Determination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technology

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dc.contributor.authorTopcu-Yilmaz, Pinar
dc.contributor.authorAtakan, Nilgun
dc.contributor.authorBozkurt, Banu
dc.contributor.authorIrkec, Murat
dc.contributor.authorAban, Demet
dc.contributor.authorMesci, Lutfiye
dc.contributor.authorTezcan, Ilhan
dc.date.accessioned2020-03-26T18:41:29Z
dc.date.available2020-03-26T18:41:29Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To compare serum and tear inflammatory and anti-inflammatory cytokine levels of rosacea patients with the healthy controls and evaluate the correlation of tear cytokine levels with tear function parameters. Methods: Tear and serum interleukin (IL)-1 alpha, IL-6, IL-8, IL-10, monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP-1 alpha), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) levels were measured using multiplex bead (Luminex) technology in 12 rosacea patients without ocular involvement (group 1), 20 rosacea patients with ocular involvement (group 2), and 22 healthy subjects (group 3). The correlation of the cytokines with tear function parameters was analyzed using Spearman correlation test. Results: Tear IL-10 and VEGF levels were significantly lower in group 1 (median: 35.78 pg/mL and 427.29, respectively) and group 2 (median: 26.25 pg/mL and 348.31, respectively) than in group 3 (median: 75.96 pg/mL and 480.12, respectively) (p<0.05). Mean serum IL-8 level was significantly lower in group 2 (median = 0) compared to group 3 (median = 3.98) (p = 0.02). Tear breakup time was found to be positively correlated with IL-10 (r = 0.46, p = 0.013) and inversely correlated with MCP-1 (r = -0.52, p = 0.004). Conclusions: Tear and serum levels of cytokines and growth factors measured with Luminex technology showed a large variation in rosacea and healthy subjects. Decreased levels of tear IL-10, an anti-inflammatory cytokine, may lead to an inflammatory ocular surface environment, exacerbate ocular surface inflammation, and deteriorate tear function tests. A bigger sample size, including rosacea patients with corneal involvement, is needed to confirm the role of cytokines in the pathogenesis of rosacea-associated ocular inflammation.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107S312 (SBAG-HD-259)]en_US
dc.description.sponsorshipThis project was supported by grants from TUBITAK (The Scientific and Technological Research Council of Turkey) - 107S312 (SBAG-HD-259).en_US
dc.identifier.doi10.3109/09273948.2013.795229en_US
dc.identifier.endpage359en_US
dc.identifier.issn0927-3948en_US
dc.identifier.issn1744-5078en_US
dc.identifier.issue5en_US
dc.identifier.pmid23730902en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09273948.2013.795229
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29371
dc.identifier.volume21en_US
dc.identifier.wosWOS:000324403300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofOCULAR IMMUNOLOGY AND INFLAMMATIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokineen_US
dc.subjectinterleukinen_US
dc.subjectLuminex technologyen_US
dc.subjectrosaceaen_US
dc.titleDetermination of Tear and Serum Inflammatory Cytokines in Patients with Rosacea Using Multiplex Bead Technologyen_US
dc.typeArticleen_US

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