The effect of midkine on growth factors and oxidative status in an experimental wound model in diabetic and healthy rats

Basit Öğe Kaydı
dc.contributor.authorDik, Burak
dc.contributor.authorBas, Ahmet Levent
dc.contributor.authorYazihan, Nuray
dc.date.accessioned2020-03-26T19:42:53Z
dc.date.available2020-03-26T19:42:53Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWound healing is important for longevity. Midkine is a cytokine involved in controlling tissue repair and new tissue development, and in regulating inflammation. We investigated the effect of midkine on wound healing in rats. In total, 108 Wistar albino rats were used: 12 as healthy and diabetic controls; 96 were split into 4 groups: healthy, saline treated; healthy, midkine (10 ng/kg, 48 h intervals) treated; diabetic, saline treated; and diabetic, midkine treated. Following wound creation, 6 rats per group were euthanized on days 3, 7, 14, and 28; the wounded skin was removed. Levels of epidermal growth factor (EGF), matrix metalloproteinase-8 (MMP-8), transforming growth factor beta (TGF-beta), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and thiobarbituric acid reactive substances (TBARS) were measured. MMP-8 and PDGF levels fluctuated in all groups; TGF-beta fluctuated in the diabetic groups and was significantly higher in the HM group than other groups after 14 days. EGF and VEGF levels were increased in the HM group after 3 days. TBARS levels were highest in the diabetic groups. Macroscopically, the midkine-treated groups healed better. Midkine can accelerate wound healing by influencing growth factors and oxidative status in wound tissues.en_US
dc.description.sponsorshipSUPABK [12102003]; BSTB [0443. Stz 2013-2]en_US
dc.description.sponsorshipThis article was summarized from the Ph.D. thesis of the first named author. This study is supported by SUPABK (12102003) and BSTB (0443. Stz 2013-2). A part of the abstract was presented as a poster at the 5th International Congress on Cell Membranes and Oxidative Stress Congress, Isparta, Turkey, and the abstract was printed in the book of proceedings. We thank Enver Yazar for scientific assistance.en_US
dc.identifier.doi10.1139/cjpp-2016-0439en_US
dc.identifier.endpage609en_US
dc.identifier.issn0008-4212en_US
dc.identifier.issn1205-7541en_US
dc.identifier.issue5en_US
dc.identifier.pmid28177680en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage604en_US
dc.identifier.urihttps://dx.doi.org/10.1139/cjpp-2016-0439
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35547
dc.identifier.volume95en_US
dc.identifier.wosWOS:000400068100016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCANADIAN SCIENCE PUBLISHINGen_US
dc.relation.ispartofCANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmidkineen_US
dc.subjectwound healingen_US
dc.subjectgrowth factorsen_US
dc.titleThe effect of midkine on growth factors and oxidative status in an experimental wound model in diabetic and healthy ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu