Effects of Prednisolone, l-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas
dc.contributor.author | Kose, Dogan | |
dc.contributor.author | Tarakci, Nuriye | |
dc.contributor.author | Celik, Zeliha Esin | |
dc.contributor.author | Vatansev, Husamettin | |
dc.contributor.author | Cimbek, Emine Ayca | |
dc.contributor.author | Ugras, Serdar | |
dc.contributor.author | Sen, Yasar | |
dc.date.accessioned | 2020-03-26T19:23:51Z | |
dc.date.available | 2020-03-26T19:23:51Z | |
dc.date.issued | 2016 | |
dc.department | Selçuk Üniversitesi | en_US |
dc.description.abstract | The aim of this study is to determine the effects of l-asparaginase (l-ASP), corticosteroids (CSs), and antilipidemics, separately and in combination, on the lipid profiles and the liver and pancreas histology in mice. This study included 8 groups of 7 mice each. Before any drug administration, serum samples were taken from all of the mice. Then, normal saline was applied to the control group, and a medication or combination of medications was applied to the other groups. Levels of triglycerides, cholesterol (COL), and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined, and the livers and pancreases were evaluated histologically at the end of the study. Triglycerides increased significantly in the CS-only and the l-ASP-only groups, COL increased significantly in the CS-only group, and HDL increased significantly in the CS-only and the antilipidemic-only groups. LDL was significantly lower in the CS-only and the l-ASP-only groups. CSs and l-ASP were significantly effective in liver necrosis, l-ASP was significantly effective in liver balloon degeneration, and CS were significantly effective in pancreas vacuolization. Triglyceride measurement is recommended before/during CS and/or l-ASP treatment. Starting with an antilipidemic agent can be considered to avoid possible complications in patients with significantly high rates. Indicators of a possible liver or pancreas injury should also be considered. | en_US |
dc.description.sponsorship | Selcuk UniversitySelcuk University | en_US |
dc.description.sponsorship | Supported by Selcuk University. | en_US |
dc.identifier.doi | 10.1097/MPH.0000000000000484 | en_US |
dc.identifier.endpage | E49 | en_US |
dc.identifier.issn | 1077-4114 | en_US |
dc.identifier.issn | 1536-3678 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 26599986 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | E42 | en_US |
dc.identifier.uri | https://dx.doi.org/10.1097/MPH.0000000000000484 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12395/33514 | |
dc.identifier.volume | 38 | en_US |
dc.identifier.wos | WOS:000372838700012 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.ispartof | JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.selcuk | 20240510_oaig | en_US |
dc.subject | prednisolone | en_US |
dc.subject | lipid | en_US |
dc.subject | asparaginase | en_US |
dc.subject | gemfibrozil | en_US |
dc.title | Effects of Prednisolone, l-Asparaginase, Gemfibrozil, and Combinations of These Elements on Mice Lipid Profile, Liver, and Pancreas | en_US |
dc.type | Article | en_US |