Encapsulation of enrofloxacin in liposomes I: Preparation and in vitro characterization of LUV

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dc.contributor.authorSezer, Ali Demir
dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorAkbuğa, Julide
dc.date.accessioned2020-03-26T16:48:35Z
dc.date.available2020-03-26T16:48:35Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractLiposomes are effectively used in the treatment of microbial infections. Higher cellular uptake has been reported when antibiotics are encapsulated in liposomes. In this study, enrofloxacin (ENF) was encapsulated in large unilamellar vesicles (LUVs) and the effects of formulation variables on the liposome characteristics were investigated. Liposomes were prepared using dry lipid film method. A number of variables such as molar ratios of phospholipid (DPPC; DL-alpha-phosphatidylcholine dipalmitoyl), cholesterol, ENF and amount of alpha-tocopherol and the volumes of internal (chloroform) and external phases [phosphate buffered saline PBS (pH 7.4)] were studied. In vitro characterization of the liposomes including the encapsulation capacity, size and drug release properties were carried out. Using of this method, spherical LUV liposomes with high drug content could be produced. Particle size of liposomes changed between 3.12 and 4.95 mum. The molar ratios of DPPC, cholesterol and ENF affected the size of the liposome (p < 0.05). The drug encapsulation capacities were high and changed between 37.1% and 79.5%. The highest ENF encapsulation was obtained with the highest cholesterol content. An increase in the drug encapsulation capacity of the liposome was found with increasing molar ratios of DPPC, cholesterol and ENF (p < 0.05). Furthermore, the release of ENF from the liposomes decreased as the molar ratios of DPPC, cholesterol and ENF increased (p < 0.05). In conclusion, a convenient colloidal carrier for the controlled release of ENF can be prepared by changing the formulation parameters of LUVs.en_US
dc.identifier.doi10.1081/LPR-120039717en_US
dc.identifier.endpage86en_US
dc.identifier.issn0898-2104en_US
dc.identifier.issue01.02.2020en_US
dc.identifier.pmid15461934en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://dx.doi.org/10.1081/LPR-120039717
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19055
dc.identifier.volume14en_US
dc.identifier.wosWOS:000223984700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofJOURNAL OF LIPOSOME RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectenrofloxacinen_US
dc.subjectliposomeen_US
dc.subjectLUVen_US
dc.subjectcontrolled releaseen_US
dc.subjectdrug encapsulationen_US
dc.subjectstabilityen_US
dc.subjectformulationen_US
dc.titleEncapsulation of enrofloxacin in liposomes I: Preparation and in vitro characterization of LUVen_US
dc.typeArticleen_US

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