Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Beh double dagger et's disease with or without ocular involvement

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dc.contributor.authorDursun, Ahmet
dc.contributor.authorDurakbasi-Dursun, Hatice Gul
dc.contributor.authorDursun, Recep
dc.contributor.authorBaris, Savas
dc.contributor.authorAkduman, Levent
dc.date.accessioned2020-03-26T17:37:52Z
dc.date.available2020-03-26T17:37:52Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe association of known ACE gene and eNOS gene polymorphisms with BD in a group of Turkish patients with or without ocular involvement has been investigated. The ACE and eNOS gene polymorphisms were investigated in 73 BD patients and 90 controls. The distrubition of "DD", "ID" and "II" genotypes of the ACE gene were 32 (43.8%), 29 (39.8%) and 12 (16.4%) for BD patients and 32 (35.5%), 35 (38.9%) and 23 (25.6%) for healthy controls. There was no significant difference between the groups (p = 0.140, OR 1.44, CI 0.90-2.30). When Beh double dagger et patients with ocular involvement were compared to the control group, statistical significance was found (p = 0.049, OR 2.18, CI 1.00-4.81). The "bb", "ba", and "aa" genotype frequencies of the eNOS gene were 48 (65.8%), 23 (31.5%), and 2 (2.7%) for patients with BD and 75 (83.3%), 15 (16.7%), and 0 (0%) for healthy controls, respectively. The significant difference found in allelic frequencies between the two groups (p = 0.011, OR 2.32, CI 1.11-4.87). When Beh double dagger et patients with ocular involvement were compared, sharper statistical significance was found (p = 0.001,OR 4.61,CI 1.85-11.52). The ACE gene polymorphism does not play a role in the pathogenesis of BD. The findings of the eNOS gene polymorphisms confirmed the significant association with BD and even more in patients with ocular involvement.en_US
dc.identifier.doi10.1007/s00011-009-0005-yen_US
dc.identifier.endpage405en_US
dc.identifier.issn1023-3830en_US
dc.identifier.issn1420-908Xen_US
dc.identifier.issue7en_US
dc.identifier.pmid19255721en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00011-009-0005-y
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23281
dc.identifier.volume58en_US
dc.identifier.wosWOS:000267826500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER BASEL AGen_US
dc.relation.ispartofINFLAMMATION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectACE geneen_US
dc.subjecteNOS geneen_US
dc.subjectPolymorphismen_US
dc.subjectBehcet's diseaseen_US
dc.subjectUveitisen_US
dc.titleAngiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Beh double dagger et's disease with or without ocular involvementen_US
dc.typeArticleen_US

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