Circulating leptin, zinc, and copper levels after extracorporeal circulation

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dc.contributor.authorGormus, ZI
dc.contributor.authorGormus, N
dc.contributor.authorBaltaci, AK
dc.contributor.authorHalifeoglu, I
dc.contributor.authorMogulkoc, R
dc.date.accessioned2020-03-26T16:56:41Z
dc.date.available2020-03-26T16:56:41Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: The role of leptin in the acute stress response to extracorporeal circulation has been well documented, however, the relationship between leptin and zinc has not been investigated previously. We aimed to research the circulating leptin, zinc, and copper levels before, during, and after the extracorporeal circulation, and effect of preoperative zinc administration to these. METHODS: Twenty patients who were taken to elective coronary artery bypass grafting operations using extracorporeal circulation were taken to this research and divided into two equal groups (n(1), n(2)). In both groups blood samples were taken just before the operation (T0), at the end of operation (T1), and at the first postoperative day (T2). In the second group (n(2)) oral zinc (50 mg, once a day) was administered to patients for 5 days, preoperatively. The serum leptin, zinc, and copper levels were studied. RESULTS: In group n(1) circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p < 0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p < 0.05); copper levels were decreased at T2 when compared to T0 (p < 0.05), and decreased at T1 when compared to T0 (p < 0.05). In group n(2) circulating leptin levels were significantly increased at T2 when compared to T0 and T1 (p < 0.05); zinc levels were decreased at T2 when compared to T0 and T1 (p < 0.05); copper levels were increased at T2 when compared to T1 (p < 0.05). CONCLUSIONS: These results indicate that circulating leptin levels increase after the extracorporeal circulation as an acute response, while zinc and copper levels decrease at the same period. Preoperative zinc administration does not prevent the leptin response after extracorporeal circulation.en_US
dc.identifier.endpage842en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid16380701en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage839en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19626
dc.identifier.volume26en_US
dc.identifier.wosWOS:000236048900043en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMAGHIRA & MAAS PUBLICATIONSen_US
dc.relation.ispartofNEUROENDOCRINOLOGY LETTERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectextracorporeal circulationen_US
dc.subjectleptinen_US
dc.subjectzincen_US
dc.subjectcopperen_US
dc.titleCirculating leptin, zinc, and copper levels after extracorporeal circulationen_US
dc.typeArticleen_US

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