ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS

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dc.contributor.authorEr, Ayse
dc.contributor.authorAltan, Feray
dc.contributor.authorCetin, Gul
dc.contributor.authorDik, Burak
dc.contributor.authorElmas, Muammer
dc.contributor.authorYazar, Enver
dc.date.accessioned2020-03-26T18:13:49Z
dc.date.available2020-03-26T18:13:49Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gammaglutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, beta-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.en_US
dc.identifier.doi10.1556/AVet.2011.015en_US
dc.identifier.endpage335en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issn1588-2705en_US
dc.identifier.issue3en_US
dc.identifier.pmid21727065en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.2011.015
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26170
dc.identifier.volume59en_US
dc.identifier.wosWOS:000292467600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADO ZRTen_US
dc.relation.ispartofACTA VETERINARIA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTulathromycinen_US
dc.subjectcardiotoxicityen_US
dc.titleASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITSen_US
dc.typeArticleen_US

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