Effect of pentoxifylline and 5-fluorouracil/triamcinolone on laryngotracheal stenosis developing as a complication of tracheostomy: study in rats

Basit Öğe Kaydı
dc.contributor.authorKoc, Sema
dc.contributor.authorKiyici, Halil
dc.contributor.authorSogut, Erkan
dc.contributor.authorEyibilen, Ahmet
dc.contributor.authorEkici, Adnan
dc.contributor.authorSalman, Nergis
dc.date.accessioned2020-03-26T18:25:03Z
dc.date.available2020-03-26T18:25:03Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe aimed to investigate the prophylactic effect of pentoxifylline (PTX) and 5-fluorouracil (5-FU) on laryngotracheal stenosis in tracheotomised rats by evaluating blood glutathione peroxidase (GPx) and superoxide dismutase activities and by histopathological evaluation of laryngotracheal segment. Randomized prospective single-blind study. Standard vertical tracheotomy was performed on 24 rats. Then, the animals were randomly divided into three groups. Intraperitoneal PTX administered to group A (study group) for 10 days. 5-FU was injected in paratracheal tissues in group B (study group) for 10 days. In group C (control group), intraperitoneal saline was administered for 10 days. After 10 days, tracheal cannules were removed. For biochemical analysis, two blood samples were obtained. Three weeks later, all animals were euthanized and trachea specimens were harvested. Stenosis index and mean wall thickness in PTX group were lower as compared to other groups but the difference was statistically insignificant. Minimum inflammation and fibrosis plus maximum epithelial regeneration were seen in PTX group. In addition, GPx activity was at highest level in PTX group and a statistically significant difference was found between control and PTX groups (P = 0.024) though the difference between remaining groups was statistically insignificant (P = 0.121). Superoxide dismutase activity was highest in PTX group but no statistically significant difference was found between the three groups (P = 0.305). The administration of PTX increases GPx activity and it may have some effect on tracheal scar formation which develops following tracheostomy.en_US
dc.identifier.doi10.1007/s00405-012-1936-4en_US
dc.identifier.endpage1820en_US
dc.identifier.issn0937-4477en_US
dc.identifier.issue7en_US
dc.identifier.pmid22327488en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1813en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-012-1936-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27949
dc.identifier.volume269en_US
dc.identifier.wosWOS:000304700600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTracheostomyen_US
dc.subjectLaryngotracheal stenosisen_US
dc.subjectPentoxifyllineen_US
dc.subject5-fluorouracilen_US
dc.titleEffect of pentoxifylline and 5-fluorouracil/triamcinolone on laryngotracheal stenosis developing as a complication of tracheostomy: study in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu