The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury

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dc.contributor.authorCosar, Emine
dc.contributor.authorSahin, Figen Kir
dc.contributor.authorKoken, Guelenguel
dc.contributor.authorToy, Hatice
dc.contributor.authorBasarali, Kemal
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2020-03-26T17:18:36Z
dc.date.available2020-03-26T17:18:36Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe investigated the effect of alpha-lipoic acid (LA) on reperfusion injury in a rat ovarian torsion-detorsion model. The changes in tissue and plasma levels of malondialdehyde (MDA), end-product of lipid peroxidation, superoxide dismutase (SOD), xanthine oxidase (XO) and nitric oxide (NO), were determined. Ovarian histopathological findings were scored and compared among groups. Thirty-two female Sprague-Dawley rats were divided into four groups. Sham operation was performed in group I; in group II only ovarian torsion was performed. Group III received intraperitoneal injections of saline, and group IV received LA via intraperitoneal injections (LA group: aqueous solution at 36 mg/kg of body weight per day, saline group: equal volume of saline) 21, nine, and one hour before torsion of the ovary. Rats in the torsion group were killed after 360 degrees clockwise adnexial torsion for three hours, and ovaries were harvested. After three hours of adnexial detorsion, the rats in saline group and LA group were killed and adnexa were surgically removed. Ovarian tissue damage scores were significantly different among groups and were seen to correlate with tissue MDA levels. Ovarian tissue and serum MDA, NO and serum XO levels in the group III were significantly higher than those of the groups I and IV (P < 0.05). The serum levels of SOD in the group III were significantly lower than those of the groups I and IV (P < 0.05). These results suggest that LA pretreatment has beneficial effects in the prevention of ischaemia-reperfusion injury of the ovaries.en_US
dc.identifier.doi10.1111/j.1479-828X.2007.00787.xen_US
dc.identifier.endpage503en_US
dc.identifier.issn0004-8666en_US
dc.identifier.issue6en_US
dc.identifier.pmid17991117en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1479-828X.2007.00787.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21697
dc.identifier.volume47en_US
dc.identifier.wosWOS:000250760800014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofAUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadnexial torsionen_US
dc.subjectalpha-lipoic aciden_US
dc.subjectischaemia-reperfusionen_US
dc.subjectmalondialdehyde (MDA)en_US
dc.subjectsuperoxide (SOD)en_US
dc.subjectxanthine oxidase (XO)en_US
dc.titleThe protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injuryen_US
dc.typeArticleen_US

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