en_US
dc.identifier.wosWOS:000351869500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO RTen_US
dc.relation.ispartofACTA PHYSIOLOGICA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectblood-brain barrier (BBB)en_US
dc.subjectovariectomyen_US
dc.subjectestrogen treatmenten_US
dc.subjectEvans Blueen_US
dc.subjectraten_US
dc.titlePre- and post-estrogen administration in global cerebral ischemia reduces blood-brain barrier breakdown in ovariectomized ratsen_US
dc.typeArticleen_US

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