Is the Mean Platelet Volume a Predictive Marker of a Low Apgar Score and Insulin Resistance in Gestational Diabetes Mellitus? A Retrospective Case-Control Study

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dc.contributor.authorKebapcilar, Levent
dc.contributor.authorKebapcilar, Ayse Gul
dc.contributor.authorIlhan, Tolgay Tuyan
dc.contributor.authorIpekci, Suleyman Hilmi
dc.contributor.authorBaldane, Suleyman
dc.contributor.authorPekin, Aybike
dc.contributor.authorKulaksizoglu, Mustafa
dc.date.accessioned2020-03-26T19:24:53Z
dc.date.available2020-03-26T19:24:53Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Gestational diabetes is defined as various degrees of glucose intolerance diagnosed or detected for the first time during pregnancy and is the most common metabolic complication of pregnancy. Early diagnosis and adequate treatment are important to prevent complications. Preeclampsia, polyhydramnios, fetalmacrosomia, and operative delivery are some of the complications seen in pregnant women diagnosed with Gestational Diabetes Mellitus (GDM). Aim: The present study was designed to determine whether there was an association between Mean Platelet Volume (MPV) in predicting poor fetal outcome, insulin resistance, neonatal Apgar scores and gestational age for women with GDM. Materials and Methods: In this retrospective study, we enrolled 101 pregnant women with GDM together with a group of 138 healthy controls. MPV, insulin and homeostatic model assessment (HOMA-IR) values were measured at 24-28 weeks of the pregnancy. An independent samples t-test was used to compare MPV values. Multivariate linear regression models were used to establish relations between MPV values, HOMAIR, insulin levels and Apgar score. Results: There was a significant positive correlation between MPV values, HOMA-IR and Insulin levels and a negative correlation with Apgar score at 1 min and 5 min in the GDM group (r=0.227, p=0.02; r=0.206, p=0.03; r=-0.485, p<0.001; and r=-0.399, p<0.001, respectively). In the multivariate logistic regression analysis, a high MPV value was most consistently associated with a low Apgar 1 min score (beta=-0.387, p=0.003) in the GDM group. An MPV of >8.0 fL had a sensitivity of 82% and a specificity of 75% for the prediction of GDM. Conclusion: We investigated the potential of MPV values in predicting low Apgar scores and insulin resistance in women with GDM.en_US
dc.identifier.doi10.7860/JCDR/2016/20874.8611en_US
dc.identifier.endpageOC10en_US
dc.identifier.issn2249-782Xen_US
dc.identifier.issn0973-709Xen_US
dc.identifier.issue10en_US
dc.identifier.pmid27891368en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpageOC6en_US
dc.identifier.urihttps://dx.doi.org/10.7860/JCDR/2016/20874.8611
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33744
dc.identifier.volume10en_US
dc.identifier.wosWOS:000397981700073en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPREMCHAND SHANTIDEVI RESEARCH FOUNDATIONen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGlucose intoleranceen_US
dc.subjectHOMA-IR indexen_US
dc.subjectHyperglycaemiaen_US
dc.subjectMetabolic complicationen_US
dc.subjectPregnancyen_US
dc.titleIs the Mean Platelet Volume a Predictive Marker of a Low Apgar Score and Insulin Resistance in Gestational Diabetes Mellitus? A Retrospective Case-Control Studyen_US
dc.typeArticleen_US

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