Superoxide dismutase and glutathione peroxidase enzyme activities in larynx carcinoma

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dc.contributor.authorKalayci, A
dc.contributor.authorOzturk, A
dc.contributor.authorOzturk, K
dc.contributor.authorKaragozoglu, E
dc.contributor.authorDolanmaz, D
dc.date.accessioned2020-03-26T16:58:03Z
dc.date.available2020-03-26T16:58:03Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractConclusions. It can be concluded that these changes are related to damage at the DNA level or to the inhibitory effects of tumor promoters. Increases in GSH-Px activities may be related to the independence of this enzyme from the suppressive effects of tumor promoters. This study and others in the literature show that it is not possible to generalize the activities of SOD and GSH-Px in cancer. Objective. There has been growing interest in the role of free radicals as a cause of cancer. It has been suggested that an increase in activated forms of oxygen in cells due to overproduction and/or the inability to destroy them may lead to severe damage of cell structures. As a result of these changes, some chromosomal aberrations and carcinogenesis may develop. Superoxide dismutase ( SOD) and glutathione peroxidase (GSH-Px) are two important antioxidant enzymes involved in enzymatic antioxidant defense mechanisms. To our knowledge there have been no previous studies in the literature investigating the activities of SOD and GSH-Px in laryngeal cancer. Material and methods. The study subjects comprised 10 male patients (age range 43-76 years) with laryngeal carcinoma and 10 healthy controls ( 4 males, 6 females; age range 40-69 years) with intraoral hyperplastic fibrous tissue. Homogenate SOD and GSH-Px activities were measured using commercially available kits. Results. GSH-Px levels were significantly increased in the cancerous tissues compared with cancer-free adjacent tissues and fibrous hyperplasia tissues (p < 0.05), whereas there was no significant difference between SOD activities (p > 0.05). There was also no significant difference between GSH-Px activity in cancer-free adjacent tissues and fibrous hyperplasia tissues (p > 0.05).en_US
dc.identifier.doi10.1080/00016480410023074en_US
dc.identifier.endpage315en_US
dc.identifier.issn0001-6489en_US
dc.identifier.issue3en_US
dc.identifier.pmid15966704en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage312en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00016480410023074
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19893
dc.identifier.volume125en_US
dc.identifier.wosWOS:000227427200016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS ASen_US
dc.relation.ispartofACTA OTO-LARYNGOLOGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcanceren_US
dc.subjectenzymeen_US
dc.subjectfibrous hyperplasiaen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectlarynxen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjecttissueen_US
dc.titleSuperoxide dismutase and glutathione peroxidase enzyme activities in larynx carcinomaen_US
dc.typeArticleen_US

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