Adding Ketoprofen to Intravenous Patient-Controlled Analgesia With Tramadol After Major Gynecological Cancer Surgery: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial

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dc.contributor.authorTuncer, Sema
dc.contributor.authorPirbudak, Lütfiye
dc.contributor.authorBalat, Özcan
dc.contributor.authorCapar, M.
dc.date.accessioned2020-03-26T16:45:24Z
dc.date.available2020-03-26T16:45:24Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractKetoprofen is a NSAIDs of the 2-aryl propionic acid class commonly used in the treatment of inflammatory rheumatic disease, acute pain and fever. Clinically, ketoprofen seems to reduce morphine requirements by 33 to 40% with ketoprofen's supposed central mechanism of analgesia. We evaluated the efficacy and safety of intravenous (IV) ketoprofen as an adjuvant to IV PCA (patient con- trolled analgesia) with tramadol after major gynecological cancer surgery for postoperative analgesia. Fifty patients were enrolled in this double-blinded, randomized, placebo-controlled study. Patients were allocated randomly to two groups: group I (25 patients) served as a control group, with patients receiving saline; group II (25 patients) received ketopro- fen. Patients received an intravenous bolus of saline or 100 mg ketoprofen at the end of surgery. Then, PCA was given as a 20 mg tramadol bolus and 10 min lockout time. Pain relief was regularly assessed using a visual analog scale. Tramadol consumption, side effects, and patient satisfaction were noted during the 24 hours after the surgery. No significant difference was observed in pain score, side-effects and patient satisfaction between the groups (p > 0.05). The cumulative PCA-tramadol consumption was lower in the ketoprofen-treated patients than placebo-treated patients (p < 0.05). Our results demonstrate that a single dose of 100 mg ketoprofen reduced tramadol consumption for treatment of postoperative pain after major gynecological cancer surgery.en_US
dc.identifier.citationTuncer, S., Pirbudak, L., Balat, Ö., Capar, M., (2003). Adding Ketoprofen to Intravenous Patient-Controlled Analgesia With Tramadol After Major Gynecological Cancer Surgery: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial. European Journal of Gynaecological Oncology, 24(2), 181-184.
dc.identifier.endpage184en_US
dc.identifier.issn0392-2936en_US
dc.identifier.issue2en_US
dc.identifier.pmid12701975en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18361
dc.identifier.volume24en_US
dc.identifier.wosWOS:000182102800020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuncer, Sema
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectketoprofenen_US
dc.subjecttramadolen_US
dc.subjectpostoperative painen_US
dc.subjectPCAen_US
dc.subjectmajor gynecological surgeryen_US
dc.titleAdding Ketoprofen to Intravenous Patient-Controlled Analgesia With Tramadol After Major Gynecological Cancer Surgery: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trialen_US
dc.typeArticleen_US

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