The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats

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dc.contributor.authorAtıcı, Emine
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltacı, Abdülkerim Kasım
dc.contributor.authorMenevşe, Esma
dc.date.accessioned2020-03-26T19:42:55Z
dc.date.available2020-03-26T19:42:55Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim: The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods: The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks' thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks' thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels. Results: It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001). Conclusion: The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.en_US
dc.description.sponsorshipSelcuk University, Scientific Research CouncilSelcuk University [14202034]en_US
dc.description.sponsorshipThis study was supported by a grant Selcuk University, Scientific Research Council (Grant number is 14202034).en_US
dc.identifier.doi10.1515/hmbci-2017-0033en_US
dc.identifier.issn1868-1883en_US
dc.identifier.issn1868-1891en_US
dc.identifier.issue3en_US
dc.identifier.pmid28796641en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1515/hmbci-2017-0033
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35556
dc.identifier.volume32en_US
dc.identifier.wosWOS:000419280300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofHORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadiponectinen_US
dc.subjectnesfatin-1en_US
dc.subjectraten_US
dc.subjectthyroid dysfunctionen_US
dc.titleThe effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in ratsen_US
dc.typeArticleen_US

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